Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Patel, A. P., Tirosh, I., Trombetta, J. J., Shalek, A. K., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., et al. (2014) · Science · doi:10.1126/science.1254257 · Cited by 5,063 · see citing works

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043 · see citing works

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993 · see citing works

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683 · see citing works

Cancer cachexia: understanding the molecular basis

Argilés, J. M. A., Busquets, S., Stemmler, B., & López-Soriano, F. J. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3829 · Cited by 1,518 · see citing works

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403 · see citing works

Biologically active sphingolipids in cancer pathogenesis and treatment

Öğretmen, B., & Hannun, Y. A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1411 · Cited by 1,216 · see citing works

The Phasor Approach to Fluorescence Lifetime Imaging Analysis

Digman, M. A., Caiolfa, V. R., Zamai, M., & Gratton, E. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.120154 · Cited by 1,150 · see citing works

Biological and therapeutic impact of intratumor heterogeneity in cancer evolution

McGranahan, N., & Swanton, C. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.001 · Cited by 1,077 · see citing works

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature · doi:10.1038/nature11743 · Cited by 1,007 · see citing works

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

Yue, S., Li, J., Lee, S. Y., Lee, H. J., Shao, T., Song, B., Liang Cheng, C., Masterson, T. A., Liu, X., Ratliff, T. L., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.019 · Cited by 931 · see citing works

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

Lee, C. D., Raffaghello, L., Brandhorst, S., Safdie, F. M., Bianchi, G., Martín‐Montalvo, A., Pistoia, V., Wei, M., Hwang, S., Merlino, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003293 · Cited by 715 · see citing works

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Birsoy, K., Possemato, R., Lorbeer, F. K., Bayraktar, E. C., Thiru, P., Yucel, B., Wang, T., Chen, W. W., Clish, C. B., & Sabatini, D. M. (2014) · Nature · doi:10.1038/nature13110 · Cited by 710 · see citing works

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

Dong, X., Shen, D., Wang, X., Dawson, T., Li, X., Zhang, Q., Cheng, X., Zhang, Y., Weisman, L. S., Delling, M., et al. (2010) · Nature Communications · doi:10.1038/ncomms1037 · Cited by 637 · see citing works

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

Edinger, A. L., & Thompson, C. B. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-12-0584 · Cited by 589 · see citing works

L‐asparaginase treatment in acute lymphoblastic leukemia: A focus on <i>Erwinia</i> asparaginase

Pieters, R., Hunger, S. P., Boos, J., Rizzari, C., Silverman, L., Baruchel, A., Goekbuget, N., Schrappe, M., & Pui, C. (2011) · Cancer · doi:10.1002/cncr.25489 · Cited by 569 · see citing works

Circumventing cancer drug resistance in the era of personalized medicine

Garraway, L. A., & Jänne, P. A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0012 · Cited by 503 · see citing works

Tumours with PI3K activation are resistant to dietary restriction

Kalaany, N. Y., & Sabatini, D. M. (2009) · Nature · doi:10.1038/nature07782 · Cited by 468 · see citing works

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

Pate, K. T., Stringari, C., Sprowl‐Tanio, S., Wang, K., TeSlaa, T., Hoverter, N. P., McQuade, M. M., Garner, C., Digman, M. A., Teitell, M. A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488598 · Cited by 459 · see citing works

The utilization of extracellular proteins as nutrients is suppressed by mTORC1

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., & Thompson, C. B. (2015) · Cell · doi:10.1016/j.cell.2015.06.017 · Cited by 457 · see citing works

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

Guillaumond, F., Bidaut, G., Ouaissi, M., Servais, S., Gouirand, V., Olivares, O., Lac, S., Borge, L., Roques, J., Gayet, O., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421601112 · Cited by 454 · see citing works

Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue

Stringari, C., Cinquin, A., Cinquin, O., Digman, M. A., Donovan, P. J., & Gratton, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108161108 · Cited by 434 · see citing works

