Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

Vincenti, Matthew P; Brinckerhoff, Constance E

doi:10.1186/ar401

Cited by 796Protease and Inhibitor MechanismsOsteoarthritis Treatment and MechanismsRheumatoid Arthritis Research and Therapies

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

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Vincenti, Matthew P, Brinckerhoff, Constance E·2002·Arthritis Research & Therapy

DOI 10.1186/ar401PMC PMC128926

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Abstract

Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the progression of rheumatoid arthritis and osteoarthritis. Of these enzymes, the expression of MMP-1 and MMP-13 is substantially increased in response to IL-1 and tumor necrosis factor-alpha, and elevated levels of these collagenases are observed in arthritic tissues. Therefore, cytokine-mediated MMP-1 and MMP-13 gene regulation is an important issue in arthritis research. In this review, we discuss current models of MMP-1 and MMP-13 transcriptional regulation, with a focus on signaling intermediates and transcription factors that may be future targets for the development of new arthritis drugs.

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Expression of MMP-13 is regulated by IL-1β and TNF-α, which promote transcription of MMP-13 gene by activating MAPK and NF-κB signaling pathways.
“The expression of MMP-13 is regulated by IL-1β and TNF-α. These factors promote the transcription of the MMP-13 gene by activating the MAPK and NF-κB signaling pathways.342–344”
From Glucagon-like peptide-1 receptor: mechanisms and advances in therapy (2024) · cites this paper as [342]
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Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766 · see citing works
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246 · see citing works
Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244 · see citing works
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works
NF-κB: a key role in inflammatory diseases
Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11830 · Cited by 3,918 · see citing works
Matrix Metalloproteinases
Nagase, H., & Woessner, J. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21491 · Cited by 3,905 · see citing works
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,432 · see citing works
The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes
Firestein, G. S., & Manning, A. M. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199904)42:4 · Cited by 2,191 · see citing works
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
Kölch, W. (2000) · Biochemical Journal · doi:10.1042/bj3510289 · Cited by 1,443 · see citing works
Organization and regulation of mitogen-activated protein kinase signaling pathways
Garrington, T. P., & Johnson, G. L. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80028-3 · Cited by 1,275 · see citing works
Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element
Diamond, M. I., Miner, J. N., Yoshinaga, S. K., & Yamamoto, K. R. (1990) · Science · doi:10.1126/science.2119054 · Cited by 1,274 · see citing works
The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
Ninomiya‐Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z., & Matsumoto, K. (1999) · Nature · doi:10.1038/18465 · Cited by 1,187 · see citing works
Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.
Ray, A., & Prefontaine, K. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.752 · Cited by 1,064 · see citing works
Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.
Mitchell, P. G., Magna, H. A., Reeves, L. M., Lopresti‐Morrow, L., Yocum, S. A., Rosner, P. J., Geoghegan, K. F., & Hambor, J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118475 · Cited by 943 · see citing works
NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100
Xiao, G., Harhaj, E. W., & Sun, S. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00187-3 · Cited by 836 · see citing works
Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors
Scheinman, R. I., Gualberto, A., Jewell, C. M., Cidlowski, J. A., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.943 · Cited by 819 · see citing works
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
Han, Z., Boyle, D. L., Chang, L., Bennett, B. L., Karin, M., Yang, L., Manning, A. M., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12466 · Cited by 781 · see citing works
