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Cited by 155T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesPsoriasis: Treatment and Pathogenesis

T cells in the control of organ-specific autoimmunity

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Bluestone, Jeffrey A., Bour-Jordan, Hélène, Cheng, Mickie, Anderson, Mark·2015·Journal of Clinical Investigation
DOI 10.1172/jci78089PMC PMC4497750
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Abstract

Immune tolerance is critical to the avoidance of unwarranted immune responses against self antigens. Multiple, non-redundant checkpoints are in place to prevent such potentially deleterious autoimmune responses while preserving immunity integral to the fight against foreign pathogens. Nevertheless, a large and growing segment of the population is developing autoimmune diseases. Deciphering cellular and molecular pathways of immune tolerance is an important goal, with the expectation that understanding these pathways will lead to new clinical advances in the treatment of these devastating diseases. The vast majority of autoimmune diseases develop as a consequence of complex mechanisms that depend on genetic, epigenetic, molecular, cellular, and environmental elements and result in alterations in many different checkpoints of tolerance and ultimately in the breakdown of immune tolerance. The manifestations of this breakdown are harmful inflammatory responses in peripheral tissues driven by innate immunity and self antigen-specific pathogenic T and B cells. T cells play a central role in the regulation and initiation of these responses. In this Review we summarize our current understanding of the mechanisms involved in these fundamental checkpoints, the pathways that are defective in autoimmune diseases, and the therapeutic strategies being developed with the goal of restoring immune tolerance.

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  • In autoimmunity, self-reactive T cells acquire cytotoxic effector functions and cause destruction of self.

    “In autoimmunity, self-reactive T cells acquire cytotoxic effector functions and cause destruction of self1.”

    From An autoimmune stem-like CD8 T cell population drives type 1 diabetes (2022) · cites this paper as [1]

    The Conclusion (Figure 1; page unavailable) says autoreactive T cells are more prone to activation in autoimmune disease and that autoreactive ex-Foxp3 cells may contribute to tissue destruction. It describes those cells producing pro-inflammatory cytokines, but does not establish that self-reactive T cells acquire cytotoxic effector functions as the claim specifies. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance mechanisms in autoreactive CD8 T cells.

    “CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance mechanisms in autoreactive CD8 T cells1.”

    From An autoimmune stem-like CD8 T cell population drives type 1 diabetes (2022) · cites this paper as [1]

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Cited by

Sorted by citations

Authors
Bluestone, J. A., Bour-Jordan, H., Cheng, M., & Anderson, M.
Affiliations
University of California, San Francisco (US)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2015-05-18
Volume
125
Issue
6
Pages
2250-2260
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci78089
PMC
PMC4497750
OpenAlex
W1521946365
Cited by
155
References
10
Citations by year
2026: 9 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 19 · 2020: 19 · 2019: 14 · 2018: 16 · 2017: 14 · 2016: 14 · 2015: 5
FWCI
1.54
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (R01AI097457, R01AI046643)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK101622)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
T cells, organ-specific autoimmunity, immune tolerance, autoimmune disease pathogenesis, B cells, innate immunity, autoimmune disease therapy
MeSH terms
Animals, Autoimmune Diseases, B-Lymphocytes, Humans, Immune Tolerance, Immunity, Innate, Organ Specificity, T-Lymphocytes, Autoimmunity

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