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

Garcı́a-Cao, I., Song, M. S., Hobbs, R. M., Laurent, G., Giorgi, C., de Boer, V. C. J., Anastasiou, D., Ito, K., Sasaki, A. T., Rameh, L. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.030 · Cited by 403 · see citing works

Metabolic Mapping of MCF10A Human Breast Cells via Multiphoton Fluorescence Lifetime Imaging of the Coenzyme NADH

Bird, D. K., Yan, L., Vrotsos, K. M., Eliceiri, K. W., Vaughan, E. M., Keely, P. J., White, J. G., & Ramanujam, N. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3922 · Cited by 373 · see citing works

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphocytic leukemia

Neviani, P., Santhanam, R., Oaks, J. J., Eiring, A. M., Notari, M., Blaser, B. W., Liu, S., Trotta, R., Muthusamy, N., Gambacorti-Passerini, C. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31095 · Cited by 337 · see citing works

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

Jefferies, H. B. J., Cooke, F. T., Jat, P., Boucheron, C., Koizumi, T., Hayakawa, M., Kaizawa, H., Ohishi, T., Workman, P., Waterfield, M. D., et al. (2008) · EMBO Reports · doi:10.1038/sj.embor.7401155 · Cited by 305 · see citing works

Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A

Chalfant, C. E., Kishikawa, K., Mumby, M. C., Kamibayashi, C., Bielawska, A. E., & Hannun, Y. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20313 · Cited by 300 · see citing works

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport

Rutherford, A. C., Traer, C. J., Wassmer, T., Pattni, K., Bujny, M. V., Carlton, J. G., Stenmark, H., & Cullen, P. J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03153 · Cited by 279 · see citing works

PI(5)P Regulates Autophagosome Biogenesis

Vicinanza, M., Korolchuk, V. I., Ashkenazi, A., Puri, C., Menzies, F. M., Clarke, J. H., & Rubinsztein, D. C. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.007 · Cited by 256 · see citing works

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

Shroff, E. H., Eberlin, L. S., Dang, V. M., Gouw, A. M., Gabay, M., Adam, S. J., Bellovin, D. I., Tran, P. T., Philbrick, W. M., Garcia-Ocana, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507228112 · Cited by 255 · see citing works

Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH

Stringari, C., Edwards, R. A., Pate, K. T., Waterman, M. L., Donovan, P. J., & Gratton, E. (2012) · Scientific Reports · doi:10.1038/srep00568 · Cited by 251 · see citing works

Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ

Schwartz, S., Wongvipat, J., Trigwell, C. B., Hancox, U. J., Carver, B. S., Rodrik-Outmezguine, V. S., Will, M., Yellen, P., de Stanchina, E., Baselga, J. M., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.11.008 · Cited by 247 · see citing works

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

Wang, W., Gao, Q., Yang, M., Zhang, X., Yu, L., Lawas, M., Li, X., Bryant-Genevier, M. G., Southall, N. T., Marugán, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419669112 · Cited by 243 · see citing works

In vivo, Pikfyve generates PI(3,5)P 2 , which serves as both a signaling lipid and the major precursor for PI5P

Zolov, S. N., Bridges, D., Zhang, Y., Lee, W.-W., Riehle, E., Verma, R., Lenk, G. M., Converso‐Baran, K., Weide, T., Albin, R. L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203106109 · Cited by 235 · see citing works

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

Cai, X., Xu, Y., Cheung, A. K., Tomlinson, R., Alcázar-Román, A. R., Murphy, L. O., Billich, A., Zhang, B., Feng, Y., Klumpp, M., et al. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.05.010 · Cited by 225 · see citing works

Phosphatidylinositol 3,5‐bisphosphate: Low abundance, high significance

McCartney, A. J., Zhang, Y., & Weisman, L. S. (2013) · BioEssays · doi:10.1002/bies.201300012 · Cited by 212 · see citing works

Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

Camm, A. J., Hla, T., Bakshi, R., & Brinkmann, V. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.06.028 · Cited by 212 · see citing works

Lipid metabolism in prostate cancer.

