Cited by 754MicroRNA in disease regulationCytokine Signaling Pathways and InteractionsMechanisms of cancer metastasis

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

Open access

Rokavec, Matjaz, Öner, Meryem Gülfem, Li, Huihui, Jackstadt, Rene, Jiang, Longchang, Lodygin, Dmitri, Kaller, Markus, Horst, David, Ziegler, Paul K., Schwitalla, Sarah, Slotta-Huspenina, Julia, Bader, Franz G., Greten, Florian R., Hermeking, Heiko·2014·Journal of Clinical Investigation

DOI 10.1172/jci73531PMC PMC3973098

Open this paper in CoChat — free account

Abstract

Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the early phases of metastasis. Here, we determined that exposure of human colorectal cancer (CRC) cells to the cytokine IL-6 activates the oncogenic STAT3 transcription factor, which directly represses the MIR34A gene via a conserved STAT3-binding site in the first intron. Repression of MIR34A was required for IL-6-induced EMT and invasion. Furthermore, we identified the IL-6 receptor (IL-6R), which mediates IL-6-dependent STAT3 activation, as a conserved, direct miR-34a target. The resulting IL-6R/STAT3/miR-34a feedback loop was present in primary colorectal tumors as well as CRC, breast, and prostate cancer cell lines and associated with a mesenchymal phenotype. An active IL-6R/STAT3/miR-34a loop was necessary for EMT, invasion, and metastasis of CRC cell lines and was associated with nodal and distant metastasis in CRC patient samples. p53 activation in CRC cells interfered with IL-6-induced invasion and migration via miR-34a-dependent downregulation of IL6R expression. In Mir34a-deficient mice, colitis-associated intestinal tumors displayed upregulation of p-STAT3, IL-6R, and SNAIL and progressed to invasive carcinomas, which was not observed in WT animals. Collectively, our data indicate that p53-dependent expression of miR-34a suppresses tumor progression by inhibiting a IL-6R/STAT3/miR-34a feedback loop.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci73531

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED AND REPLACED: microRNA involvement in human cancer
Iorio, M. V., & Croce, C. M. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs140 · Cited by 577
Retracted
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Self-citation
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383
Cancer Metastasis: Building a Framework
Gupta, G. P., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.11.001 · Cited by 4,333
Regulatory networks defining EMT during cancer initiation and progression
Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
Self-citation

