The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
Open accessAbstract
BACKGROUND: Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS: A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen consortium). The analysis included 16 traits of left ventricular (LV) structure, and systolic and diastolic function. RESULTS: The discovery analysis included 21 cohorts for structural and systolic function traits (n = 32,212) and 17 cohorts for diastolic function traits (n = 21,852). Replication was performed in 5 cohorts (n = 14,321) and 6 cohorts (n = 16,308), respectively. Besides 5 previously reported loci, the combined meta-analysis identified 10 additional genome-wide significant SNPs: rs12541595 near MTSS1 and rs10774625 in ATXN2 for LV end-diastolic internal dimension; rs806322 near KCNRG, rs4765663 in CACNA1C, rs6702619 near PALMD, rs7127129 in TMEM16A, rs11207426 near FGGY, rs17608766 in GOSR2, and rs17696696 in CFDP1 for aortic root diameter; and rs12440869 in IQCH for Doppler transmitral A-wave peak velocity. Findings were in part validated in other cohorts and in GWAS of related disease traits. The genetic loci showed associations with putative signaling pathways, and with gene expression in whole blood, monocytes, and myocardial tissue. CONCLUSION: The additional genetic loci identified in this large meta-analysis of cardiac structure and function provide insights into the underlying genetic architecture of cardiac structure and warrant follow-up in future functional studies. FUNDING: For detailed information per study, see Acknowledgments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In addition to CAVS, a GWA study also found at a genome-wide significance level an association between rs6702619 and aortic root diameter (Wild et al., 2017).”
From Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis (2021) · cites this paper as Wild et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, B. K., Loh, P.-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., & Neale, B. M. (2015) · Nature Genetics · doi:10.1038/ng.3211 · Cited by 5,559
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205
Recommendations for chamber quantification☆
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J. B., & Shanewise, J. S. (2006) · European Journal of Echocardiography · doi:10.1016/j.euje.2005.12.014 · Cited by 3,588
Burden of Systolic and Diastolic Ventricular Dysfunction in the Community
Redfield, M. M., Jacobsen, S. J., Burnett, J. C. J., Mahoney, D. W., Bailey, K. R., & Rodeheffer, R. J. (2003) · JAMA · doi:10.1001/jama.289.2.194 · Cited by 2,989
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
the CARDIoGRAMplusC4D Consortium (2015) · Nature Genetics · doi:10.1038/ng.3396 · Cited by 2,447
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
The International Consortium for Blood Pressure Genome-Wide Association Studies (2011) · Nature · doi:10.1038/nature10405 · Cited by 2,033
Self-citationRegulation of cardiac hypertrophy by intracellular signalling pathways
Heineke, J., & Molkentin, J. D. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1983 · Cited by 1,890
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics, Schunkert, H., the CARDIoGRAM Consortium, König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F. R., et al. (2011) · Nature Genetics · doi:10.1038/ng.784 · Cited by 1,866
Self-citation
Cited by
Sorted by citations
Shah, S. H., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13690-5 · Cited by 836
Self-citationNitric oxide signalling in cardiovascular health and disease
Farah, C., Michel, L. Y. M., & Balligand, J.-L. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.224 · Cited by 779
Objectives, design and main findings until 2020 from the Rotterdam Study
Ikram, M. A., Brusselle, G., Ghanbari, M., Goedegebure, A., Ikram, M. K., Kavousi, M., Kieboom, B. C. T., Klaver, C. C. W., de Knegt, R. J., Luik, A. I., et al. (2020) · European Journal of Epidemiology · doi:10.1007/s10654-020-00640-5 · Cited by 463
Self-citationGoette, A., Corradi, D., Dobrev, D., Aguinaga, L., Cabrera, J. Á., Chugh, S. S., de Groot, J. R., Soulat-Dufour, L., Fenelon, G., Hatem, S. N., et al. (2024) · EP Europace · doi:10.1093/europace/euae204 · Cited by 370
Pirruccello, J. P., Bick, A., Wang, M., Chaffin, M., Friedman, S., Yao, J., Guo, X., Venkatesh, B. A., Taylor, K. D., Post, W. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15823-7 · Cited by 267
Self-citationDuffy, G., Cheng, P. P., Yuan, N., He, B. D., Kwan, A. C., Shun-Shin, M. J., Alexander, K. M., Ebinger, J. E., Lungren, M. P., Rader, F., et al. (2022) · JAMA Cardiology · doi:10.1001/jamacardio.2021.6059 · Cited by 252
Self-citationAung, N., Vargas, J. D., Yang, C., Cabrera, C., Warren, H. R., Fung, K., Tzanis, E. L., Barnes, M. R., Rotter, J. I., Taylor, K. D., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.041161 · Cited by 203
Self-citationCohort Profile Update: The Study of Health in Pomerania (SHIP)
Völzke, H., Schössow, J., Schmidt, C. O., Jürgens, C., Richter, A., Werner, A., Werner, N., Radke, D., Teumer, A., Ittermann, T., et al. (2022) · International Journal of Epidemiology · doi:10.1093/ije/dyac034 · Cited by 226
Self-citationDeep learning enables genetic analysis of the human thoracic aorta
Pirruccello, J. P., Chaffin, M. D., Chou, E. L., Fleming, S. J., Lin, H., Nekoui, M., Khurshid, S., Friedman, S. F., Bick, A. G., Arduini, A., et al. (2022) · Nature Genetics · doi:10.1038/s41588-021-00962-4 · Cited by 210
Self-citationPhenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery
Aragam, K. G., Chaffin, M. D., Levinson, R. T., McDermott, G. C., Choi, S. H., Shoemaker, M. B., Haas, M. E., Weng, L.-C. C., Lindsay, M. E., Smith, J. G., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035774 · Cited by 156
Self-citationGenetic and functional insights into the fractal structure of the heart
Meyer, H. V., Dawes, T. J. W., Serrani, M., Bai, W., Tokarczuk, P. F., Cai, J., de Marvao, A., Henry, A., Lumbers, R. T., Gierten, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2635-8 · Cited by 139
Thériault, S., Gaudreault, N., Lamontagne, M., Rosa, M., Boulanger, M.-C., Messika-Zeitoun, D., Clavel, M.-A., Capoulade, R., Dagenais, F., Pibarot, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03260-6 · Cited by 135
Genome-wide analysis yields new loci associating with aortic valve stenosis
Helgadottir, A., Thorleifsson, G., Gretarsdottir, S., Stefansson, O. A., Tragante, V., Thorolfsdottir, R. B., Jonsdottir, I., Bjornsson, T., Steinthorsdottir, V., Verweij, N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03252-6 · Cited by 125
Self-citationArmstrong, N. J., Mather, K. A., Sargurupremraj, M., Knol, M. J., Malik, R., Satizábal, C. L., Yanek, L. R., Wen, W. X., Gudnason, V. G., Dueker, N., et al. (2020) · Stroke · doi:10.1161/strokeaha.119.027544 · Cited by 117
Self-citationConvergence of coronary artery disease genes onto endothelial cell programs
Schnitzler, G. R., Kang, H. Y., Fang, S., Angom, R. S., Lee-Kim, V. S., Ma, X. R., Zhou, R., Zeng, T., Guo, K., Taylor, M. S., et al. (2024) · Nature · doi:10.1038/s41586-024-07022-x · Cited by 108
Genetic analysis of right heart structure and function in 40,000 people
Pirruccello, J. P., Achille, P. D., Nauffal, V., Nekoui, M., Friedman, S. F., Klarqvist, M. D. R., Chaffin, M. D., Weng, L.-C. C., Cunningham, J. W., Khurshid, S. S., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01090-3 · Cited by 101
Self-citationThe Athlete’s Heart—Challenges and Controversies
Gerche, A. L., Wasfy, M. M., Brosnan, M. J., Claessen, G., Fatkin, D., Heidbüchel, H., Baggish, A. L., & Kovacic, J. C. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.07.014 · Cited by 114
Epigenomes of Human Hearts Reveal New Genetic Variants Relevant for Cardiac Disease and Phenotype
Tan, W. L. W., Anene-Nzelu, C. G., Wong, E., Lee, C. J. M., Tan, H. S., Tang, S. J., Perrin, A., Wu, K. X., Zheng, W., Ashburn, R. J., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317254 · Cited by 93
Self-citationAndersson, C., Nayor, M. G., Tsao, C. W., Levy, D. A., & Vasan, R. S. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.059 · Cited by 107
Self-citationMcGivney, B. A., Han, H., Corduff, L. R., Katz, L. M., Tozaki, T., MacHugh, D. E., & Hill, E. W. (2020) · Scientific Reports · doi:10.1038/s41598-019-57389-5 · Cited by 90
Towards precision medicine in heart failure
Weldy, C. S., & Ashley, E. A. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00566-9 · Cited by 81
Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure
Arvanitis, M., Tampakakis, E., Zhang, Y., Wang, W., Auton, A., Agee, M., Aslibekyan, S. W., Bell, R. K., Bryc, K., Clark, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14843-7 · Cited by 76
Genetics and mechanisms of thoracic aortic disease
Chou, E. L., Pirruccello, J. P., Ellinor, P. T., & Lindsay, M. E. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00763-0 · Cited by 71
Tcheandjieu, C., Xiao, K., Tejeda, H., Lynch, J. A., Ruotsalainen, S., Bellomo, T. R., Palnati, M., Judy, R., Klarin, D. M., Kember, R. L., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01070-7 · Cited by 60
Aung, N., Vargas, J. D., Yang, C., Fung, K., Sanghvi, M. M., Piechnik, S. K., Neubauer, S., Manichaikul, A. W., Rotter, J. I., Taylor, K. D., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01083-2 · Cited by 60
Self-citationElectronic health records: the next wave of complex disease genetics
Wolford, B. N., Willer, C. J., & Surakka, I. L. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy081 · Cited by 56
Genetic and environmental determinants of diastolic heart function
Thanaj, M., Mielke, J., McGurk, K. A., Bai, W., Savioli, N., de Marvao, A., Meyer, H. V., Zeng, L., Sohler, F., Lumbers, R. T., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00048-2 · Cited by 53
Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension
Song, L., Chen, X., Swanson, T. A., LaViolette, B., Pang, J., Cunio, T., Nagle, M. W., Asano, S. M., Hales, K. J., Shipstone, A., et al. (2020) · eLife · doi:10.7554/elife.58376 · Cited by 60
When genetic burden reaches threshold
Walsh, R., Tadros, R., & Bezzina, C. R. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa269 · Cited by 54
Nayor, M. G., Short, M. I., Rasheed, H., Lin, H., Jonasson, C., Yang, Q., Hveem, K., Felix, J. F., Morrison, A. C., Wild, P. S., et al. (2020) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006749 · Cited by 52
Self-citationThe genetics of human performance
Kim, D. S., Wheeler, M. T., & Ashley, E. A. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00400-5 · Cited by 53
TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension
Page, H. R. A., Dalsgaard, T., Baldwin, S. N., Jepps, T. A., Povstyan, O. V., Olesen, S., & Greenwood, I. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14598 · Cited by 50
Deep learning of left atrial structure and function provides link to atrial fibrillation risk
Pirruccello, J. P., Achille, P. D., Choi, S. H., Rämö, J. T., Khurshid, S. S., Nekoui, M., Jurgens, S. J., Nauffal, V., Kany, S., FinnGen, et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48229-w · Cited by 52
Contemporary and Future Approaches to Precision Medicine in Inherited Cardiomyopathies
Fatkin, D., Calkins, H. G., Elliot, P. M., James, C. A., Peters, S. A., & Kovacic, J. C. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.12.072 · Cited by 51
Khurshid, S. S., Lazarte, J., Pirruccello, J. P., Weng, L.-C. C., Choi, S. H., Hall, A. W., Wang, X., Friedman, S. F., Nauffal, V., Biddinger, K. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37173-w · Cited by 43
Update on Chronic Kidney Disease Mineral and Bone Disorder in Cardiovascular Disease
Lunyera, J., & Scialla, J. J. (2018) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2018.08.001 · Cited by 43
Three-dimensional cardiovascular imaging-genetics: a mass univariate framework
Biffi, C., de Marvao, A., Attard, M., Dawes, T. J. W., Whiffin, N., Bai, W., Shi, W., Francis, C., Meyer, H. V., Buchan, R. J., et al. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx552 · Cited by 37
Tereshchenko, L. G., Sotoodehnia, N., Sitlani, C. M., Ashar, F. N., Kabir, M., Biggs, M. L., Morley, M. P., Waks, J. W., Soliman, E. Z., Buxton, A. E., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008160 · Cited by 34
Self-citationCórdova‐Palomera, A., Tcheandjieu, C., Fries, J., Varma, P., Chen, V. S., Fiterau, M., Xiao, K., Tejeda, H., Keavney, B. D., Cordell, H. J., et al. (2020) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.120.003014 · Cited by 28
Nezhad, F. Y., Verbrugge, S. A. J., Schönfelder, M., Becker, L., de Angelis, M. H., & Wackerhage, H. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00262 · Cited by 30
Molecular Epidemiology of Heart Failure
Smith, J. G. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.07.010 · Cited by 30
Self-citationShorter, J. R., Huang, W., Beak, J. Y., Hua, K., Gatti, D. M., de Villena, F. P., Pomp, D., & Jensen, B. C. (2017) · Mammalian Genome · doi:10.1007/s00335-017-9730-7 · Cited by 28
Cardioprotective Effects of MTSS1 Enhancer Variants
Morley, M. P., Wang, X., Hu, R., Brandimarto, J., Tucker, N. R., Felix, J. F., Smith, N. L., van der Harst, P., Ellinor, P. T., Margulies, K. B., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.037939 · Cited by 25
Self-citationGenetics of canine myxomatous mitral valve disease
O’Brien, M. J., Beijerink, N., & Wade, C. M. (2021) · Animal Genetics · doi:10.1111/age.13082 · Cited by 29
Nekoui, M., Pirruccello, J. P., Achille, P. D., Choi, S. H., Friedman, S. F., Nauffal, V., Ng, K., Batra, P., Ho, J. E., Philippakis, A., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.05.024 · Cited by 25
Atrial Cardiomyopathy in Atrial Fibrillation: A Multimodal Diagnostic Framework
Karakasis, P., Vlachakis, P. K., Theofilis, P., Ktenopoulos, N., Patoulias, D., Fyntanidou, B., Antoniadis, A. P., & Fragakis, N. (2025) · Diagnostics · doi:10.3390/diagnostics15101207 · Cited by 32
Genome-wide studies of heart failure and endophenotypes: lessons learned and future directions
van der Ende, M. Y., Said, M. A., van Veldhuisen, D. J., Verweij, N., & van der Harst, P. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy083 · Cited by 24
Heart-specific DNA methylation analysis in plasma for the investigation of myocardial damage
Ren, J., Jiang, L., Liu, X., Liao, Y., Zhao, X., Tang, F., Yu, H., Shao, Y., Wang, J., Wen, L., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03234-9 · Cited by 23
Aung, N., Lopes, L. R., van Duijvenboden, S., Harper, A. R., Goel, A., Grace, C., Ho, C. Y., Weintraub, W. S., Kramer, C. M., Neubauer, S., et al. (2023) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.122.003716 · Cited by 23
Big Data Approaches in Heart Failure Research
Lanzer, J. D., Leuschner, F., Kramann, R., Levinson, R. T., & Sáez-Rodríguez, J. (2020) · Current Heart Failure Reports · doi:10.1007/s11897-020-00469-9 · Cited by 23
Schaschl, H., Göllner, T., & Morris, D. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-08588-0 · Cited by 21
Chignon, A., Rosa, M., Boulanger, M.-C., Argaud, D., Devillers, R., Bon-Baret, V., Mkannez, G., Li, Z., Rufiange, A., Gaudreault, N., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102241 · Cited by 18
Biomarkers in HFpEF for Diagnosis, Prognosis, and Biological Phenotyping
Eltelbany, M., Shah, P. M., & deFilippi, C. R. (2022) · Current Heart Failure Reports · doi:10.1007/s11897-022-00578-7 · Cited by 22
Yang, Q., Yang, Q., Wu, X., Zheng, R., Lin, H., Wang, S., Joseph, J., Sun, Y. V., Li, M., Wang, T., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101382 · Cited by 18
Self-citationDilated Cardiomyopathy: A Genetic Journey from Past to Future
Newman, N. A., & Burke, M. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111460 · Cited by 20
The polygenic architecture of left ventricular mass mirrors the clinical epidemiology
Mosley, J. D., Levinson, R. T., Farber‐Eger, E. H., Edwards, T. L., Hellwege, J. N., Hung, A. M., Giri, A., Shuey, M. M., Shaffer, C. M., Shi, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64525-z · Cited by 18
Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci
Kyryachenko, S., Georges, A. B., Yu, M., Berrandou, T.-E., Guo, L., Bruneval, P., Rubio, T., Gronwald, J., Baraki, H., Kutschka, I., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.317581 · Cited by 18
Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis
Wang, J., Huertas‐Vázquez, A., Wang, Y., & Lusis, A. J. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00100 · Cited by 17
Asselmann, E., Hertel, J., Schmidt, C. O., Homuth, G., Nauck, M. A., Beesdo‐Baum, K., Grabe, H. J., & Pané‐Farré, C. A. (2018) · Depression and Anxiety · doi:10.1002/da.22812 · Cited by 17
Genetics of atrial cardiomyopathy
Fatkin, D., Huttner, I. G., & Johnson, R. (2019) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000610 · Cited by 19
Imaging Endophenotypes of Stroke as a Target for Genetic Studies
Jian, X., & Fornage, M. (2018) · Stroke · doi:10.1161/strokeaha.117.017073 · Cited by 16
Self-citationAsselmann, E., Hertel, J., Beesdo‐Baum, K., Schmidt, C. O., Homuth, G., Nauck, M. A., Grabe, H. J., & Pané‐Farré, C. A. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.02.060 · Cited by 15
Zhou, Y., Qiu, J., Liu, S., Wang, P., Ma, D., Zhang, G., Cao, Y., Hu, L., Wang, Z., Wu, J., et al. (2022) · Cancer Medicine · doi:10.1002/cam4.4919 · Cited by 15
Ma, X. R., Conley, S. D., Chen, M. S., Kosicki, M., Lu, Y., Bredikhin, D., Cui, R., Sheth, M. U., Qiu, W., Amgalan, D., et al. (2024) · medRxiv · doi:10.1101/2024.11.20.24317557 · Cited by 18
Self-citationWomen-specific risk factors for heart failure: A genetic approach
van der Kemp, J., van der Schouw, Y. T., Asselbergs, F. W., & Onland‐Moret, N. C. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.12.016 · Cited by 14
Christen, T., de Mutsert, R., Lamb, H. J., van Dijk, K. W., le Cessie, S., Rosendaal, F. R., Jukema, J. W., & Trompet, S. (2021) · Peptides · doi:10.1016/j.peptides.2021.170664 · Cited by 14
Panova‐Noeva, M., Eggebrecht, L., Prochaska, J. H., & Wild, P. S. (2019) · Hämostaseologie · doi:10.1055/s-0038-1677520 · Cited by 12
Self-citationUsing Genomics to Identify Novel Therapeutic Targets for Aortic Disease
Raghavan, A., Pirruccello, J. P., Ellinor, P. T., & Lindsay, M. E. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.318771 · Cited by 13
Bianchi, V., Geeven, G., Tucker, N. R., Hilvering, C. R. E., Hall, A. W., Roselli, C., Hill, M. C., Martin, J. F., Margulies, K. B., Ellinor, P. T., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3416642 · Cited by 10
Statkiewicz, M., Maryan, N., Kulecka, M., Kuklinska, U., Ostrowski, J., & Mikuła, M. (2019) · Acta Biochimica Polonica · doi:10.18388/abp.2019_2775 · Cited by 10
Kany, S., Rämö, J. T., Hou, C. R., Jurgens, S. J., Khurshid, S. S., Nauffal, V., Cunningham, J. W., Lau, E. S., Koyama, S., FinnGen, et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02397-7 · Cited by 11
PALMD as a novel target for calcific aortic valve stenosis
Bossé, Y., Mathieu, P., & Thériault, S. (2019) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000605 · Cited by 9
Region-based interaction detection in genome-wide case-control studies
Zhang, S., Jiang, W., Ronald, C. W., & Yu, W. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0583-7 · Cited by 9
Scientific Contributions of Population-Based Studies to Cardiovascular Epidemiology in the GWAS Era
Lieb, W., & Vasan, R. S. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00057 · Cited by 8
Self-citationSáez, M. E., González‐Pérez, A., Hernández‐Olasagarre, B., Beà, A., Moreno–Grau, S., de Rojas, I., Monté, G. C., Orellana, A., Valero, S., Comella, J. X., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52724-2 · Cited by 8
Shah, S. H., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/682013 · Cited by 8
Self-citationIdentification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size
Agrawal, V., Manouchehri, A., Vaitinadin, N. S., Shi, M., Bagheri, M., Gupta, D. K., Kullo, I. J., Luo, Y., McNally, E. M., Puckelwartz, M. J., et al. (2023) · Circulation Heart Failure · doi:10.1161/circheartfailure.123.010557 · Cited by 7
Familial clustering of hypertensive target organ damage in the community
Niiranen, T., Lin, H., Larson, M. G., & Vasan, R. S. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001679 · Cited by 7
Self-citationLow Level of PALMD Contributes to the Metastasis of Uveal Melanoma
Cai, M., Xu, Y., Rong, H., & Yang, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.802941 · Cited by 7
Nayor, M. G., Shen, L., Hunninghake, G. M., Kochunov, P., Barr, R. G., Bluemke, D. A., Broeckel, U., Caravan, P. D., Cheng, S. C., de Vries, P. S., et al. (2021) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.121.012943 · Cited by 5
Self-citationCfdp1 Is Essential for Cardiac Development and Function
Giardoglou, P., Deloukas, P., Dedoussis, G. V., & Beis, D. (2023) · Cells · doi:10.3390/cells12151994 · Cited by 6
Ayele, F. T., Lee, A. J., Workalemahu, T., Zhang, W., Shrestha, D., Amare, A. T., & Ouidir, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-40834-w · Cited by 6
Cardiac lymphatic dysfunction and repair in cardiovascular disease
Bråkenhielm, E. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01271-1 · Cited by 6
Du, Y., Guan, Y., Shao, Z., Jiang, M., Qu, M., Kong, Y., Hong-ji, W., Luo, D., Peng, S., Li, S., et al. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf039 · Cited by 5
Deconstructing the GWAS library: next-generation GWAS
Zhang, W., Koslowski, S., Benzaki, M., Lee, C. J. M., Zhu, Y., Mak, M. C. E., Zhu, Y., Loong, S. S. E., Lettre, G., Anene-Nzelu, C. G., et al. (2025) · Physiological Reviews · doi:10.1152/physrev.00025.2024 · Cited by 5
Li, L., Baxter, S. S., Zhao, P., Gu, N., & Zhan, X. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006071 · Cited by 5
Genome-wide association for heart failure: from discovery to clinical use
Fullenkamp, D. E., Puckelwartz, M. J., & McNally, E. M. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab172 · Cited by 5
Abu-sheikha, A., Johnson, C. S. C., Snyder‐Mackler, N., Zimmerman, K. D., Negrey, J. D., Chiou, K. L., Frye, B. M., Howard, T. D., Shively, C. A., & Register, T. C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1564741 · Cited by 4
Popp, J. L., Patel, K., Cuomo, D., Lynch, R., Leung, S., Berridge, B. R., Rusyn, I., Chiu, W. A., & Threadgill, D. W. (2025) · BMC Cardiovascular Disorders · doi:10.1186/s12872-025-05156-y · Cited by 4
Zhang, J., Yang, Z., Zhang, C.-C., Gao, S., Liu, Y., Li, Y., He, S., Yao, J., Du, J., You, B., et al. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00217.2024 · Cited by 4
Vaitinadin, N. S., Shi, M., Shaffer, C. M., Farber‐Eger, E. H., Lowery, B. D., Agrawal, V., Gupta, D. K., Roden, D. M., Wells, Q. S., & Mosley, J. D. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.025578 · Cited by 5
Ataxina-2, nuevo blanco en enfermedades genéticas complejas
Ramirez-Garcia, S. A., Sánchez‐Corona, J., Ortega-Pacheco, D., Ramírez-Bohórquez, E., & García‐Cruz, D. (2018) · Gaceta Médica de México · doi:10.24875/gmm.18003473 · Cited by 4
Discovering patterns of pleiotropy in genome-wide association studiesPreprint
Zhana, J., CHARGE ECG Working Group, van Setten, J., Brody, J. A., Swenson, B. R., Butler, A. M., Campbell, H., Fabiola Del Greco, M., Evans, D. S., Gibson, Q., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/273540 · Cited by 4
Self-citationSexual, vertical and household transmission of hepatitis C.
Caldwell, S. H., Dickson, R. C., Driscoll, C., & Sue, M. (1995) · PubMed · Cited by 3
Pirruccello, J. P., Bick, A. G., Wang, M., Chaffin, M. D., Lubitz, S. A., Ellinor, P. T., Khera, A. V., Kathiresan, S., & Aragam, K. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.12.946038 · Cited by 3
Zhao, B., Li, T., Fan, Z., Yang, Y., Wang, X., Luo, T., Tang, J., Xiong, D., Wu, Z., Chen, J., et al. (2021) · medRxiv · doi:10.1101/2021.11.01.21265779 · Cited by 3
Han, Y. Y., Hong, Y., Gao, Y., Lu, J., Chen, B., Zhang, L., Yan, X., Sun, Y. J., Zhang, L., Liu, J., et al. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011897 · Cited by 3
Genetic Landscape of Dilated Cardiomyopathy
Николаевна, К. А., Sleptcov, A. A., & Nazarenko, M. S. (2022) · Russian Journal of Genetics · doi:10.1134/s1022795422030085 · Cited by 2
UltraSeP: Sequence-aware pre-training for echocardiography probe movement guidance
Jiang, H., Wang, T., Sun, Z., Wang, Y., Yang, Y., Sun, Y., Jia, N., Li, M., Luo, S., Song, S., et al. (2025) · Pattern Recognition · doi:10.1016/j.patcog.2025.112600 · Cited by 2
The Genetic Determinants of Aortic DistensionPreprint
Pirruccello, J. P., Choi, S. H., Chaffin, M. D., Nekoui, M., Chou, E. L., Jurgens, S. J., Friedman, S. F., Juric, D., Stone, J. R., Batra, P., et al. (2021) · medRxiv · doi:10.1101/2021.10.16.21265089 · Cited by 2
Metadata
- Authors
- Wild, P. S., Felix, J. F., Schillert, A., Teumer, A., Chen, M.-H., Leening, M. J. G., Völker, U., Großmann, V., Brody, J. A., Irvin, M. R., Shah, S. J., Pramana, S., Lieb, W., Schmidt, R., Stanton, A. V., Malzahn, D., Smith, A. V., Sundström, J., Minelli, C., Ruggiero, D., Lyytikäinen, L.-P., Tiller, D., Smith, J. G., Monnereau, C., Di Tullio, M. R., Musani, S. K., Morrison, A. C., Pers, T. H., Morley, M., Kleber, M. E., Aragam, J., Benjamin, E. J., Bis, J. C., Bisping, E., Broeckel, U., Cheng, S., Deckers, J. W., Del Greco M, F., Edelmann, F., Fornage, M., Franke, L., Friedrich, N., Harris, T. B., Hofer, E., Hofman, A., Huang, J., Hughes, A. D., Kähönen, M., investigators, K., Kruppa, J., Lackner, K. J., Lannfelt, L., Laskowski, R., Launer, L. J., Leosdottir, M., Lin, H., Lindgren, C. M., Loley, C., MacRae, C. A., Mascalzoni, D., Mayet, J., Medenwald, D., Morris, A. P., Müller, C., Müller-Nurasyid, M., Nappo, S., Nilsson, P. M., Nuding, S., Nutile, T., Peters, A., Pfeufer, A., Pietzner, D., Pramstaller, P. P., Raitakari, O. T., Rice, K. M., Rivadeneira, F., Rotter, J. I., Ruohonen, S. T., Sacco, R. L., Samdarshi, T. E., Schmidt, H., Sharp, A. S. P., Shields, D. C., Sorice, R., Sotoodehnia, N., Stricker, B. H., Surendran, P., Thom, S., Töglhofer, A. M., Uitterlinden, A. G., Wachter, R., Völzke, H., Ziegler, A., Münzel, T., März, W., Cappola, T. P., Hirschhorn, J. N., Mitchell, G. F., Smith, N. L., Fox, E. R., Dueker, N. D., Jaddoe, V. W. V., Melander, O., Russ, M., Lehtimäki, T., Ciullo, M., Hicks, A. A., Lind, L., Gudnason, V., Pieske, B., Barron, A. J., Zweiker, R., Schunkert, H., Ingelsson, E., Liu, K., Arnett, D. K., Psaty, B. M., Blankenberg, S., Larson, M. G., Felix, S. B., Franco, O. H., Zeller, T., Vasan, R. S., & Dörr, M.
- Affiliations
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Erasmus MC (NL)
- German Centre for Cardiovascular Research (DE)
- Universitätsmedizin Greifswald (DE)
- Boston University (US)
- University of Washington (US)
- University of Alabama at Birmingham (US)
- Northwestern University (US)
- Karolinska Institutet (SE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Medical University of Graz (AT)
- Royal College of Surgeons in Ireland (IE)
- Universitätsmedizin Göttingen (DE)
- University of Iceland (IS)
- Uppsala University (SE)
- Imperial College London (GB)
- Institute of Genetics and Biophysics (IT)
- Tampere University (FI)
- Martin Luther University Halle-Wittenberg (DE)
- Broad Institute (US)
- University of Veterinary Medicine Hannover, Foundation (DE)
- National Institutes of Health (US)
- Hammersmith Hospital (GB)
- Centre for Human Genetics (GB)
- Universität Hamburg (DE)
- Lund University (SE)
- University of Turku (FI)
- The Lundquist Institute (US)
- Beaumont Hospital (IE)
- ORCID
- Wild, Philipp S.
- Felix, Janine F.
- Schillert, Arne
- Teumer, Alexander
- Chen, Ming-Huei
- Leening, Maarten J.G.
- Völker, Uwe
- Brody, Jennifer A.
- Irvin, Marguerite R.
- Shah, Sanjiv J.
- Pramana, Setia
- Lieb, Wolfgang
- Schmidt, Reinhold
- Stanton, Alice V.
- Smith, Albert Vernon
- Sundström, Johan
- Minelli, Cosetta
- Ruggiero, Daniela
- Lyytikäinen, Leo-Pekka
- Monnereau, Claire
- Morrison, Alanna C.
- Pers, Tune H.
- Morley, Michael
- Kleber, Marcus E.
- Benjamin, Emelia J.
- Bis, Joshua C.
- Bisping, Egbert
- Broeckel, Ulrich
- Cheng, Susan
- Deckers, Jaap W.
- Edelmann, Frank
- Fornage, Myriam
- Franke, Lude
- Harris, Tamara B.
- Hofer, Edith
- Huang, Jie
- Hughes, Alun D.
- Kähönen, Mika
- Kruppa, Jochen
- Lackner, Karl J.
- Launer, Lenore J.
- Leosdottir, Margrét
- Lin, Honghuang
- Lindgren, Cecilia M.
- MacRae, Calum A.
- Mascalzoni, Deborah
- Mayet, Jamil
- Medenwald, Daniel
- Morris, Andrew P.
- Müller, Christian
- Nappo, Stefania
- Nilsson, Peter M.
- Nuding, Sebastian
- Nutile, Teresa
- Peters, Annette
- Pramstaller, Peter P.
- Raitakari, Olli T.
- Rice, Kenneth M.
- Rivadeneira, Fernando
- Rotter, Jerome I.
- Ruohonen, Saku T.
- Sacco, Ralph L.
- Schmidt, Helena
- Sharp, Andrew S.P.
- Stricker, Bruno H.
- Surendran, Praveen
- Thom, Simon
- Uitterlinden, André G.
- Wachter, Rolf
- Völzke, Henry
- Ziegler, Andreas
- Münzel, Thomas
- März, Winfried
- Cappola, Thomas P.
- Hirschhorn, Joel N.
- Mitchell, Gary F.
- Smith, Nicholas L.
- Dueker, Nicole D.
- Jaddoe, Vincent W.V.
- Melander, Olle
- Russ, Martin
- Lehtimäki, Terho
- Ciullo, Marina
- Hicks, Andrew A.
- Lind, Lars
- Gudnason, Vilmundur
- Pieske, Burkert
- Barron, Anthony J.
- Zweiker, Robert
- Schunkert, Heribert
- Ingelsson, Erik
- Liu, Kiang
- Arnett, Donna K.
- Psaty, Bruce M.
- Blankenberg, Stefan
- Larson, Martin G.
- Felix, Stephan B.
- Franco, Oscar H.
- Zeller, Tanja
- Vasan, Ramachandran S.
- Dörr, Marcus
- Venue
- Journal of Clinical Investigation
- Published
- 2017-04-10
- Volume
- 127
- Issue
- 5
- Pages
- 1798-1812
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC5409098
- OpenAlex
- W2604500500
- Cited by
- 129
- References
- 54
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 10 · 2023: 7 · 2022: 18 · 2021: 15 · 2020: 18 · 2019: 21 · 2018: 15 · 2017: 4
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Royal Devon and Exeter Research Repository (Royal Devon and Exeter) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Open Research (University of Surrey) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Apollo
- Funders
- Northwestern University (HHSN268201300027C, HHSN268201300028C, HHSN268200900041C, HHSN268201300026C, HHSN268201300025C, HHSN268201300029C)
- University of Minnesota (HHSN268201300025C, HHSN268201300029C, HHSN268201300028C, HHSN268201300026C, HHSN268200900041C, HHSN268201300027C)
- School of Medicine, Boston University
- Foundation for Cardiovascular Research
- Johns Hopkins University (HHSN268200900041C)
- University of Alabama at Birmingham (HHSN268201300027C, HHSN268201300026 C, HHSN268201300028C, HHSN268201300025C and HHSN268201300026C, HHSN268201300029C, HHSN268200900041C, HHSN268201300025C)
- Yrjö Jahnssonin Säätiö
- University of Alabama (HHSN268201300026 C, HHSN268201300025C)
- National Institute for Health and Care Research (NF-SI-0512-10165)
- British Heart Foundation (RG/13/13/30194, RG/08/014/24067)
- European Commission (018947, 201668, 01ZZ0103, 286284, 305739, 01ZZ0403, 03ZIK012, 01ZZ9603, LSHG-CT-2006-018947)
- Deutsche Forschungsgemeinschaft (01ZZ0403, 01ZZ9603, 03ZIK012, 01EO1003, 01ZZ0103)
- Stiftelsen för Strategisk Forskning (ICA08-0047)
- ZonMw (BMBF 01EO1003, 050-060-810)
- Kela
- Bundesministerium für Bildung und Forschung (01ZZ9603, 01ZZ0103, and 01ZZ0403, BMBF 01EO1003, 03ZIK012, 01ZZ0403, and 01ZZ0403, 01GS0837, 01EO1003, 01GS0422, 01ZZ0103, 01ZZ9603)
- Austrian Science Fund
- Suomen Kulttuurirahasto
- Crafoordska Stiftelsen
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (050.060.810, 911-03-012, 175.010.200, 175.010.2005.011)
- Lunds Universitet
- Lundbeckfonden (R190 2014-3904)
- Hjärt-Lungfonden (20120197)
- Juho Vainion Säätiö
- Signe ja Ane Gyllenbergin Säätiö
- Vetenskapsrådet (70374401, 80576801, 2012-01397)
- Emil Aaltosen Säätiö (286284, 201668, X51001)
- Akademiska Sjukhuset
- Sydäntutkimussäätiö (121584, 286284, 124282, X51001, 134309, 126925, 201668, 129378, 117787, 41071)
- Tampereen Tuberkuloosisäätiö (286284, 201668, X51001)
- Uppsala Universitet
- Svenska Läkaresällskapet
- Diabetesliitto
- Paavo Nurmen Säätiö
- Science for Life Laboratory
- Novo Nordisk Fonden (NNF16OC0021496)
- Skånes universitetssjukhus
- Provincia autonoma di Bolzano - Alto Adige
- National Institutes of Health (HHSN268200900041C, n01hc085082-026, n01hc085081-021, HHSN268201300026C, HHSN268201300028C, n01hc085079-024, HHSN268201300027C, n01hc085084-005, 1r01hl120393-01a1, HHSN268201300025C, n01hc085083-027, n01hc085080-026, UL1TR000124, n01hc085086-022, 201668, HHSN268201300050C, 305739, HHSN268201300029C, 01EO1003, 5u01hl054472-10, n01hc25195-41-0-1, n01hc55222-0-0-0, n01hc035129-010, HHSN 268201300048C, R24OD017870)
- Kaiser Foundation Research Institute (HHSN268201300029C, HHSN268201300028C, HHSN268200900041C, HHSN268201300025C, HHSN268201300026C, U01-HG004729, HHSN268201300027C)
- Medical Research Council (MR/L003120/1)
- European Regional Development Fund
- Helmholtz Zentrum München
- Universitätsmedizin der Johannes Gutenberg-Universität Mainz
- National Institute on Aging (HHSN268201300029C, HHSN268201300026C, HHSN268201300025C, HHSN268201300028C, R01AG023629, HHSN268200900041C, HHSN268201300027C)
- National Heart, Lung, and Blood Institute (HHSN268201300050C, HHSN268201300028C, U10HL054497, N01 HC085086, HHS-N2-68201300029C, HHSN268201300027C, U01-HL054472, N01 HC085079, R01-HL120393, N01 HC085083, HHSN268201500001I, U10HL054509, U01HL054495, U01HL054497, N01 HC085080, R01HL087652, R01HL103612, HHSN268200900041C, HHSN 268200800007C, N01 HC035129, HHSN268201300048C, HHSN268201500001C, U10HL054473, U01HL054496, U10HL054471, R01HL093328, U01HL130114, HHSN268201300026C, U01HL054471, HHS-N2-68201300025C, HHSN268201300049C, N01-HC-025195, HHSN268201200036C, R01HL107385, U10HL054495, N01HC085082, R01HL105756, U01HL080295, N01 HC055222, R01 HL, R00HL107642, U01HL054509, N01 HC085081, HHSN268201300047C, U01HL054473, R01HL126136, R01HL105993, U10HL054472, N01 HC085084, R01HL055673, R01HL131532, U10HL054496)
- National Human Genome Research Institute (U01HG04424, U01HG004446, U01HG004729, U01HG004424, HG004446)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063491, P30DK079626)
- National Institute of Neurological Disorders and Stroke (Z01NS002993, HHSN268200900041C, HHSN268201300028C, HHSN268201300026C, R01NS036286, HHSN268201300025C, HHSN268201300029C, R01 NS-36286, HHSN268201300027C)
- National Center for Advancing Translational Sciences
- National Institute on Minority Health and Health Disparities (HHSN268201300050C, HHSN268201300048C)
- Interreg
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- cardiac structure, cardiac function, left ventricular function, diastolic function, systolic function, aortic root diameter, genetic variants, single nucleotide polymorphisms, MTSS1, ATXN2, CACNA1C, TMEM16A
- MeSH terms
- Female, Heart Diseases, Humans, Male, Myocardium, Quantitative Trait, Heritable, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