Wu, X., Daniels, G., Lee, P., & Monaco, M. E. (2014) · PubMed Central · Cited by 205 · see citing works

Ceramide starves cells to death by downregulating nutrient transporter proteins

Guenther, G., Peralta, E. R., Rosales, K. R., Wong, S. Y., Siskind, L. J., & Edinger, A. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802781105 · Cited by 194 · see citing works

Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

Azuma, H., Takahara, S., Ichimaru, N., Wang, J. D., Itoh, Y., Otsuki, Y., Morimoto, J., Fukui, R., Hoshiga, M., Ishihara, T., et al. (2002) · PubMed · Cited by 193 · see citing works

Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand

Bauer, D. E., Harris, M. H., Plas, D. R., Lum, J. J., Hammerman, P. S., Rathmell, J. C., Riley, J. L., & Thompson, C. B. (2004) · The FASEB Journal · doi:10.1096/fj.03-1001fje · Cited by 188 · see citing works

Exploiting the bad eating habits of Ras-driven cancersPreprint

White, E. (2013) · Genes & Development · doi:10.1101/gad.228122.113 · Cited by 177 · see citing works

Characterization of Cholesterol Crystals in Atherosclerotic Plaques Using Stimulated Raman Scattering and Second-Harmonic Generation Microscopy

Suhalim, J. L., Chung, C., Lilledahl, M. B., Lim, R. S., Levi, M., Tromberg, B. J., & Potma, E. O. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.03.016 · Cited by 154 · see citing works

Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics

Li, X., Wang, X., Zhang, X., Zhao, M., Tsang, W. L., Zhang, Y., Yau, R. G., Weisman, L. S., & Xu, H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311864110 · Cited by 148 · see citing works

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Chalfant, C. E., Szulc, Z. M., Roddy, P. L., Bielawska, A. E., & Hannun, Y. A. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300347-jlr200 · Cited by 141 · see citing works

In Vivo Single-Cell Detection of Metabolic Oscillations in Stem Cells

Stringari, C., Wang, H., Geyfman, M., Crosignani, V., Kumar, V., Takahashi, J. S., D, B. A. M., & Gratton, E. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.007 · Cited by 131 · see citing works

Nutrient transporters: the Achilles’ heel of anabolism

McCracken, A. N., & Edinger, A. L. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.01.002 · Cited by 113 · see citing works

Induction of Apoptosis in Human Bladder Cancer Cells In Vitro and In Vivo Caused by FTY720 Treatment

Azuma, H., Takahara, S., Horie, S., Muto, S., Otsuki, Y., & Katsuoka, Y. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000064938.32318.91 · Cited by 109 · see citing works

AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve

Er, E. E., Mendoza, M. C., Mackey, A. M., Rameh, L. E., & Blenis, J. (2013) · Science Signaling · doi:10.1126/scisignal.2004015 · Cited by 104 · see citing works

Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo

Kono, M., Tucker, A. E., Tran, J., Bergner, J. B., Turner, E. M., & Proia, R. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71194 · Cited by 101 · see citing works

Choline PET and PET/CT in Primary Diagnosis and Staging of Prostate Cancer

Schwarzenböck, S. M., Souvatzoglou, M., & Krause, B. J. (2012) · Theranostics · doi:10.7150/thno.4008 · Cited by 100 · see citing works

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

Kerr, M. C., Wang, J. T. H., Castro, N. A., Hamilton, N., Town, L., Brown, D. L., Meunier, F. A., Brown, N. F., Stow, J. L., & Teasdale, R. D. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.28 · Cited by 96 · see citing works

Arginine deprivation in cancer therapy

Feun, L. G., Kuo, M. T., & Savaraj, N. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000122 · Cited by 84 · see citing works

Attacking the supply wagons to starve cancer cells to death

Selwan, E. M., Finicle, B. T., Kim, S. M., & Edinger, A. L. (2016) · FEBS Letters · doi:10.1002/1873-3468.12121 · Cited by 70 · see citing works

Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2 and PI(5)P

Zhang, Y., McCartney, A. J., Zolov, S. N., Ferguson, C., Meisler, M. H., Sutton, M. A., & Weisman, L. S. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.200 · Cited by 53 · see citing works

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

Rosales, K. R., Singh, G., Wu, K. C. ‐., Chen, J., Janes, M. R., Lilly, M. B., Peralta, E. R., Siskind, L. J., Bennett, M. J., Fruman, D. A., et al. (2011) · Biochemical Journal · doi:10.1042/bj20110853 · Cited by 46 · see citing works

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner

Gault, C. R., Eblen, S. T., Neumann, C. A., Hannun, Y. A., & Obeid, L. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.385765 · Cited by 44 · see citing works

Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo

Chen, B., Roy, S. G., McMonigle, R. J., Keebaugh, A. J., McCracken, A. N., Selwan, E. M., Fransson, R., Fallegger, D., Huwiler, A., Kleinman, M. T., et al. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00761 · Cited by 29 · see citing works

Starvation in the midst of plenty: making sense of ceramide-induced autophagy by analysing nutrient transporter expression

Edinger, A. L. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370253 · Cited by 27 · see citing works

Genetic, Biochemical, and Transcriptional Responses of Saccharomyces cerevisiae to the Novel Immunomodulator FTY720 Largely Mimic Those of the Natural Sphingolipid Phytosphingosine

Welsch, C. A., Roth, L., Goetschy, J., & Movva, N. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406179200 · Cited by 26 · see citing works

Untitled work

Kolb (2001) · doi:10.1002/1521-3773(20010601)40:11

Cancer Cell Membrane Camouflaged Cascade Bioreactor for Cancer Targeted Starvation and Photodynamic Therapy

Li, S., Cheng, H. B., Xie, B., Qiu, W., Zeng, J.-Y., Li, C., Wan, S., Zhang, L., Liu, W., & Zhang, X. (2017) · ACS Nano · doi:10.1021/acsnano.7b02533 · Cited by 783 · see citing works

Cell membrane modulation as adjuvant in cancer therapy

Zalba, S., & ten Hagen, T. L. M. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.10.008 · Cited by 367 · see citing works

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.03.007 · Cited by 299 · see citing works

Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics

Haensel, D., Jin, S., Sun, P., Cinco, R., Dragan, M., Nguyen, Q., Cang, Z., Gong, Y., Vu, R., MacLean, A. L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.091 · Cited by 236 · see citing works

Nutrient scavenging in cancer

Finicle, B. T., Jayashankar, V., & Edinger, A. L. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0048-x · Cited by 231 · see citing works

PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells

Kim, S. M., Nguyen, T. T., Ravi, A., Kubiniok, P., Finicle, B. T., Jayashankar, V., Malacrida, L., Hou, J., Robertson, J., Gao, D., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1215 · Cited by 199 · see citing works

Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy

Zhang, Z., Sang, W., Xie, L., & Dai, Y. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2019.213022 · Cited by 157 · see citing works

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Choy, C. H., Saffi, G. T., Gray, M. A., Wallace, C. T., Dayam, R. M., Ou, Z.-Y. A., Lenk, G. M., Puertollano, R., Watkins, S. C., & Botelho, R. J. (2018) · Journal of Cell Science · doi:10.1242/jcs.213587 · Cited by 147 · see citing works

Combined Fenton and starvation therapies using hemoglobin and glucose oxidase

Ranji‐Burachaloo, H., Reyhani, A., Gurr, P. A., Dunstan, D. E., & Qiao, G. G. (2019) · Nanoscale · doi:10.1039/c8nr09107b · Cited by 135 · see citing works

Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration

Clark, A. R., & Ohlmeyer, M. H. J. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.016 · Cited by 106 · see citing works