Show all 66 references

Research works printed but not linked: 1

Jerry, 1993, Cancer Res., 53, 3374

Sorted by citations

Items 401–500 of 754

One step ahead: miRNA-34 in colon cancer-future diagnostic and therapeutic tool?
Krajewska, J. B., Fichna, J., & Mosińska, P. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.09.006 · Cited by 23
Recent developments in targeting genes and pathways by RNAi‐based approaches in colorectal cancer
Jebelli, A., Baradaran, B., Mosafer, J., Baghbanzadeh, A., Mokhtarzadeh, A., & Tayebi, L. (2020) · Medicinal Research Reviews · doi:10.1002/med.21735 · Cited by 23
LncRNA LINC01116 Promotes the Development of Colorectal Cancer by Targeting miR-9-5p/STMN1
Bi, C., Cui, H., Fan, H., & Li, L. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s253532 · Cited by 23
CYB5R1 links epithelial-mesenchymal transition and poor prognosis in colorectal cancer
Woischke, C., Blaj, C., Schmidt, E. M., Lamprecht, S., Engel, J., Hermeking, H., Kirchner, T., & Horst, D. A. (2016) · Oncotarget · doi:10.18632/oncotarget.8912 · Cited by 23
Self-citation
The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer
Chang, L., Fan, C., Tseng, W., Chein, H., Hsieh, T.-Y., Chen, J., Hwang, C., & Hua, C. (2016) · Disease Markers · doi:10.1155/2016/8143465 · Cited by 22
An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a
Serviss, J. T., Andrews, N., den Eynden, J. V., Richter, F. C., Houtman, M., Vesterlund, M., Schwarzmueller, L., Johnsson, P., Larsson, E., Grandér, D., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0777-5 · Cited by 21
The Association of Simultaneous Increase in Interleukin-6, C Reactive Protein, and Matrix Metalloproteinase-9 Serum Levels with Increasing Stages of Colorectal Cancer
Rašić, I., Rebić, V., Rašić, A., Akšamija, G., & Radović, S. (2018) · Journal of Oncology · doi:10.1155/2018/2830503 · Cited by 22
MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer
Yang, F., Xuan, G., Chen, Y., Cao, L., Zhao, M., Wang, C., & Chen, E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.828128 · Cited by 22
Role of Interleukins in Inflammation-Mediated Tumor Immune Microenvironment Modulation in Colorectal Cancer Pathogenesis
Jain, S. M., Deka, D., Das, A., Paul, S., Pathak, S., & Banerjee, A. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-07972-8 · Cited by 22
Circular RNAs function as competing endogenous RNAs in multiple types of cancer (Review)
Ji, Q., Zhang, C., Sun, X., & Li, Q. (2017) · Oncology Letters · doi:10.3892/ol.2017.7348 · Cited by 22
In-depth analysis of the critical genes and pathways in colorectal cancer
LIU, F., Ji, F., Yu-ling, J., Jiang, Y., Sun, X., Lu, Y., Zhang, L., Han, Y., & Liu, X.-S. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2298 · Cited by 21
C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation
Veschi, V., Verona, F., Bella, S. D., Turdo, A., Gaggianesi, M., Franco, S. D., Mangiapane, L. R., Modica, C., Iacono, M. L., Bianca, P., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02293-y · Cited by 23
miR-944 Suppresses EGF-Induced EMT in Colorectal Cancer Cells by Directly Targeting GATA6
Tang, J., Gao, W., Liu, G., Sheng, W., Zhou, J., Dong, Q., & Dong, M. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s290567 · Cited by 21
Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
Hipólito, A., Martins, F., Mendes, C., Lopes‐Coelho, F., & Serpa, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.656851 · Cited by 21
A Vicious Cycle: In Severe and Critically Ill COVID-19 Patients
Huang, P., Zuo, Q., Li, Y., Oduro, P. K., Tan, F., Wang, Y., Liu, X., Li, J., Wang, Q., Guo, F., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.930673 · Cited by 21
Liujunzi decoction exerts potent antitumor activity in oesophageal squamous cell carcinoma by inhibiting miR-34a/STAT3/IL-6R feedback loop, and modifies antitumor immunity
Han, Y., Fan, X., Fan, L., Wu, Y., Zhou, Z., Wang, G., Guo, L., Gao, W., Chen, Y., & Gao, Q. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154672 · Cited by 23
