The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages
Open accessAbstract
The generation of an inflammatory environment is favorable and often decisive for the growth of both primary tumors and metastases. Tumor cells either express membrane molecules or release tumor-derived soluble factors able to alter myelopoiesis. Tumor-reprogrammed myeloid cells not only create a tolerogenic environment by blocking T cell functions and proliferation, but also directly drive tumor growth by promoting cancer stemness, angiogenesis, stroma deposition, epithelial-to-mesenchymal transition, and metastasis formation. In this Review, we discuss the interplay between immunosuppressive and protumoral myeloid cells and detail their immune-regulatory mechanisms, the molecular pathways involved in their differentiation, as well as their potential role as prognostic and diagnostic biomarkers and prospective targets for innovative approaches to treat tumor-bearing hosts.
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Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment
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Cancer immunoediting and resistance to T cell-based immunotherapy
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Metadata
- Authors
- Ugel, S., De Sanctis, F., Mandruzzato, S., & Bronte, V.
- Venue
- Journal of Clinical Investigation
- Published
- 2015-09-01
- Volume
- 125
- Issue
- 9
- Pages
- 3365-3376
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1921451985
- Cited by
- 559
- References
- 160
- FWCI
- 20.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ugel, S., De Sanctis, F., Mandruzzato, S., & Bronte, V. (2015). Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. Journal of Clinical Investigation. https://doi.org/10.1172/jci80006
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