The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair
Open accessAbstract
Osteoblast-derived VEGF is important for bone development and postnatal bone homeostasis. Previous studies have demonstrated that VEGF affects bone repair and regeneration; however, the cellular mechanisms by which it works are not fully understood. In this study, we investigated the functions of osteoblast-derived VEGF in healing of a bone defect. The results indicate that osteoblast-derived VEGF plays critical roles at several stages in the repair process. Using transgenic mice with osteoblast-specific deletion of Vegfa, we demonstrated that VEGF promoted macrophage recruitment and angiogenic responses in the inflammation phase, and optimal levels of VEGF were required for coupling of angiogenesis and osteogenesis in areas where repair occurs by intramembranous ossification. VEGF likely functions as a paracrine factor in this process because deletion of Vegfr2 in osteoblastic lineage cells enhanced osteoblastic maturation and mineralization. Furthermore, osteoblast- and hypertrophic chondrocyte-derived VEGF stimulated recruitment of blood vessels and osteoclasts and promoted cartilage resorption at the repair site during the periosteal endochondral ossification stage. Finally, osteoblast-derived VEGF stimulated osteoclast formation in the final remodeling phase of the repair process. These findings provide a basis for clinical strategies to improve bone regeneration and treat defects in bone healing.
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Cited by
The roles of vascular endothelial growth factor in bone repair and regeneration
Hu, K., & Olsen, B. R. (2016) · Bone · doi:10.1016/j.bone.2016.06.013 · Cited by 678
Self-citationSubchondral bone microenvironment in osteoarthritis and pain
Hu, Y., Chen, X., Wang, S., Jing, Y., & Su, J. (2021) · Bone Research · doi:10.1038/s41413-021-00147-z · Cited by 577
It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration
Grosso, A., Burger, M. G., Lunger, A., Schaefer, D. J., Banfi, A., & Di Maggio, N. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00068 · Cited by 445
The endothelium–bone axis in development, homeostasis and bone and joint disease
Tuckermann, J., & Adams, R. H. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00682-3 · Cited by 258
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Metadata
- Authors
- Hu, K., & Olsen, B. R.
- Venue
- Journal of Clinical Investigation
- Published
- 2016-01-05
- Volume
- 126
- Issue
- 2
- Pages
- 509-526
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2225056950
- Cited by
- 668
- References
- 68
- FWCI
- 20.92
- Type
- journal article
- Language
- en
- Open access
- green
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