Type 1 diabetes immunotherapy using polyclonal regulatory T cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835 · see citing works

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608 · see citing works

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606 · see citing works

Genetics, pathogenesis and clinical interventions in type 1 diabetes

Bluestone, J. A., Herold, K., & Eisenbarth, G. (2010) · Nature · doi:10.1038/nature08933 · Cited by 1,265 · see citing works

Current state of type 1 diabetes treatment in the U.S.: updated data from the T1D Exchange clinic registry

Miller, K. M., Foster, N. C., Beck, R. W., Bergenstal, R. M., DuBose, S. N., DiMeglio, L. A., Maahs, D. M., & Tamborlane, W. V. (2015) · Diabetes Care · doi:10.2337/dc15-0078 · Cited by 1,254 · see citing works

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

Tang, Q., Henriksen, K., Bi, M., Finger, E. B., Szot, G. L., Ye, J., Masteller, E. L., McDevitt, H. O., Bonyhadi, M. L., & Bluestone, J. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040139 · Cited by 1,219 · see citing works

Standardizing immunophenotyping for the Human Immunology Project

Maecker, H. T., McCoy, J. P., & Nussenblatt, R. B. (2012) · Nature reviews. Immunology · doi:10.1038/nri3158 · Cited by 1,183 · see citing works

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

Brunstein, C. G., Miller, J. S., Cao, Q., McKenna, D. H., Hippen, K. L., Curtsinger, J., DeFor, T. E., Levine, B. L., June, C. H., Rubinstein, P., et al. (2010) · Blood · doi:10.1182/blood-2010-07-293795 · Cited by 1,052 · see citing works

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

Tang, Q., & Bluestone, J. A. (2008) · Nature Immunology · doi:10.1038/ni1572 · Cited by 1,026 · see citing works

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

Tang, Q., Adams, J. Y., Penaranda, C., Melli, K., Piaggio, E., Sgouroudis, E., Piccirillo, C. A., Salomon, B. L., & Bluestone, J. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.016 · Cited by 729 · see citing works

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells

Baron, U., Floess, S., Wieczorek, G., Baumann, K., Grützkau, A., Dong, J., Thiel, A., Boeld, T. J., Hoffmann, P., Edinger, M., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200737594 · Cited by 694 · see citing works

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases

Klatzmann, D., & Abbas, A. (2015) · Nature reviews. Immunology · doi:10.1038/nri3823 · Cited by 632 · see citing works

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

Voltarelli, J. C., Couri, C. E. B., Stracieri, A. B. P. L., Oliveira, M. C., Moraes, D. A., Pieroni, F., Coutinho, M., Malmegrim, K. C. R., Foss-Freitas, M. C., Simões, B. P., et al. (2007) · JAMA · doi:10.1001/jama.297.14.1568 · Cited by 573 · see citing works

Defective regulatory and effector T cell functions in patients with FOXP3 mutations

Bacchetta, R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25112 · Cited by 511 · see citing works

CD4 + CD25 + T regulatory cells control anti-islet CD8 + T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

Green, E. A., Gorelik, L., McGregor, C. M., Tran, E. H., & Flavell, R. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834400100 · Cited by 446 · see citing works

Administration of CD4+CD25highCD127-regulatory T cells preserves β-cell function in type 1 diabetes in children

Marek-Trzonkowska, N., Myśliwiec, M., Dobyszuk, A., Grabowska, M., Techmańska, I., Juścińska, J., Wujtewicz, M. A., Witkowski, P., Młynarski, W., Balcerska, A., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0038 · Cited by 431 · see citing works

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

McClymont, S. A., Putnam, A. L., Lee, M. R., Esensten, J. H., Liu, W., Hulme, M. A., Hoffmüller, U., Baron, U., Olek, S., Bluestone, J. A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003099 · Cited by 428 · see citing works

Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled Trial

Herold, K. C., Gitelman, S. E., Ehlers, M. R., Gottlieb, P. A., Greenbaum, C. J., Hagopian, W., Boyle, K. D., Keyes-Elstein, L., Aggarwal, S., Phippard, D., et al. (2013) · Diabetes · doi:10.2337/db13-0345 · Cited by 410 · see citing works