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription.
Rutter, J. L., Mitchell, T. I., Butticè, G., et al. (1998) · PubMed · Cited by 533 · see citing works
Retinoic acid is a negative regulator of AP-1-responsive genes.
Schüle, R., Rangarajan, P. N., Yang, N., Kliewer, S. A., Ransone, L. J., Bolado, J., Verma, I. M., & Evans, R. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6092 · Cited by 526 · see citing works
The AP-1 site and MMP gene regulation: What is all the fuss about?
Benbow, U., & Brinckerhoff, C. (1997) · Matrix Biology · doi:10.1016/s0945-053x(97)90026-3 · Cited by 521 · see citing works
Self-citation
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.
Badger, A. M., Bradbeer, J. N., Votta, B. J., Lee, J. C., Adams, J. L., & Griswold, D. E. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21307-6 · Cited by 499 · see citing works
Proteases in invasion: matrix metalloproteinases
Stetler‐Stevenson, W. G., & Yu, A. E. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0365 · Cited by 409 · see citing works
Cbfa1 Is a Positive Regulatory Factor in Chondrocyte Maturation
Enomoto, H., Enomoto‐Iwamoto, M., Iwamoto, M., Nomura, S., Himeno, M., Kitamura, Y., Kishimoto, T., & Komori, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8695 · Cited by 387 · see citing works
Differential regulation of c‐Jun by ERK and JNK during PC12 cell differentiation
Leppä, S., Saffrich, R., Ansorge, W., & Bohmann, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4404 · Cited by 335 · see citing works
Interstitial collagenases as markers of tumor progression.
Brinckerhoff, C., Rutter, J. L., & Benbow, U. (2000) · PubMed · Cited by 333 · see citing works
Self-citation
Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix Metalloproteinases
Borden, P., & Heller, R. A. (1997) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v7.i1-2.90 · Cited by 327 · see citing works
GLUCOCORTICOID AND MINERALOCORTICOID RECEPTORS: Biology and Clinical Relevance
Funder, M. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.231 · Cited by 320 · cited 1× · see citing works
“ments present in the promoters of many genes [52].”
Background
Osteoarthritic Lesions. Involvement of three different collagenases
Shlopov, B. V., Lie, W., Mainardi, C. L., Cole, A. A., Chubinskaya, S., & Hasty, K. A. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780401120 · Cited by 305 · see citing works
Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.
Ziegler‐Heitbrock, H. W. L., Wedel, A., Schraut, W., Ströbel, M., Wendelgaß, P., Sternsdorf, T., Baeuerle, P. A., Haas, J., & Riethmüller, G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32510-3 · Cited by 303 · see citing works
Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels
Ridley, S. H., Sarsfield, S. J., Lee, J. C., Bigg, H. F., Cawston, T. E., TAYLOR, D. J., DeWitt, D. L., & Saklatvala, J. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3165 · Cited by 286 · see citing works
A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.
Suh, N., Wang, Y., Honda, T., Gribble, G. W., Dmitrovsky, E., Hickey, W. F., Maue, R. A., Place, A. E., Porter, D. M., Spinella, M. J., et al. (1999) · PubMed · Cited by 282 · see citing works
Regulating Expression of the Gene for Matrix Metalloproteinase-1 (Collagenase): Mechanisms that Control Enzyme Activity, Transcription, and mRNA Stability
Vincenti, M. P., White, L. A., Schroen, D. J., Benbow, U., & Brinckerhoff, C. (1996) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v6.i4.40 · Cited by 275 · see citing works
Self-citation
Gene Expression (Collagenase, Tissue Inhibitor of Metalloproteinases, Complement, and HLA–DR) in Rheumatoid Arthritis and Osteoarthritis Synovium. Quantitative Analysis and Effect of Intraarticular Corticosteroids
Firestein, G. S., Paine, M. M., & Littman, B. H. (1991) · Arthritis & Rheumatism · doi:10.1002/art.1780340905 · Cited by 257 · see citing works
The Matrix Metalloproteinase (MMP) and Tissue Inhibitor of Metalloproteinase (TIMP) Genes: Transcriptional and Posttranscriptional Regulation, Signal Transduction and Cell-Type-Specific Expression
Vincenti, M. P. (2003) · Humana Press eBooks · doi:10.1385/1-59259-046-2:121 · Cited by 247 · see citing works
Self-citation
Arsenite induces apoptosis in chinese hamster ovary cells by generation of reactive oxygen species
Wang, T., Kuo, C.-F., Jan, K.-Y., & Huang, H. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199611)169:2 · Cited by 240 · see citing works