Cracking the code: Deciphering the role of the tumor microenvironment in osteosarcoma metastasis
Jin, J., Cong, J., Lei, S., Zhang, Q., Zhong, X., Su, Y., Lu, M., Ma, Y., Li, Z., Wang, L., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110422 · Cited by 21
Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial–Mesenchymal Transition
Fang, L., Zhang, L., Wang, M., He, Y., Yang, J., Huang, Z., Tan, Y., Fang, K., Li, J., Sun, Z., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-1693 · Cited by 21
MicroRNAs as Therapeutic Targets and Colorectal Cancer Therapeutics
Yamamoto, H., & Mori, M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-42059-2_13 · Cited by 21
Krüppel like factor 6 splice variant 1 (KLF6-SV1) overexpression recruits macrophages to participate in lung cancer metastasis by up-regulating TWIST1
Wang, J., Wang, X., Wang, Y., Li, S., & Wang, X. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1550570 · Cited by 21
Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications
Donnenberg, A. D., Luketich, J. D., & Donnenberg, V. S. (2019) · Oncotarget · doi:10.18632/oncotarget.27290 · Cited by 21
HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3
Wang, L., Wang, Y., Han, N., Wang, X., & Ruan, M. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112424 · Cited by 20
IL‑6 plays a crucial role in epithelial‑mesenchymal transition and pro‑metastasis induced by sorafenib in liver cancer
Zhang, K., Wang, D., Cai, H., Cao, M., Zhang, Y., Zhuang, P., & Shen, J. (2021) · Oncology Reports · doi:10.3892/or.2021.7926 · Cited by 20
Prognostic significance of chemokines CCL11 and CCL5 modulated by low-density lipoprotein cholesterol in colon cancer patients with normal body mass index
Wang, C., Zou, Y., Pan, C., Shao, L., Ding, Z., Zhang, Y., Ye, J., Li, P., Ren, Y., & Zhu, C. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-1604 · Cited by 20
Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis
Yu, B., Zheng, L., Tang, H., Wang, W., & Lin, Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12349 · Cited by 20
The Molecular Biology of Prostate Cancer Stem Cells: From the Past to the Future
Zhou, Y., Li, T., Jia, M., Dai, R., & Wang, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087482 · Cited by 22
Targeted therapy using nanocomposite delivery systems in cancer treatment: highlighting miR34a regulation for clinical applications
Iqbal, M. J., Javed, Z., Sadia, H., Mehmood, S., Akbar, A., Zahid, B., Nadeem, T., Roshan, S., Varoni, E. M., Iriti, M., et al. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02929-3 · Cited by 22
Identification of key genes involved in JAK/STAT pathway in colorectal cancer
Yue, Y., Zhang, Q., Wu, S., Wang, S., Cui, C., Yu, M., & Sun, Z. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.10.007 · Cited by 20
Glutathione peroxidase 8 expression on cancer cells and cancer‐associated fibroblasts facilitates lung cancer metastasis
Xu, Y., Yuan, L., Jiang, X., Su, M., Huang, M., Chen, Y., Zhang, L., Chen, X., Zhu, H., & Lu, J. (2022) · MedComm · doi:10.1002/mco2.152 · Cited by 18
Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis
Dadgar, N., Sherry, C., Zimmerman, J., Park, H., Lewis, C. M., Donnenberg, A. D., Zaidi, A. H., Fan, Y., Xiao, K., Bartlett, D. L., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05205-8 · Cited by 19
Molecular functions and significance of the MTA family in hormone-independent cancer
Ning, Z., Gan, J., Chen, C., Zhang, D., & Zhang, H. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9517-1 · Cited by 20
CD126 and Targeted Therapy with Tocilizumab in Chronic Lymphocytic Leukemia
Liu, F., Jia, L., Wang, P., Farren, T., Li, H., Hao, X., & Agrawal, S. G. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1139 · Cited by 19
Self-citation
Snail-Modulated MicroRNA 493 Forms a Negative Feedback Loop with the Insulin-Like Growth Factor 1 Receptor Pathway and Blocks Tumorigenesis
Kumar, A. S., Jagadeeshan, S., Pitani, R. S., Ramshankar, V., Kesavan, V., Venkatraman, G., & Rayala, S. K. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00510-16 · Cited by 19