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

Marek-Trzonkowska, N., Myśliwiec, M., Dobyszuk, A., Grabowska, M., Derkowska, I., Juścińska, J., Owczuk, R., Szadkowska, A., Witkowski, P., Młynarski, W., et al. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.03.016 · Cited by 384 · see citing works

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (T regs ) with Minimal Loss of in Vivo Functional Activity

Hippen, K. L., Merkel, S. C., Schirm, D. K., Sieben, C. M., Sumstad, D., Kadidlo, D. M., McKenna, D. H., Bromberg, J. S., Levine, B. L., Riley, J. L., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001809 · Cited by 367 · see citing works

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

Putnam, A. L., Brusko, T. M., Lee, M. R., Liu, W., Szot, G. L., Ghosh, T., Atkinson, M. A., & Bluestone, J. A. (2008) · Diabetes · doi:10.2337/db08-1168 · Cited by 357 · see citing works

Glycaemic control of Type 1 diabetes in clinical practice early in the 21st century: an international comparison

McKnight, J. A., Wild, S. H., Lamb, M. J. E., Cooper, M. N., Jones, T. W., Davis, E. A., Hofer, S., Fritsch, M., Schober, E., Svensson, J., et al. (2015) · Diabetic Medicine · doi:10.1111/dme.12676 · Cited by 343 · see citing works

Fall in C-Peptide During First 2 Years From Diagnosis

Greenbaum, C. J., Beam, C. A., Boulware, D., Gitelman, S. E., Gottlieb, P. A., Herold, K. C., Lachin, J. M., McGee, P., Palmer, J. P., Pescovitz, M. D., et al. (2012) · Diabetes · doi:10.2337/db11-1538 · Cited by 319 · see citing works

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function

Long, S. A., Rieck, M., Sanda, S., Bollyky, J., Samuels, P. L., Goland, R., Ahmann, A., Rabinovitch, A., Aggarwal, S., Phippard, D., et al. (2012) · Diabetes · doi:10.2337/db12-0049 · Cited by 315 · see citing works

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.

Hall, B. M., PEARCE, N. W., Gurley, K. E., & Dorsch, S. E. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.1.141 · Cited by 297 · see citing works

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

Long, S. A., Cerosaletti, K. M., Bollyky, P. L., Tatum, M., Shilling, H. G., Zhang, S., Zhang, Z., Pihoker, C., Sanda, S., Greenbaum, C. J., et al. (2009) · Diabetes · doi:10.2337/db09-0694 · Cited by 284 · see citing works

Peripheral CD4+CD8+ T cells are differentiated effector memory cells with antiviral functions

Nascimbeni, M., Shin, E., Chiriboga, L. A., Kleiner, D. E., & Rehermann, B. (2004) · Blood · doi:10.1182/blood-2003-12-4395 · Cited by 263 · see citing works

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

Putnam, A. L., Safinia, N., Medvec, A. R., Laszkowska, M., Wray, M., Mintz, M. A., Trotta, E., Szot, G. L., Liu, W., Lares, A., et al. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12433 · Cited by 262 · see citing works

Regulatory T-Cell Therapy in Transplantation: Moving to the ClinicPreprint

Tang, Q., & Bluestone, J. A. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015552 · Cited by 233 · see citing works

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

Rigby, M. R., DiMeglio, L. A., Rendell, M., Felner, E. I., Dostou, J. M., Gitelman, S. E., Patel, C. M., Griffin, K., Tsalikian, E., Gottlieb, P. A., et al. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70111-6 · Cited by 209 · see citing works

Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies in vitro , in animals, and in humans

Macallan, D. C., Fullerton, C. A., Neese, R. A., Haddock, K., Park, S. S., & Hellerstein, M. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.708 · Cited by 190 · see citing works

Measurement of cell proliferation by heavy water labeling

Busch, R., Neese, R. A., Awada, M., Hayes, G. M., & Hellerstein, M. K. (2007) · Nature Protocols · doi:10.1038/nprot.2007.420 · Cited by 184 · see citing works

Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes

Haller, M. J., Gitelman, S. E., Gottlieb, P. A., Michels, A. W., Rosenthal, S. M., Shuster, J. J., Zou, B., Brusko, T. M., Hulme, M. A., Wasserfall, C. H., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78492 · Cited by 167 · see citing works

Survival and Tumor Localization of Adoptively Transferred Melan-A-Specific T Cells in Melanoma Patients

