The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Therapeutic cancer vaccines
Open accessAbstract
The clinical benefit of therapeutic cancer vaccines has been established. Whereas regression of lesions was shown for premalignant lesions caused by HPV, clinical benefit in cancer patients was mostly noted as prolonged survival. Suboptimal vaccine design and an immunosuppressive cancer microenvironment are the root causes of the lack of cancer eradication. Effective cancer vaccines deliver concentrated antigen to both HLA class I and II molecules of DCs, promoting both CD4 and CD8 T cell responses. Optimal vaccine platforms include DNA and RNA vaccines and synthetic long peptides. Antigens of choice include mutant sequences, selected cancer testis antigens, and viral antigens. Drugs or physical treatments can mitigate the immunosuppressive cancer microenvironment and include chemotherapeutics, radiation, indoleamine 2,3-dioxygenase (IDO) inhibitors, inhibitors of T cell checkpoints, agonists of selected TNF receptor family members, and inhibitors of undesirable cytokines. The specificity of therapeutic vaccination combined with such immunomodulation offers an attractive avenue for the development of future cancer therapies.
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Cites
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Elements of cancer immunity and the cancer–immune set point
Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352
CD4+ T cell help in cancer immunology and immunotherapy
Borst, J., Ahrends, T., Bąbała, N., Melief, C. J. M., & Kastenmüller, W. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0044-0 · Cited by 1,585
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Self-citationTowards personalized, tumour-specific, therapeutic vaccines for cancer
Hu, Z., Ott, P. A., & Wu, C. J. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.131 · Cited by 1,067
Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
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Metadata
- Authors
- Melief, C. J. M., van Hall, T., Arens, R., Ossendorp, F., & van der Burg, S. H.
- Venue
- Journal of Clinical Investigation
- Published
- 2015-07-27
- Volume
- 125
- Issue
- 9
- Pages
- 3401-3412
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1938515409
- Cited by
- 1,164
- References
- 55
- FWCI
- 22.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Melief, C. J. M., van Hall, T., Arens, R., Ossendorp, F., & van der Burg, S. H. (2015). Therapeutic cancer vaccines. Journal of Clinical Investigation. https://doi.org/10.1172/jci80009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