Lung microRNA deregulation associated with impaired alveolarization in rats after intrauterine growth restriction
Dravet-Gounot, P., Morin, C., Jacques, S., Dumont, F., Ely-Marius, F., Vaiman, D., Jarreau, P., Méhats, C., & Zana‐Taïeb, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0190445 · Cited by 19
Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling
Chen, W., Wang, H., Cheng, M., Ni, L., Zou, L., Yang, Q., Cai, X., & Jiao, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.076 · Cited by 19
LPS promote Osteosarcoma invasion and migration through TLR4/HOTAIR
Wang, N., Meng, X., Liu, Y., Chen, Y., & Liang, Q. (2018) · Gene · doi:10.1016/j.gene.2018.09.031 · Cited by 19
LncRNA PAPAS may promote triple-negative breast cancer by downregulating miR-34a
Kong, Y., Geng, C., & Dong, Q. (2019) · Journal of International Medical Research · doi:10.1177/0300060519850724 · Cited by 19
Association of DCBLD2 upregulation with tumor progression and poor survival in colorectal cancer
He, J., Huang, H., Du, Y., Peng, D., Zhou, Y., Li, Y., Wang, H., Zhou, Y., & Nie, Y. (2020) · Cellular Oncology · doi:10.1007/s13402-020-00495-8 · Cited by 19
Mir34a constrains pancreatic carcinogenesis
Hidalgo‐Sastre, A., Lubeseder–Martellato, C., Engleitner, T., Steiger, K., Zhong, S., Desztics, J., Öllinger, R., Rad, R., Schmid, R. M., Hermeking, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66561-1 · Cited by 19
Self-citation
MicroRNA-148a-3p Directly Targets SERPINE1 to Suppress EMT-Mediated Colon Adenocarcinoma Progression
Hu, B., Chen, Z., Wang, X., Chen, F., Song, Z., & Cao, C. (2021) · Cancer Management and Research · doi:10.2147/cmar.s302777 · Cited by 19
B7-H4 is a potential diagnostic and prognostic biomarker in colorectal cancer and correlates with the epithelial-mesenchymal transition
Yan, X., Hong, B., Feng, J., Jin, Y., Chen, M., Li, F., & Qian, Y. (2022) · BMC Cancer · doi:10.1186/s12885-022-10159-5 · Cited by 19
RETRACTED ARTICLE: MicroRNA-216b is Down-Regulated in Human Gastric Adenocarcinoma and Inhibits Proliferation and Cell Cycle Progression by Targeting Oncogene HDAC8
Wang, Y., Xu, P., Yao, J., Yang, R., Shi, Z., Zhu, X., Feng, X., & Gao, S. (2015) · Targeted Oncology · doi:10.1007/s11523-015-0390-9 · Cited by 18
Retracted
Non–small cell lung cancer-derived exosomes promote proliferation, phagocytosis, and secretion of microglia via exosomal microRNA in the metastatic microenvironment
Chen, P., Li, Y., Liu, R., Xie, Y., Jin, Y. T., Wang, M., Yu, Z., Wang, W., & Luo, X. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101594 · Cited by 18
Helicobacter pylori–activated fibroblasts as a silent partner in gastric cancer development
Krzysiek-Mączka, G., Brzozowski, T., & Ptak‐Belowska, A. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10122-1 · Cited by 20
The Role of MicroRNAs in Colorectal Cancer
Kim, S. W. (2017) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2017.69.4.206 · Cited by 18
Hepatitis C virus core protein increases Snail expression and induces epithelial–mesenchymal transition through the signal transducer and activator of transcription 3 pathway in hepatoma cells
Zhou, J., Meng, Z., He, X., Cheng, D., Ye, H., Deng, X., & Chen, R. (2016) · Hepatology Research · doi:10.1111/hepr.12771 · Cited by 18
miR‐181c protects CsA‐induced renal damage and fibrosis through inhibiting EMT
Sun, W., Min, B., Du, D., Yang, F., Junping, M., Wang, W., Zhao, J., Tan, X., Li, Z., & Sun, J. (2017) · FEBS Letters · doi:10.1002/1873-3468.12872 · Cited by 18
Analysis of microRNA-34a expression profile and rs2666433 variant in colorectal cancer: a pilot study
Fawzy, M. S., Ibrahiem, A. T., Alsel, B. T. A., Alghamdi, S. A., & Toraih, E. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-73951-y · Cited by 18
Metformin and Malignant Tumors: Not Over the Hill
Leng, W., Jiang, J., Chen, B., & Wu, Q. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s326378 · Cited by 19
Non-Coding RNA Networks in Pulmonary Hypertension