Meidenbauer, N., Marienhagen, J., Laumer, M., Vogl, S., Heymann, J., Andreesen, R., & Mackensen, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2161 · Cited by 157 · see citing works

T cells in the control of organ-specific autoimmunity

Bluestone, J. A., Bour-Jordan, H., Cheng, M., & Anderson, M. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78089 · Cited by 155 · see citing works

CD56negCD16+NK cells are activated mature NK cells with impaired effector function during HIV-1 infection

Milush, J. M., López‐Vergès, S., York, V. A., Deeks, S. G., Martin, J. N., Hecht, F. M., Lanier, L. L., & Nixon, D. F. (2013) · Retrovirology · doi:10.1186/1742-4690-10-158 · Cited by 120 · see citing works

Regulatory T cells: stability revisited

Bailey-Bucktrout, S. L., & Bluestone, J. A. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.002 · Cited by 104 · see citing works

The therapeutic potential of regulatory T cells for the treatment of autoimmune disease

Bluestone, J. A., Trotta, E., & Xu, D. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1037282 · Cited by 92 · see citing works

Harnessing FOXP3+ regulatory T cells for transplantation tolerance

Waldmann, H., Hilbrands, R., Howie, D., & Cobbold, S. (2014) · Journal of Clinical Investigation · doi:10.1172/jci67226 · Cited by 69 · see citing works

Targeted Disruption of CD38 Accelerates Autoimmune Diabetes in NOD/Lt Mice by Enhancing Autoimmunity in an ADP-Ribosyltransferase 2-Dependent Fashion

Chen, J., Chen, Y., Reifsnyder, P. C., Schott, W. H., Lee, C., Osborne, M. A., Scheuplein, F., Haag, F., Koch‐Nolte, F., SERREZE, D. V., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4590 · Cited by 64 · see citing works

Dominant Th2 Differentiation of Human Regulatory T Cells upon Loss of FOXP3 Expression

Hansmann, L., Schmidl, C., Kett, J., Steger, L., Andreesen, R., Hoffmann, P., Rehli, M., & Edinger, M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102288 · Cited by 63 · see citing works

CCL-21 Conditioned Regulatory T Cells Induce Allotolerance through Enhanced Homing to Lymphoid Tissue

Chauhan, S. K., Saban, D. R., Dohlman, T. H., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203469 · Cited by 48 · see citing works

Targeting Memory T Cells in Type 1 Diabetes

Ehlers, M. R., & Rigby, M. R. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0659-5 · Cited by 40 · see citing works

Assessment of Suppressive Capacity by Human Regulatory T Cells Using a Reproducible, Bi-Directional CFSE-Based In Vitro Assay

Schneider, A., & Buckner, J. H. (2011) · Methods in molecular biology · doi:10.1007/978-1-61737-979-6_15 · Cited by 18 · see citing works

Type 1 diabetes

DiMeglio, L. A., Evans-Molina, C., & Oram, R. A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31320-5 · Cited by 1,561 · see citing works

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726 · see citing works

The regulation of immune tolerance by FOXP3

Lu, L., Barbi, J., & Pan, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.75 · Cited by 580 · see citing works

Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity

Romano, M., Fanelli, G., Albany, C. J., Giganti, G., & Lombardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00043 · Cited by 512 · see citing works

Advances in islet encapsulation technologies

Desai, T., & Shea, L. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.232 · Cited by 427 · see citing works

New frontiers in the treatment of type 1 diabetes

Warshauer, J. T., Bluestone, J. A., & Anderson, M. S. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.017 · Cited by 259 · see citing works

Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?

Hull, C. M., Peakman, M., & Tree, T. I. M. (2017) · Diabetologia · doi:10.1007/s00125-017-4377-1 · Cited by 194 · see citing works

The journey of islet cell transplantation and future development

Gamble, A., Pepper, A. R., Bruni, A., & Shapiro, A. M. J. (2018) · Islets · doi:10.1080/19382014.2018.1428511 · Cited by 171 · see citing works

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

Yoon, J., Schmidt, A., Zhang, A.-H., Königs, C., Kim, Y. C., & Scott, D. W. (2017) · Blood · doi:10.1182/blood-2016-07-727834 · Cited by 150 · see citing works

Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function

Huang, J., Wang, L., Dahiya, S., Beier, U. H., Han, R., Samanta, A., Bergman, J., Sotomayor, E. M., Seto, E., Kozikowski, A. P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09211-3 · Cited by 96 · see citing works

The role of CD4⁺FoxP3⁺ regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment

Wang, Y., Zheng, J., Islam, M. S., Yang, Y., Hu, Y., & Chen, X. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59534 · Cited by 71 · see citing works

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials

Esensten, J. H., Bluestone, J. A., & Lim, W. A. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100304 · Cited by 62 · see citing works

Mitochondria-Derived Peptide MOTS-c: Effects and Mechanisms Related to Stress, Metabolism and Aging

Wan, W., Zhang, L., Lin, Y., Rao, X., Wang, X., Hua, F., & Ying, J. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03885-2 · Cited by 70 · see citing works

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Li, G., Wan, Y., Jiao, A., Jiang, K., Cui, G., Tang, J., Yu, S., Hu, Z., Zhao, S., Yi, Z., et al. (2025) · Med Research · doi:10.1002/mdr2.70007 · Cited by 63 · see citing works

Gene therapy with regulatory T cells: A beneficial alliance

Biswas, M., Kumar, S. R. P., Terhorst, C., & Herzog, R. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00554 · Cited by 41 · see citing works

Increased islet antigen–specific regulatory and effector CD4 ⁺ T cells in healthy individuals with the type 1 diabetes–protective haplotype

Wen, X., Yang, J., James, E., Chow, I.-T., Reijonen, H., & Kwok, W. W. (2020) · Science Immunology · doi:10.1126/sciimmunol.aax8767 · Cited by 35 · see citing works

CD4+ T cells engineered with FVIII-CAR and murine Foxp3 suppress anti-factor VIII immune responses in hemophilia a mice

Fu, R. Y., Chen, A. C., Lyle, M. J., Chen, C.-Y., Liu, C. L., & Miao, C. H. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104216 · Cited by 34 · see citing works

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

MacDonald, K. N., Ivison, S., Hippen, K. L., Hoeppli, R. E., Hall, M., Zheng, G., Dijke, I. E., Aklabi, M. A., Freed, D. H., Rebeyka, I., et al. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2019.10.011 · Cited by 30 · see citing works

Functional heterogeneity of CD4+ T cells in liver inflammation

Muscate, F., Woestemeier, A., & Gagliani, N. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00881-w · Cited by 32 · see citing works

Quantitative increase in T regulatory cells enhances bone remodeling in osteogenesis imperfecta

Kang, I.-H., Baliga, U. K., Chatterjee, S., Chakraborty, P., Choi, S., Buchweitz, N., Li, H., Wu, Y., Yao, H., Mehrotra, S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104818 · Cited by 28 · see citing works

Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice

Herzog, R. W., Kuteyeva, V., Saboungi, R., Terhorst, C., & Biswas, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00274 · Cited by 24 · see citing works

CAR-Treg cell therapies and their future potential in treating ocular autoimmune conditions

Abraham, A. R., Maghsoudlou, P., Copland, D. A., Nicholson, L. B., & Dick, A. D. (2023) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1184937 · Cited by 20 · see citing works

Regulatory T Cells: Central Concepts from Ontogeny to Therapy

Khor, B. (2017) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2016.07.003 · Cited by 15 · see citing works

Analysis of LAP+ and GARP+ Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders

Cai, H., Liu, Y., Dong, X., Jiang, F., Li, H., Ouyang, S., Yin, W., He, T., Zeng, Q., & Yang, H. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06629-8 · Cited by 11 · see citing works

Preparation Optimization of Polyclonal Antibodies Against Three Important Enzymes

Li-mi, W. (2014) · Strait Pharmaceutical Journal

Production of human polyclonal antibodies by transgenic animals

Houdebine, L. (2011) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2011.23022 · Cited by 16 · see citing works

Preparation and characterization of polyclonal antibody against human glypican3 N-terminal protein

Minxing, Z. (2010) · Journal of Nantong University

Preparation and preliminary detection of polyclonal antibody against the causal agent of sugarcane ratoon stunting disease

Hai-hua, D. (2012) · Guangdong nongye kexue

Generation and preliminary application of rabbit antihuman polyclonal antibodies against DR5

Ma, Y. (2008) · Immunological Journal