The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment
Open accessAbstract
In many organs, including the intestine and skin, cancers originate from cells of the stem or progenitor compartment. Despite its nomenclature, the cellular origin of hepatocellular carcinoma (HCC) remains elusive. In contrast to most organs, the liver lacks a defined stem cell population for organ maintenance. Previous studies suggest that both hepatocytes and facultative progenitor cells within the biliary compartment are capable of generating HCC. As HCCs with a progenitor signature carry a worse prognosis, understanding the origin of HCC is of clinical relevance. Here, we used complementary fate-tracing approaches to label the progenitor/biliary compartment and hepatocytes in murine hepatocarcinogenesis. In genotoxic and genetic models, HCCs arose exclusively from hepatocytes but never from the progenitor/biliary compartment. Cytokeratin 19-, A6- and α-fetoprotein-positive cells within tumors were hepatocyte derived. In summary, hepatocytes represent the cell of origin for HCC in mice, and a progenitor signature does not reflect progenitor origin, but dedifferentiation of hepatocyte-derived tumor cells.
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Cites
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Self-citationPromotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
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Self-citationHippo Pathway Activity Influences Liver Cell Fate
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Self-citationThe immunological and metabolic landscape in primary and metastatic liver cancer
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Metadata
- Authors
- Mu, X., Español-Suñer, R., Mederacke, I., Affò, S., Manco, R., Sempoux, C., Lemaigre, F. P., Adili, A., Yuan, D., Weber, A., Unger, K., Heikenwälder, M., Leclercq, I. A., & Schwabe, R. F.
- Venue
- Journal of Clinical Investigation
- Published
- 2015-09-08
- Volume
- 125
- Issue
- 10
- Pages
- 3891-3903
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2165802669
- Cited by
- 215
- References
- 12
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Mu, X., Español-Suñer, R., Mederacke, I., Affò, S., Manco, R., Sempoux, C., Lemaigre, F. P., Adili, A., Yuan, D., Weber, A., Unger, K., Heikenwälder, M., Leclercq, I. A., & Schwabe, R. F. (2015). Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment. Journal of Clinical Investigation. https://doi.org/10.1172/jci77995
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