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts.
Vincenti, M., Coon, C. I., & Brinckerhoff, C. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199811)41:11 · Cited by 239 · see citing works
Self-citation
Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion/deletion polymorphism in its promoter region.
Kanamori, Y., Matsushima, M., Minaguchi, T., Kobayashi, K., Sagae, S., Kudo, R., Terakawa, N., & Nakamura, Y. (1999) · PubMed · Cited by 217 · see citing works
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
Badger, A. M., Griswold, D. E., Kapadia, R. D., Blake, S. M., Swift, B. A., Hoffman, S. J., Stroup, G. B., Webb, E. F., Rieman, D. J., Gowen, M., et al. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 213 · see citing works
Defining therapeutic targets by using adenovirus: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
Bondeson, J., Foxwell, B. M. J., Brennan, F. M., & Feldmann, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5668 · Cited by 207 · see citing works
NF‐κB p105 is a target of IκB kinases and controls signal induction of Bcl‐3–p50 complexes
Heissmeyer, V., Krappmann, D., Wulczyn, F. G., & Scheidereit, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4766 · Cited by 197 · see citing works
AP-1 and Cbfa/Runt Physically Interact and Regulate Parathyroid Hormone-dependent MMP13 Expression in Osteoblasts through a New Osteoblast-specific Element 2/AP-1 Composite Element
Heß, J., Porte, D., Münz, C., & Angel, P. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010601200 · Cited by 188 · see citing works
Cytokine Control of Interstitial Collagenase and Collagenase-3 Gene Expression in Human Chondrocytes
Borden, P., Solymar, D. C., Sucharczuk, A., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23577 · Cited by 178 · see citing works
Activity loss and the onset of depressive symptoms: Do some activities matter more than others?
Katz, P., & Yelin, E. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200105)44:5 · Cited by 175 · see citing works
Pharmacological Effects of SB 220025, a Selective Inhibitor of P38 Mitogen-Activated Protein Kinase, in Angiogenesis and Chronic Inflammatory Disease Models
Jackson, J. R., Bolognese, B. J., Hillegass, L. M., Kassis, S., Adams, J. L., Griswold, D. E., & Winkler, J. D. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37283-0 · Cited by 173 · see citing works
The oncoprotein Bcl‐3 can facilitate NF‐kappa B‐mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.
Franzoso, G., Bours, V., Azarenko, V., Park, S., Tomita-Yamaguchi, M., KANNO, T., Brown, K., & Siebenlist, U. K. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06067.x · Cited by 171 · see citing works
A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-Activated Receptor γ
Wang, Y., Porter, W. W., Suh, N., Honda, T., Gribble, G. W., Leesnitzer, L. M., Plunket, K. D., Mangelsdorf, D. J., Blanchard, S. G., Willson, T. M., et al. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.10.0545 · Cited by 171 · see citing works
Parathyroid Hormone Regulates the Rat Collagenase-3 Promoter in Osteoblastic Cells through the Cooperative Interaction of the Activator Protein-1 Site and the runt Domain Binding Sequence
Selvamurugan, N., Chou, W., Pearman, A. T., Pulumati, M. R., & Partridge, N. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10647 · Cited by 170 · see citing works
Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis
Campbell, I. K., Gerondakis, S., O’Donnell, K., & Wicks, I. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8298 · Cited by 168 · see citing works
Ongoing trials with matrix metalloproteinase inhibitors
Brown, P. D. N. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.9.2167 · Cited by 167 · see citing works
The measurement of collagenase, tissue inhibitor of metalloproteinases (timp), and collagenase—timp complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis
Clark, I. M., Powell, L. K., Ramsey, S., et al. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360313 · Cited by 164 · see citing works
Integration of the NF-κB and mitogen-activated protein kinase/AP-1 pathways at the Collagenase-1 promoter: Divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts
Barchowsky, A., Frleta, D., & Vincenti, M. P. (2000) · Cytokine · doi:10.1006/cyto.2000.0743 · Cited by 158 · see citing works
Self-citation
Jun N-Terminal Kinase in Rheumatoid Arthritis