A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy

Zhang, X., Cheng, L., Lu, Y., Tang, J., Lv, Q., Chen, X., Chen, Y., & Liu, J. (2021) · Nano-Micro Letters · doi:10.1007/s40820-021-00761-w · Cited by 94 · see citing works

Cancer cell cannibalism: Multiple triggers emerge for entosis

Durgan, J., & Florey, O. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.03.004 · Cited by 84 · see citing works

Targeting the duality of cancer

Arbiser, J. L., Bonner, M. Y., & Gilbert, L. C. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0026-x · Cited by 71 · see citing works

Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations

Ikonomov, O. C., Sbrissa, D., & Shisheva, A. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114771 · Cited by 70 · see citing works

Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters

Yu, W., Wang, Z., Yu, X., Zhao, Y., Xie, Z., Zhang, K., Chi, Z., Chen, S., Xu, T., Jiang, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31149-y · Cited by 66 · see citing works

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

Krstic, J., Reinisch, I., Schindlmaier, K., Galhuber, M., Riahi, Z., Berger, N., Kupper, N., Moyschewitz, E., Auer, M., Michenthaler, H., et al. (2022) · Science Advances · doi:10.1126/sciadv.abh2635 · Cited by 64 · see citing works

Nutrient Sensing in Cancer

Torrence, M. E., & Manning, B. D. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050329 · Cited by 52 · see citing works

Merlin/ERM proteins regulate growth factor-induced macropinocytosis and receptor recycling by organizing the plasma membrane:cytoskeleton interfacePreprint

Chiasson-MacKenzie, C., Morris, Z. S., Liu, C.-H., Bradford, W. B., Koorman, T., & McClatchey, A. I. (2018) · Genes & Development · doi:10.1101/gad.317354.118 · Cited by 47 · see citing works

ONC212 is a Novel Mitocan Acting Synergistically with Glycolysis Inhibition in Pancreatic Cancer

Ferrarini, I., Louie, A. D., Zhou, L., & El‐Deiry, W. S. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0962 · Cited by 44 · see citing works

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

Lima, S., Takabe, K., Newton, J. C., Saurabh, K., Young, M. M., Leopoldino, A. M., Hait, N. C., Roberts, J. L., Wang, H., Dent, P., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1429875 · Cited by 42 · see citing works

Macropinocytosis and autophagy crosstalk in nutrient scavenging

Florey, O., & Overholtzer, M. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0154 · Cited by 39 · see citing works

Intracellular Transport in Cancer Metabolic Reprogramming

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Ubiquitylation and endocytosis of the human LAT1/SLC7A5 amino acid transporter

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FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia

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Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity

Jayashankar, V., Selwan, E. M., Hancock, S. E., Verlande, A., Goodson, M. O., Eckenstein, K. H., Milinkeviciute, G., Hoover, B., Chen, B., Fleischman, A. G., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013086 · Cited by 31 · see citing works

Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

Finicle, B. T., Eckenstein, K. H., Revenko, A. S., Anderson, B. A., Wan, W. B., McCracken, A. N., Gil, D., Fruman, D. A., Hanessian, S., Seth, P. P., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad023 · Cited by 29 · see citing works

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

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PP2A and cancer epigenetics: a therapeutic opportunity waiting to happen

Tinsley, S. L., & Allen-Petersen, B. L. (2022) · NAR Cancer · doi:10.1093/narcan/zcac002 · Cited by 25 · see citing works

A NUMB–EFA6B–ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility

Zobel, M., Disanza, A., Senic-Matuglia, F., Franco, M., Colaluca, I. N., Confalonieri, S., Bisi, S., Barbieri, E., Caldieri, G., Sigismund, S., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201802023 · Cited by 24 · see citing works

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

Wible, D. J., Parikh, Z., Cho, E. J., Chen, M.-D., Jeter, C. R., Mukhopadhyay, S., Dalby, K. N., Varadarajan, S., & Bratton, S. B. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06423-0 · Cited by 24 · see citing works