Zang, H., Zhang, Q., & Li, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.703860 · Cited by 18
The NF-κB-Regulated miR-221/222/Syndecan-1 Axis and Intestinal Mucosal Barrier Function in Radiation Enteritis
Wang, Z., Wang, Q., Gong, L., Liu, T., Wang, P., Yuan, Z., & Wang, W. (2022) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2022.01.006 · Cited by 18
miR-34a and IRE1A/XBP-1(S) Form a Double-Negative Feedback Loop to Regulate Hypoxia-Induced EMT, Metastasis, Chemo-Resistance and Autophagy
Bouznad, N., Rokavec, M., Öner, M. G., & Hermeking, H. (2023) · Cancers · doi:10.3390/cancers15041143 · Cited by 17
Self-citation
Enhancing cancer therapy: The role of drug delivery systems in STAT3 inhibitor efficacy and safety
Wang, K., Zhou, K., Zhong, N., Cao, L., Li, Z., Xiao, Y., Wang, G.-R., Huo, F., Zhou, J., Liu, B., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122635 · Cited by 17
STAT3 and the STAT3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review)
Cortes-Ballinas, L. G., López-Pérez, T. V., & Rocha‐Zavaleta, L. (2024) · Biomedical Reports · doi:10.3892/br.2024.1863 · Cited by 18
Identification of Key Genes in Colorectal Cancer Regulated by miR-34a
Wang, T., Xu, H., Liu, X., Chen, S., Zhou, Y., & Zhang, X. (2017) · Medical Science Monitor · doi:10.12659/msm.904937 · Cited by 17
Temporal characteristics of NF-κB inhibition in blocking bile-induced oncogenic molecular events in hypopharyngeal cells
Doukas, P. G., Vageli, D. P., Doukas, S. G., & Sasaki, C. T. (2019) · Oncotarget · doi:10.18632/oncotarget.26917 · Cited by 17
Intestinal epithelial cell autophagy deficiency suppresses inflammation-associated colon tumorigenesis
Liu, H., Lou, J., Liu, Y., Liu, Z., Xie, J., Sun, J., Pan, H., & Han, W. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.02.012 · Cited by 18
Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells
Lim, J.-H. (2014) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2014.18.5.391 · Cited by 17
MiRNAs as molecular biomarkers in stage II egyptian colorectal cancer patients
Bahnassy, A. A., Salem, S., El-Sayed, M., Khorshid, O., Abdellateif, M. S., Youssef, A. S. E.-D., Mohanad, M., Hussein, M. M., Zekri, A. N., & Allahloubi, N. M. A. (2018) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2018.09.002 · Cited by 17
Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor
Zhou, Y., Xia, Z., Cheng, Z., Xu, G., Yang, X., Liu, S., & Zhu, Y. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005057 · Cited by 17
Novel treatment strategy targeting interleukin-6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer
Mitsui, E., Kikuchi, S., Okura, T., Tazawa, H., Une, Y., Nishiwaki, N., Kuroda, S., Noma, K., Kagawa, S., Ohara, T., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-88033-0 · Cited by 16
Liver Extracellular Matrix in Colorectal Liver Metastasis
Morabito, M., Thibodot, P., Gigandet, A., Compagnon, P., Toso, C., Berishvili, E., Lacotte, S., & Peloso, A. (2025) · Cancers · doi:10.3390/cancers17060953 · Cited by 17
STAT3 Regulates miR-384 Transcription During Th17 Polarization
Han, J., Liu, Y., Zhen, F., Yuan, W., Zhang, W., Song, X., Dong, F., Yao, R., & Qu, X. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00253 · Cited by 16
Enhanced Expression of miR‐34a Enhances Escherichia coli Lipopolysaccharide‐Mediated Endometritis by Targeting LGR4 to Activate the NF‐κB Pathway
Ma, X., Yin, B., Guo, S., Umar, T., Liu, J., Wu, Z., Zhou, Q., Zahoor, A., & Deng, G. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1744754 · Cited by 16
Tackling the Threat of Cancer Due to Pathobionts Producing Colibactin: Is Mesalamine the Magic Bullet?
Tang-Fichaux, M., Branchu, P., Nougayrède, J., & Oswald, É. (2021) · Toxins · doi:10.3390/toxins13120897 · Cited by 18
The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
Gu, W., Shen, H., Xie, L., Zhang, X., & Yang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.800140 · Cited by 14
Changes of serum miR34a expression during neoadjuvant chemotherapy predict the treatment response and prognosis in stage II/III breast cancer
