Mind your rhythms: an important role for circadian genes in neuroprotection
Open accessAbstract
Circadian rhythms govern nearly every physiological process in our brains and bodies. At the most basic level, the molecular clockwork in each cell interacts with metabolic cycles to influence the redox state, allowing for increased cellular activity at specific times of day. In this issue of the JCI, Musiek et al. show that genetic disruptions in the positive arm of the molecular clock can lead to severe astrogliosis, which likely occurs through disruptions in output genes that keep oxidative stress in check. This study demonstrates the importance of proper circadian protein function in the maintenance of neuronal integrity.
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- Authors
- McClung, C. A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- McClung, Colleen A.
- ORCID
- McClung, Colleen A.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-11-25
- Volume
- 123
- Issue
- 12
- Pages
- 4994-4996
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3859426
- OpenAlex
- W2113087764
- Cited by
- 11
- References
- 15
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian rhythm, circadian genes, neuroprotection, molecular clock, astrocyte activation, oxidative stress, redox state, neuronal integrity, gene disruption
- MeSH terms
- Animals, Brain, Circadian Rhythm, Gliosis, Nerve Degeneration, Nerve Tissue Proteins, Neurons, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, CLOCK Proteins, ARNTL Transcription Factors
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