Drug-Induced Self-Assembly Cascade Nanoreactor for Synergistic Tumor Therapy

Wang, W., Wang, Y., Ma, M., Jin, H. J., & Li, X. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c09947 · Cited by 22 · see citing works

Understanding the regulatory landscape of protein phosphatase 2A (PP2A): Pharmacological modulators and potential therapeutics

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Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells

Thomas, N., Schröder, N. H., Nowak, M. K., Wollnitzke, P., Ghaderi, S., Lipinski, K. V. W., Wille, A., Deister-Jonas, J., Vogt, J., Gräler, M. H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-44109-x · Cited by 21 · see citing works

Cascade-reaction-triggered engineering nanocatalytic theranostics reconstructing tumor microenvironment through synergistic oxidative damage and aerobic glycolysis inhibition against colon cancer

Yao, Y., Xu, Y., Zhao, X., Chen, H., & Tan, N. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138336 · Cited by 20 · see citing works

Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis

Filippakis, H., Belaïd, A., Siroky, B. J., Wu, C., Alesi, N., Hougard, T. R., Nijmeh, J., Lam, H. C., & Henske, E. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-32256-x · Cited by 19 · see citing works

Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts

Karsai, G., Steiner, R., Kaech, A., Lone, M. A., von Eckardstein, A., & Hornemann, T. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100122 · Cited by 17 · see citing works

FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition

Barthelemy, C., Barry, A. O., Twyffels, L., & André, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-14124-2 · Cited by 19 · see citing works

Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs

Kubiniok, P., Finicle, B. T., Piffaretti, F., McCracken, A. N., Perryman, M. S., Hanessian, S., Edinger, A. L., & Thibault, P. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.001053 · Cited by 17 · see citing works

Biomimetic Cascade Polymer Nanoreactors for Starvation and Photodynamic Cancer Therapy

Liu, S., Yan, T., Sun, J., Li, F., Xu, J., Sun, H., Yu, S., & Liu, J. (2021) · Molecules · doi:10.3390/molecules26185609 · Cited by 15 · see citing works

“Domino” cascade reactor based on DNA hydrogel for synergistic treatment of malignant tumor

Liu, X., Ma, M., Tian, S., Wang, W., & Li, X. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115441 · Cited by 15 · see citing works

Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomicsPreprint

Haensel, D., Jin, S., Cinco, R., Sun, P., Nguyen, Q., Cang, Z., Dragan, M., Gong, Y., MacLean, A. L., Kessenbrock, K., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/793117 · Cited by 15 · see citing works

PIKfyve, expressed by CD11c-positive cells, controls tumor immunity

Choi, J. E., Qiao, Y., Kryczek, I., Yu, J., Gurkan, J. K., Bao, Y., Gondal, M. N., Tien, J. C.-Y., Maj, T., Yazdani, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48931-9 · Cited by 14 · see citing works

Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines

Bachollet, S. P. J. T., Vece, V., McCracken, A. N., Finicle, B. T., Selwan, E. M., Romdhane, N. B., Dahal, A., Ramirez, C. B., Edinger, A. L., & Hanessian, S. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00553 · Cited by 14 · see citing works

Branched chain amino acid metabolism and cancer: the importance of keeping things in context

Selwan, E. M., & Edinger, A. L. (2017) · Translational Cancer Research · doi:10.21037/tcr.2017.05.05 · Cited by 14 · see citing works

Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex

Kovalenko, A., Sanin, A., Kosmas, K., Zhang, L., Wang, J., Akl, E. W., Giannikou, K., Probst, C. K., Hougard, T. R., Rue, R. W., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2218 · Cited by 13 · see citing works

In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways

Garsi, J.-B., Sernissi, L., Vece, V., Hanessian, S., McCracken, A. N., Simitian, G. S., & Edinger, A. L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.043 · Cited by 12 · see citing works

Caveolin-1 mediates the utilization of extracellular proteins for survival in refractory gastric cancer