Liu, B., Su, F., Li, Y., Qi, X., Liu, X., Liang, W., You, K., Zhang, Y., & Zhang, J. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.133 · Cited by 16
Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma
Bao, Y., Zhang, S., Guo, Y., Wei, X., Zhang, Y., Yang, Y., Zhang, H., Ma, M., & Yang, W. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1843-2 · Cited by 16
Circulating miR34a levels as a potential biomarker in the follow-up of Ewing sarcoma
Sciandra, M., Feo, A. D., Parra, A., Landuzzi, L., Lollini, P., Manara, M. C., Mattia, G., Pontecorvi, G., Baricordi, C., Guerzoni, C., et al. (2020) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-020-00567-2 · Cited by 16
Differentially expressed miRNAs in hepatocellular carcinoma cells under hypoxic conditions are associated with transcription and phosphorylation
Hu, B., Tang, W., Fan, J., Xu, Y., & Sun, H. (2017) · Oncology Letters · doi:10.3892/ol.2017.7349 · Cited by 16
The genetic script of metastasis
Jinesh, G. G., & Brohl, A. S. (2019) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12562 · Cited by 16
Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression
Kim, S. J., García‐Recio, S., Creighton, C. J., Perou, C. M., & Rosen, J. M. (2019) · Oncogene · doi:10.1038/s41388-019-0852-0 · Cited by 16
Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway
Zhang, Y., Chen, F., Xiao, X., Pan, W., Yuan, Q., & Cao, J. (2019) · Cancer Management and Research · doi:10.2147/cmar.s193647 · Cited by 15
MicroRNA-34a deficiency leads to impaired wound closure by augmented inflammation in mice
Zhao, N., Wang, G., Long, S., Hu, M., Gao, J., Ran, X., Wang, J., Su, Y., & Wang, T. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.03.161 · Cited by 15
Src-FAK Signaling Mediates Interleukin 6-Induced HCT116 Colorectal Cancer Epithelial–Mesenchymal Transition
Huang, Y., Chen, H., Hsu, Y., Chen, H.-C., Chuang, C.-H., Huang, S., & Hsu, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076650 · Cited by 15
Tumor-derived IL-6 promotes chordoma invasion by stimulating tumor-associated macrophages M2 polarization and TNFα secretion
Chen, Y., Guo, Y., Li, S., Xu, J., Zhao, C., Wang, J., Yang, J., Ning, W., Qu, Y., Zhang, M., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113315 · Cited by 15
Pharmacological and Immunological Targeting of Tumor Mesenchymalization
David, J., Dominguez, C. L., & Palena, C. (2016) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2016.11.011 · Cited by 14
Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively
Lin, W., Zou, H., Mo, J., Jin, C., Jiang, H., Yu, C., Jiang, Z., Yang, Y., He, B., & Wang, K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.637878 · Cited by 15
RETRACTED ARTICLE: miR-217-5p Inhibits Invasion and Metastasis of Prostate Cancer by Targeting Clusterin
Zhao, W., Wang, X., Jiang, Y., Jia, X., & Guo, Y. (2021) · Mammalian Genome · doi:10.1007/s00335-021-09874-4 · Cited by 15
Retracted
Na+/H+-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer
Zhou, X., Jiang, M., Liu, Z., Xu, M., Chen, N., Wu, Z., Gu, C., Chin, E. Y., & Yang, X. (2021) · Journal of Oncology · doi:10.1155/2021/3241351 · Cited by 14
Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways
Huang, A., Wang, R., Cui, J., Gao, Y., Yin, Z., Chen, L., He, M., & Li, W. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.808152 · Cited by 15
Histone methyltransferase KMT2D promotes prostate cancer progression through paracrine IL-6 signaling
Zhang, J., Ye, Y., Xu, Z., Luo, M., Wu, C., Zhang, Y., Lv, S., & Wei, Q. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.02.083 · Cited by 15
Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases
Faggioli, F., Velarde, M. C., & Wiley, C. D. (2023) · Cells · doi:10.3390/cells12060860 · Cited by 15
Cancer Stem Cells are Regulated by STAT3 Signalling in Wilms Tumour
Liu, Y., Gao, X., Wang, S., Yuan, X., Pang, Y., Chen, J., & Wang, J. (2018) · Journal of Cancer · doi:10.7150/jca.23277 · Cited by 15
Cancer evolution: Special focus on the immune aspect of cancer
