L‐asparaginase treatment in acute lymphoblastic leukemia: A focus on Erwinia asparaginase
Open accessAbstract
Asparaginases are a cornerstone of treatment protocols for acute lymphoblastic leukemia (ALL) and are used for remission induction and intensification treatment in all pediatric regimens and in the majority of adult treatment protocols. Extensive clinical data have shown that intensive asparaginase treatment improves clinical outcomes in childhood ALL. Three asparaginase preparations are available: the native asparaginase derived from Escherichia coli (E. coli asparaginase), a pegylated form of this enzyme (PEG-asparaginase), and a product isolated from Erwinia chrysanthemi, ie, Erwinia asparaginase. Clinical hypersensitivity reactions and silent inactivation due to antibodies against E. coli asparaginase, lead to inactivation of E. coli asparaginase in up to 60% of cases. Current treatment protocols include E. coli asparaginase or PEG-asparaginase for first-line treatment of ALL. Typically, patients exhibiting sensitivity to one formulation of asparaginase are switched to another to ensure they receive the most efficacious treatment regimen possible. Erwinia asparaginase is used as a second- or third-line treatment in European and US protocols. Despite the universal inclusion of asparaginase in such treatment protocols, debate on the optimal formulation and dosage of these agents continues. This article provides an overview of available evidence for optimal use of Erwinia asparaginase in the treatment of ALL.
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Depletion of plasma asparagine by recombinant bacterial L-Asparaginase is effective anticancer intervention for acute lymphoblastic leukemia.
“Depletion of plasma asparagine by a recombinant form of bacterial L-Asparaginase is an effective anticancer intervention for this cancer type (Hill et al., 1967; Pieters et al., 2011).”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Pieters et al., 2011
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- Authors
- Pieters, R., Hunger, S. P., Boos, J., Rizzari, C., Silverman, L., Baruchel, A., Goekbuget, N., Schrappe, M., & Pui, C.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Children's Hospital Colorado (US)
- University of Münster (DE)
- Azienda Ospedaliera San Gerardo (IT)
- Boston Children's Hospital (US)
- University Hospital Frankfurt (DE)
- University Hospital Schleswig-Holstein (DE)
- Corresponding author
- Pieters, Rob
- Pui, Ching‐Hon
- ORCID
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2010-09-07
- Volume
- 117
- Issue
- 2
- Pages
- 238-249
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- PMC
- PMC3000881
- OpenAlex
- W1965542498
- Cited by
- 569
- References
- 74
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 35 · 2023: 38 · 2022: 49 · 2021: 53 · 2020: 56 · 2019: 43 · 2018: 41 · 2017: 41 · 2016: 39 · 2015: 37 · 2014: 42 · 2013: 28 · 2012: 18
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- National Cancer Institute (CA21765, P01CA020180, P30CA021765)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- L-asparaginase, acute lymphoblastic leukemia, PEG-asparaginase, pediatric leukemia, treatment protocols, dose optimization
- MeSH terms
- Asparaginase, Drug Combinations, Drug Hypersensitivity, Erwinia, Humans, Spironolactone, Sulfonamides, Drug Monitoring, Precursor Cell Lymphoblastic Leukemia-Lymphoma
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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