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Cited by 1,050

The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

Open access
Marvel, Douglas, Gabrilovich, Dmitry I.·2015·Journal of Clinical Investigation

Abstract

Our understanding of the role of myeloid-derived suppressor cells (MDSCs) in cancer is becoming increasingly complex. In addition to their eponymous role in suppressing immune responses, they directly support tumor growth, differentiation, and metastasis in a number of ways that are only now beginning to be appreciated. It is because of this increasingly complex role that these cells may become an important factor in the treatment of human cancer. In this Review, we discuss the most pertinent and controversial issues of MDSC biology and their role in promoting cancer progression and highlight how these cells may be used in the clinic, both as prognostic factors and as therapeutic targets.

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Metadata

Authors
Marvel, D., & Gabrilovich, D. I.
Venue
Journal of Clinical Investigation
Published
2015-07-13
Volume
125
Issue
9
Pages
3356-3364
ISSN
0021-9738 (ISSN-L)
OpenAlex
W1927075449
Cited by
1,050
References
122
FWCI
48.09
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. https://app.cochat.ai/papers/10.1172/jci80005
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Marvel, D., & Gabrilovich, D. I. (2015). Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. Journal of Clinical Investigation. https://doi.org/10.1172/jci80005

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.