Hu, X., Chen, Z., Wang, Z., & Xiao, Q. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.05.006 · Cited by 14
Harmine suppresses breast cancer cell migration and invasion by regulating TAZ-mediated epithelial-mesenchymal transition.
He, J., Chen, S., Yu, T., Chen, W., Huang, J., Peng, C., & Ding, Y. (2022) · PubMed Central · Cited by 14
Non‐coding RNAs and colitis‐associated cancer: Mechanisms and clinical applications
Gu, Y., Zhao, H., Zheng, L., Zhou, C., Han, Y., Wu, A., Jia, Z., Xia, T., & Zhi, Q. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1253 · Cited by 14
Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3
Yu, J., Yang, H., Zhang, L., Ran, S., Shi, Q., Peng, P., Liu, Q., & Song, L. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03195-x · Cited by 14
Osteosarcopenia: the coexistence of sarcopenia and osteopenia is predictive of prognosis and postoperative complications after curative resection for colorectal cancer
Fujimoto, T., Tamura, K., Nagayoshi, K., Mizuuchi, Y., Oh, Y., Nara, T., Matsumoto, H., Horioka, K., Shindo, K., Nakata, K., et al. (2024) · Surgery Today · doi:10.1007/s00595-024-02883-1 · Cited by 14
L‑fucose ameliorates the carcinogenic properties of Fusobacterium nucleatum in colorectal cancer
Duan, C., Tang, X., Wang, W., Qian, W., Fu, X., Deng, X., Han, C., & Hou, X. (2020) · Oncology Letters · doi:10.3892/ol.2020.12404 · Cited by 14
CXCL14 facilitates the growth and metastasis of ovarian carcinoma cells via activation of the Wnt/β-catenin signaling pathway
Gao, L., Hao, M., Liu, X., Zhang, L., Dong, Y., Zhang, Y., & He, X. (2021) · Journal of Ovarian Research · doi:10.1186/s13048-021-00913-x · Cited by 14
Circular RNA circ_0047744 suppresses the metastasis of pancreatic ductal adenocarcinoma by regulating the miR-21/SOCS5 axis
Xie, H., Zhao, Q., Yu, L., Lu, J., Peng, K., Xie, N., Ni, J., & Li, B. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.082 · Cited by 14
Silencing ofEag1Gene Inhibits Osteosarcoma Proliferation and Migration by Targeting STAT3-VEGF Pathway
Wu, X., Chen, Z., Zeng, W., Zhong, Y., Liu, Q., & Wu, J. (2015) · BioMed Research International · doi:10.1155/2015/617316 · Cited by 15
The Role of Non-Coding RNAs in Autophagy During Carcinogenesis
de la Cruz‐Ojeda, P., Flores-Campos, R., Navarro‐Villarán, E., & Muntané, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.799392 · Cited by 14
The multifaceted role of microRNAs in colorectal cancer: pathogenesis and therapeutic implications
Longo, F., Gattuso, G., Spoto, G., Ricci, D., Vitale, A. C. V., Lavoro, A., Candido, S., Libra, M., & Falzone, L. (2025) · Non-coding RNA Research · doi:10.1016/j.ncrna.2025.05.012 · Cited by 17
Prognostic significance of osteosarcopenia in older adults with colorectal cancer
Takano, Y., Kodera, K., Tsukihara, S., Takahashi, S., Kobayashi, Y., Koyama, M., Kanno, H., Ishiyama, S., Saito, R., Hanyu, N., et al. (2023) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12663 · Cited by 13
Acetyl-cinobufagin suppresses triple-negative breast cancer progression by inhibiting the STAT3 pathway
Qi, Y., Wu, H., Zhu, T., Liu, Z., Liu, C., Yan, C., Wu, Z., Xu, Y., Bai, Y., Yang, L., et al. (2023) · Aging · doi:10.18632/aging.204967 · Cited by 13
Hsa_circ_0020134 promotes liver metastasis of colorectal cancer through the miR-183-5p-PFN2-TGF-β/Smad axis
Yu, J.-H., Tan, J.-N., Zhong, G., Zhong, L., Hou, D., Ma, S., Wang, P., Zhang, Z., Lu, X.-Q., Yang, B., et al. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101823 · Cited by 13
Myeloid Mir34a suppresses colitis-associated colon cancer: characterization of mediators by single-cell RNA sequencing
König, J., Rokavec, M., Öner, M. G., Fei, Y., & Hermeking, H. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01380-9 · Cited by 13
Self-citation
MicroRNA-33b inhibits tumor cell growth and is associated with prognosis in colorectal cancer patients
Liao, W.-R., Gu, C., Huang, A., Yao, J., & Sun, R. (2015) · Clinical & Translational Oncology · doi:10.1007/s12094-015-1388-6 · Cited by 13