Han, Z., Boyle, D. L., Aupperle, K. R., Bennett, B. L., Manning, A. M., & Firestein, G. S. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35079-7 · Cited by 157 · see citing works
Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.
Yang‐Yen, H., Xk, Z., Graupner, G., Tzukerman, M., Sakamoto, B., Karin, M., & Pfahl, M. (1991) · PubMed · Cited by 156 · see citing works
Murine Gcm1 gene is expressed in a subset of placental trophoblast cells
Basyuk, E. I., Cross, J. C., Corbin, J., Nakayama, H., Hunter, P., Nait‐Oumesmar, B., & Lazzarini, R. A. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199904)214:4 · Cited by 148 · see citing works
Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormone
Porte, D., Tuckermann, J. P., Becker, M., Baumann, B., Teurich, S., Higgins, T., Owen, M. J., Schorpp‐Kistner, M., & Angel, P. E. (1999) · Oncogene · doi:10.1038/sj.onc.1202333 · Cited by 143 · see citing works
The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.
O’Hagan, R. C., Tozer, R. G., Symons, M. H., McCormick, F. P., & Hassell, J. A. (1996) · PubMed · Cited by 140 · see citing works
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα
Heissmeyer, V., Krappmann, D., Hatada, E. N., & Scheidereit, C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1024-1035.2001 · Cited by 134 · see citing works
The generation of nfkb2 p52: mechanism and efficiency
Heusch, M. I., Li, L., Geleziunas, R., & Greene, W. C. (1999) · Oncogene · doi:10.1038/sj.onc.1203022 · Cited by 111 · see citing works
Mapping of Glucocorticoid Receptor DNA Binding Domain Surfaces Contributing to Transrepression of NF-κB and Induction of Apoptosis
Tao, Y., Williams-Skipp, C., & Scheinman, R. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000526200 · Cited by 96 · see citing works
Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms.
Schroen, D. J., & Brinckerhoff, C. (1996) · Europe PMC (PubMed Central) · Cited by 91 · see citing works
Self-citation
A Single Nucleotide Polymorphism in the Matrix Metalloproteinase‐1 Promoter in Endometrial Carcinomas
Nishioka, Y., Kobayashi, K., Sagae, S., et al. (2000) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2000.tb00989.x · Cited by 90 · see citing works
Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1)
Vincenti, M. P., Coon, C. I., Mengshol, J. A., Yocum, S. A., Mitchell, P. G., & Brinckerhoff, C. (1998) · Biochemical Journal · doi:10.1042/bj3310341 · Cited by 90 · see citing works
Self-citation
SAP1a is a nuclear target of signaling cascades involving ERKs.
Janknecht, R., Ernst, W. H., & Nordheim, A. (1995) · PubMed · Cited by 85 · see citing works
Two activator protein-1 elements in the matrix metalloproteinase-1 promoter have differential effects on transcription and bind Jun D, c-Fos, and Fra-2
White, L. A., & Brinckerhoff, C. (1995) · Matrix Biology · doi:10.1016/s0945-053x(05)80014-9 · Cited by 81 · see citing works
Self-citation
Suppression of collagenase gene expression by all‐trans and 9‐cis retinoic acid is ligand dependent and requires both RARs and RXRs
Pan, L., Eckhoff, C., & Brinckerhoff, C. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240570402 · Cited by 67 · see citing works
Self-citation
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.
Bondeson, J., Brennan, F. M., Foxwell, B. M. J., & Feldmann, M. (2000) · PubMed · Cited by 66 · see citing works
The potential of signal transduction inhibitors for the treatment of arthritis: is it all just JNK?
Vincenti, M. P., & Brinckerhoff, C. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13508 · Cited by 58 · see citing works
Self-citation
Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels
Kuwabara, K., Shudo, K., & Hori, Y. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01440-3 · Cited by 43 · see citing works
Novel phorbol ester response region in the collagenase promoter binds Fos and Jun
Chamberlain, S. H., Hemmer, R. M., & Brinckerhoff, C. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240520310 · Cited by 43 · see citing works
Self-citation
Reply
Romas (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200004)43:4
Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: Viewpoint based on a systemic pathogenetic role
Straub, R. H., & Cutolo, M. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200103)44:3
Untitled work
Atsumi (2000) · doi:10.1002/1529-0131(200009)43:9
Untitled work
Wilson (1999) · doi:10.1002/1529-0131(199907)42:7