Hwang, N., Yoon, B. K., Chun, K.-H., Kim, H., Lee, Y., Kim, J.-W., Jeon, H., Kim, T., Kim, M. Y., Fang, S., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01109-7 · Cited by 11 · see citing works

Biocompatible Chemotherapy for Leukemia by Acid-Cleavable, PEGylated FTY720

Kemp, J. A., Keebaugh, A. J., Edson, J. A., Chow, D. T., Kleinman, M. T., Chew, Y. C., McCracken, A. N., Edinger, A. L., & Kwon, Y. J. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00822 · Cited by 9 · see citing works

Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis

Blais‐Lecours, P., Laouafa, S., Arias‐Reyes, C., Santos, W. L., Joseph, V., Burgess, J. K., Halayko, A. J., Soliz, J., & Marsolais, D. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0397oc · Cited by 9 · see citing works

Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A

Garsi, J.-B., Vece, V., Sernissi, L., Auger-Morin, C., Hanessian, S., McCracken, A. N., Selwan, E. M., Ramirez, C. B., Dahal, A., Romdhane, N. B., et al. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.07.023 · Cited by 9 · see citing works

Fuse your mitochondria, lose appetite: an anorexic, anti‐obesity sphingolipid

Muley, C., & Bartelt, A. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114618 · Cited by 8 · see citing works

Pacritinib inhibits glucose consumption in squamous cell lung cancer cells by targeting FLT3

Ghezzi, C., Chen, B. Y., Damoiseaux, R. D., & Clark, P. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-28576-2 · Cited by 7 · see citing works

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A

Jayashankar, V., Kubiniok, P., McCracken, A. N., Gentry, R. G., Eckenstein, K. H., Sernissi, L., Vece, V., Garsi, J.-B., Valles, S. Y., Jung, S., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00490-5 · Cited by 5 · see citing works

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

Lü, Z., Lai, Q., Li, Z., Zhong, M., Jiang, Y., Feng, L.-Y., Zha, J., Yao, J., Yin, L., Deng, X., et al. (2024) · Current Medical Science · doi:10.1007/s11596-024-2847-5 · Cited by 5 · see citing works

Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel

Duse, D. A., Schröder, N. H., Srivastava, T., Benkhoff, M., Vogt, J., Nowak, M. K., Funk, F., Semleit, N., Wollnitzke, P., Erkens, R., et al. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01073-x · Cited by 4 · see citing works

The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells

Chintaluri, K., Goulden, B. D., Celmenza, C., Saffi, G. T., Miraglia, E., Hammond, G. R. V., & Botelho, R. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198454 · Cited by 4 · see citing works

Is cell migration a selectable trait in the natural evolution of cancer development?

Disanza, A., Bisi, S., Frittoli, E., Malinverno, C., Marchesi, S., Palamidessi, A., Rizvi, A., & Scita, G. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0224 · Cited by 4 · see citing works

Quantitative Assessment of Macropinocytosis in mTORC1-Hyperactive Cells using Flow Cytometry

Belaïd, A., & Filippakis, H. (2021) · Journal of Visualized Experiments · doi:10.3791/62793 · Cited by 3 · see citing works

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Choy, C. H., Saffi, G. T., Gray, M. A., Wallace, C. T., Dayam, R. M., Ou, Z.-Y. A., Lenk, G. M., Puertollano, R., Watkins, S. C., & Botelho, R. (2023) · doi:10.32920/21982919 · Cited by 3 · see citing works

Methylglyoxal: Hijack-to-survive paradigm of cancer progression

Patel, M. D., Rawal, S. K., & Mani, S. (2026) · Gene Reports · doi:10.1016/j.genrep.2026.102455 · Cited by 1 · see citing works

Cascade-Reaction-Triggered Engineering Nanocatalytic Theranostics Reconstructing Tumor Microenvironment Through Synergistic Oxidative Damage and Aerobic Glycolysis Inhibition Against Colon CancerPreprint

