The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
Open accessAbstract
Decorin, a small leucine-rich proteoglycan, is capable of suppressing the growth of various tumor cell lines when expressed ectopically. In this report, we investigated the biochemical mechanism by which decorin inhibits cell cycle progression. In A431 squamous carcinoma cells, decorin proteoglycan or protein core induced a marked growth suppression, when either exogenously added or endogenously produced by a transgene. Decorin caused rapid phosphorylation of the EGF receptor and a concurrent activation of mitogen-activated protein (MAP) kinase signal pathway. This led to a protracted induction of endogenous p21, a potent inhibitor of cyclin-dependent kinases, and ultimate cell cycle arrest. Biglycan, a related proteoglycan, had no effect. Moreover, decorin activated the EGF receptor/MAP kinase/ p21 axis in cell lines of various histogenetic backgrounds. These results provide the first evidence that EGF and decorin converge functionally to regulate the cell cycle through activation of a common pathway which ultimately leads to growth suppression.
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Calcium's Role in Mechanotransduction during Muscle Development
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
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Negative regulation of transforming growth factor-β by the proteoglycan decorin
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Self-citationRole of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
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Targeted Disruption of Decorin Leads to Abnormal Collagen Fibril Morphology and Skin Fragility
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Self-citationBiological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction
Schaefer, L., & Iozzo, R. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800020200 · Cited by 549
Self-citationProteoglycans of the extracellular matrix and growth control
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Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics
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Metadata
- Authors
- Moscatello, D. K., Santra, M., Mann, D. M., McQuillan, D. J., Wong, A. J., & Iozzo, R. V.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-01-15
- Volume
- 101
- Issue
- 2
- Pages
- 406-412
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2023104790
- Cited by
- 272
- References
- 42
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Moscatello, D. K., Santra, M., Mann, D. M., McQuillan, D. J., Wong, A. J., & Iozzo, R. V. (1998). Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor. Journal of Clinical Investigation. https://doi.org/10.1172/jci846
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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