Flagged first, then by citations

Research works printed but not linked: 11

[7]7. Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE: Interleukin-1 induction of collagenase 3 (matrix metallo- proteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differen- tial regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000, 43:801-811.
[10]10. Goldring MB: The role of the chondrocyte in osteoarthritis. Arthritis Rheum 2000, 43:1916-1926.
[13]13. Tetlow LC, Adlam DJ, Woolley DE: Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenera- tive changes. Arthritis Rheum 2001, 44:585-594.
[18]18. Westhoff CS, Freudiger D, Petrow P, Seyfert C, Zacher J, Kriegs- mann J, Pap T, Gay S, Stiehl P, Gromnica-Ihle E, Wernicke D: Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis. Arthritis Rheum 1999, 42:1517-1527.
[31]31. Xiao G, Harhaj EW, Sun SC: NF-kappaB-inducing kinase regu- lates the processing of NF-kappaB2 p100. Mol Cell 2001, 7: 401-409.
[32]32. Heissmeyer V, Krappmann D, Hatada EN, Scheidereit C: Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-medi- ated ubiquitination and degradation for the NF-kappaB pre- cursor p105 and IkappaBalpha. Mol Cell Biol 2001, 21: 1024-1035.
[45]45. Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, Sato M, Yamagiwa H, Kimura T, Yasui N, Ochi T, Endo N, Kita- mura Y, Kishimoto T, Komori T: Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn 1999, 214: 279-290.
[58]58. Schroen DJ, Brinckerhoff CE: Inhibition of rabbit collagenase (matrix metalloproteinase-1; MMP-1) transcription by retinoid receptors: evidence for binding of RARs/RXRs to the -77 AP-1 site through interactions with c-Jun. J Cell Physiol 1996, 169: 320-332.
[63]63. Mix KS, Mengshol JA, Benbow U, Vincenti MP, Sporn MB, Brinck- erhoff CE: A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflamma- tory cytokines. Arthritis Rheum 2001, 44:1096-1104.
[66]66. Fahmi H, Di Battista JA, Pelletier JP, Mineau F, Ranger P, Martel- Pelletier J: Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondro- cytes. Arthritis Rheum 2001, 44:595-607.
[71]71. Firestein GS, Manning AM: Signal transduction and transcrip- tion factors in rheumatic disease. Arthritis Rheum 1999, 42: 609-621.

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Wang, T., & He, C. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.10.002 · Cited by 1,034 · see citing works
Glucagon-like peptide-1 receptor: mechanisms and advances in therapy
Zheng, Z., Zong, Y., Ma, Y., Tian, Y., Pang, Y., Zhang, C., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01931-z · Cited by 1,036 · see citing works
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
Coryell, P. R., Diekman, B. O., & Loeser, R. F. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00533-7 · Cited by 761 · see citing works
The regulation of matrix metalloproteinases and their inhibitors
Clark, I. M., Swingler, T. E., Sampieri, C. L., & Edwards, D. R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.12.006 · Cited by 555 · see citing works
Contribution of runt‐related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability
Kamekura, S., Kawasaki, Y., Hoshi, K., Shimoaka, T., Chikuda, H., Maruyama, Z., Komori, T., Sato, S., Takeda, S., Karsenty, G., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22041 · Cited by 319 · see citing works
MMP-1: the elder of the family
Pardo, A., & Selman, M. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.06.017 · Cited by 268 · see citing works
Matrix metalloproteases in aberrant fibrotic tissue remodeling
Pardo, A., & Selman, M. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200601-012tk · Cited by 260 · see citing works
Pathways of matrix metalloproteinase induction in heart failure: Bioactive molecules and transcriptional regulation
DESCHAMPS, A., & SPINALE, F. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.10.004 · Cited by 189 · see citing works
Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials
Jones, J. A., McNally, A. K., Chang, D. T., Qin, L. A., Meyerson, H., Colton, E., Kwon, I. L. K., Matsuda, T., & Anderson, J. M. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31220 · Cited by 121 · see citing works
Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase
Dasgupta, J., Kar, S., Liu, R., Joseph, J., Kalyanaraman, B., Remington, S. J., Chen, C., & Melendez, J. A. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22193 · Cited by 90 · see citing works
Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis
Li, S., Pritchard, D. M., & Yu, L.-G. (2022) · Cancers · doi:10.3390/cancers14133263 · Cited by 82 · see citing works
Tiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts
Lu, J., Guo, J.-H., Tu, X.-L., Zhang, C., Zhao, M., Zhang, Q.-W., & Gao, F.-H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0159998 · Cited by 79 · see citing works
The role of TRPV1 channel in aged human skin
Lee, Y. M., Kang, S. M., & Chung, J. H. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.11.003 · Cited by 73 · see citing works
Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of IκB Kinase through Suppression of Metalloproteinase Expression
Pattoli, M. A., MacMaster, J. F., Gregor, K. R., & Burke, J. R. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087569 · Cited by 56 · see citing works
Harnessing Extracellular Matrix Biology for Tumor Drug Delivery
Subrahmanyam, N., & Ghandehari, H. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11020088 · Cited by 42 · see citing works
The Potential Protective Effects of Calcitonin Involved in Coordinating Chondrocyte Response, Extracellular Matrix, and Subchondral Trabecular Bone in Experimental Osteoarthritis
Cheng, T., Zhang, L., Fu, X., Wang, W., Xu, H., Song, H., & Zhang, Y. (2013) · Connective Tissue Research · doi:10.3109/03008207.2012.760549 · Cited by 32 · see citing works
Protective Effects of Antioxidin-RL from Odorrana Livida Against Ultraviolet B-Irradiated Skin Photoaging
Qin, D., Lee, W.-H., Gao, Z., Zhang, W., Peng, M., Sun, T., & Gao, Y. (2018) · Peptides · doi:10.1016/j.peptides.2018.01.009 · Cited by 27 · see citing works