Tan, N., Yao, Y., Xu, Y., Zhao, X., & Chen, H. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.3994401

Regulation of lysosome biogenesis by phosphoinositides and phagocytosis

Choy, C. (2021) · doi:10.32920/ryerson.14648823.v1

The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells

Chintaluri, K. (2021) · doi:10.32920/ryerson.14661819.v1

The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells

Chintaluri, K. (2021) · doi:10.32920/ryerson.14661819

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Choy, C. H., Saffi, G. T., Gray, M. A., Wallace, C. T., Dayam, R. M., Ou, Z.-Y. A., Lenk, G. M., Puertollano, R., Watkins, S. C., & Botelho, R. (2023) · doi:10.32920/21982919.v1

The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells

Chintaluri, K., Goulden, B. D., Celmenza, C., Saffi, G. T., Miraglia, E., Hammond, G. R. V., & Botelho, R. (2023) · doi:10.32920/21982877.v1

The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells

Chintaluri, K., Goulden, B. D., Celmenza, C., Saffi, G. T., Miraglia, E., Hammond, G. R. V., & Botelho, R. (2023) · doi:10.32920/21982877

Data from Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex

Kovalenko, A., Sanin, A., Kosmas, K., Zhang, L., Wang, J., Akl, E. W., Giannikou, K., Probst, C. K., Hougard, T. R., Rue, R. W., et al. (2023) · doi:10.1158/0008-5472.c.6513499.v1

PP2A activation drives aberrant macropinocytosis and cell death in pancreatic ductal adenocarcinomaPreprint

Baral, G., Pfeffer, C. M., Filippelli, S. N., Doraivel, I., Heil, B. N., Gartenhaus, L. E., Hansen, K., Wu, J., Narla, G., Doud, E. H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.14.664742

Polypharmacologic phosphoinositide modulation by FTY720 triggers endomembrane trafficking collapse and metabolic starvation in cancer cells

Kofuji, S., Sumita, K., Ikeda, Y., Takahashi, Y., Tabata, S., Ito, D., Hirota, Y., Sasaki, M., Kanoh, H. X., Nakatsu, F., et al. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153671

Le rôle de la lipide kinase PIKfyve dans le remodelage ventriculaire et l'insuffisance cardiaque : vers de nouvelles perspectives thérapeutiques

Cinato, M. (2018) · doi:10.70675/b86d3460zb434z4543z83afz44c41dbb03c1

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Zheng, L., Guo, S., Luo, Y., Wu, P., Yang, H., Xie, Y., Fan, Y., Liu, Q. H., Hu, B., Huang, J., et al. (2026) · Advanced Science · doi:10.1002/advs.202519290

Endolysosomal trafficking regulator SH-BC-893 inhibits coronavirus entry in vitro and in vivo

Finicle, B. T., Perrochon, A. S., Chu, B., Buchmeier, M. J., & Edinger, A. L. (2026) · Scientific Reports · doi:10.1038/s41598-026-51335-y

Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy

Ou, M., Liu, Y., Luo, R., Cao, J., Miao, R., Li, W., Wang, X., Fu, Y., & Mei, L. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115156

Simultaneously inhibiting multiple nutrient acquisition pathways using synthetic sphingolipid compounds

Kim, S. M. (2016) · eScholarship (California Digital Library)

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

Rosales, K. R., Singh, G., Wu, K. C. ‐., Chen, J., Janes, M. R., Lilly, M. B., Peralta, E. R., Siskind, L. J., Bennett, M. J., Fruman, D. A., et al. (2011) · Biochemical Journal · doi:10.1042/bj20110853 · Cited by 46 · see citing works

Starving cancer: the molecular mechanisms of nutrient transporter loss induced by anti-neoplastic sphingolipids

Ramirez, M. U. (2017) · eScholarship (California Digital Library)

Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

O'Connell, C. E., & Vassilev, A. P. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3371 · Cited by 30 · see citing works

Targeting tumour cells at the entrance

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