The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Versatile roles of extracellular vesicles in cancer
Open accessAbstract
Numerous studies have shown that non-cell-autonomous regulation of cancer cells is an important aspect of tumorigenesis. Cancer cells need to communicate with stromal cells by humoral factors such as VEGF, FGFs, and Wnt in order to survive. Recently, extracellular vesicles (EVs) have also been shown to be involved in cell-cell communication between cancer cells and the surrounding microenvironment and to be important for the development of cancer. In addition, these EVs contain small noncoding RNAs, including microRNAs (miRNAs), which contribute to the malignancy of cancer cells. Here, we provide an overview of current research on EVs, especially miRNAs in EVs. We also propose strategies to treat cancers by targeting EVs around cancer cells.
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Cites
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Metadata
- Authors
- Kosaka, N., Yoshioka, Y., Fujita, Y., & Ochiya, T.
- Venue
- Journal of Clinical Investigation
- Published
- 2016-03-14
- Volume
- 126
- Issue
- 4
- Pages
- 1163-1172
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2300899067
- Cited by
- 348
- References
- 14
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