cAMP Involvement in the Expression of MMP-2 and MT-MMP1 Metalloproteinases in Human Endothelial Cells
FrancescaPeracchia, AntonioTamburro, CesariaProntera, et al. (1997) · Arteriosclerosis Thrombosis and Vascular Biology
cAMP Involvement in the Expression of MMP-2 and MT-MMP1 Metalloproteinases in Human Endothelial Cells
Peracchia, F., Tamburro, A., Prontera, C., et al. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.3185 · Cited by 18 · see citing works
Determination of interstitial collagenase (MMP-1) in patients with rheumatoid arthritis.
Maeda, S., Sawai, T., Uzuki, M., Takahashi, Y., OMOTO, H., Seki, M., & Sakurai, M. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.12.970 · Cited by 73 · see citing works
Method to analyze collagenase and gelatinase activity by fibroblasts in culture
Gould, L. J., Yager, D. R., McGeehan, G. M., & Diegelmann, R. F. (1999) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-999-0004-x · Cited by 1 · see citing works
The measurement of collagenase, tissue inhibitor of metalloproteinases (timp), and collagenase—timp complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis
Clark, I. M., Powell, L. K., Ramsey, S., et al. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360313 · Cited by 164 · see citing works

Authors: Vincenti, M. P., & Brinckerhoff, C. E.
Affiliations: Dartmouth College (US)
Corresponding author: Vincenti, Matthew P
Venue: Arthritis Research & Therapy
Publisher: Springer Science and Business Media LLC
Published: 2002-04
Volume: 4
Issue: 3
Pages: 157-64
ISSN: 1478-6354 (ISSN-L)
1478-6362
DOI: 10.1186/ar401
PMC: PMC128926
OpenAlex: W1554947160
Cited by: 796
References: 73
Citations by year: 2026: 22 · 2025: 38 · 2024: 39 · 2023: 37 · 2022: 36 · 2021: 35 · 2020: 36 · 2019: 41 · 2018: 49 · 2017: 37 · 2016: 40 · 2015: 30 · 2014: 46 · 2013: 35 · 2012: 28
FWCI: 1.50
Type: journal article
Language: en
Open access: gold
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Arthritis Research & Therapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Defense
RGK Foundation
National Institutes of Health (5k01ar002024-05)
National Cancer Institute (R01CA077267, CA77267)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 26599, AR 46977, R37AR026599, R01AR046977, AR02024, R01AR026599)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: collagenase, MMP-1, MMP-13, MMP-8, transcriptional regulation, rheumatoid arthritis, osteoarthritis, type II collagen degradation, cartilage, interleukin-1, TNF-α, cytokine signaling, transcription factors
MeSH terms: Animals, Arthritis, Rheumatoid, Humans, Osteoarthritis, Transcription Factors, Signal Transduction, Gene Expression Regulation, Enzymologic, NF-kappa B, Collagenases, Matrix Metalloproteinase 1, Mitogen-Activated Protein Kinase Kinases, Matrix Metalloproteinase 13

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Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors

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