Authors: Rokavec, M., Öner, M. G., Li, H., Jackstadt, R., Jiang, L., Lodygin, D., Kaller, M., Horst, D., Ziegler, P. K., Schwitalla, S., Slotta-Huspenina, J., Bader, F. G., Greten, F. R., & Hermeking, H.
Affiliations: TUM Klinikum (DE)
Pathologisches Institut (DE)
Universitätsmedizin Göttingen (DE)
German Cancer Research Center (DE)
ORCID: Öner, Meryem Gülfem
Li, Huihui
Kaller, Markus
Horst, David
Ziegler, Paul K.
Greten, Florian R.
Hermeking, Heiko
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2014-03-18
Volume: 124
Issue: 4
Pages: 1853-1867
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci73531
PMC: PMC3973098
OpenAlex: W2104268053
Cited by: 753
References: 66
Citations by year: 2026: 17 · 2025: 29 · 2024: 60 · 2023: 66 · 2022: 90 · 2021: 69 · 2020: 66 · 2019: 76 · 2018: 59 · 2017: 69 · 2016: 65 · 2015: 66 · 2014: 20
FWCI: 23.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
mediaTUM (Technical University of Munich) (submittedVersion)
GRO (submittedVersion)
Funders: Johns Hopkins University (HCT116)
Deutsche Forschungsgemeinschaft
Deutsche Krebshilfe
Deutschen Konsortium für Translationale Krebsforschung
FP7 Ideas: European Research Council (281967)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords: colorectal cancer, epithelial-mesenchymal transition, interleukin-6, IL-6 receptor, STAT3, miR-34a, feedback loops, tumor invasion, metastasis, p53, snails, microRNA regulation
MeSH terms: Snail Family Transcription Factors, Animals, Disease Models, Animal, Female, Humans, Male, Neoplasm Invasiveness, Neoplasm Metastasis, Transcription Factors, Colorectal Neoplasms, Mice, Knockout, Receptors, Interleukin-6, Feedback, Physiological, MicroRNAs, Cell Line, Tumor, STAT3 Transcription Factor, Mice, Epithelial-Mesenchymal Transition

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks