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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation
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Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone growth and differentiation, is expressed and regulated in osteoblastic cells. To investigate the role of FGF-2 in bone, we examined mice with a disruption of the Fgf2 gene. Measurement of trabecular bone architecture of the femoral metaphysis of Fgf2(+/+) and Fgf2(-/-) adult mice by micro-CT revealed that the platelike trabecular structures were markedly reduced and many of the connecting rods of trabecular bone were lost in the Fgf2(-/-) mice. Dynamic histomorphometry confirmed a significant decrease in trabecular bone volume, mineral apposition, and bone formation rates. In addition, there was a profound decreased mineralization of bone marrow stromal cultures from Fgf2(-/-) mice. This study provides strong evidence that FGF-2 helps determine bone mass as well as bone formation.
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“FGF-2 knockout mice showed a decreased bone mass coupled to increase of adipocytes in the bone marrow, indicating the participation of FGFs in the osteoblast differentiation [34].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [34]
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Metadata
- Authors
- Montero, A., Okada, Y., Tomita, M., Ito, M., Tsurukami, H., Nakamura, T., Doetschman, T., Coffin, J. D., & Hurley, M. M.
- Affiliations
- UConn Health (US)
- Nagasaki University (JP)
- University of Occupational and Environmental Health Japan (JP)
- University of Cincinnati (US)
- University of Montana (US)
- Corresponding author
- Hurley, Marja M.
- Venue
- Journal of Clinical Investigation
- Published
- 2000-04-15
- Volume
- 105
- Issue
- 8
- Pages
- 1085-1093
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC300831
- OpenAlex
- W2167091901
- Cited by
- 483
- References
- 84
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 16 · 2023: 7 · 2022: 7 · 2021: 20 · 2020: 24 · 2019: 17 · 2018: 13 · 2017: 15 · 2016: 21 · 2015: 28 · 2014: 22 · 2013: 27 · 2012: 24
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01ar046025-01a1, 7r01hl053631-05)
- National Heart, Lung, and Blood Institute (HL53631)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR46025)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- fibroblast growth factor 2, bone mass, bone formation, trabecular bone microarchitecture, osteoblasts, bone mineralization, mesenchymal stem cells, mineral apposition rate, femoral metaphysis
- MeSH terms
- Alkaline Phosphatase, Animals, Bone and Bones, Bone Marrow Cells, Cells, Cultured, Femur, Osteoblasts, Osteogenesis, RNA, Messenger, Skull, Tibia, Fibroblast Growth Factor 2, Mice, Knockout, Mice
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