The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Islet inflammation in type 2 diabetes and physiology
Open accessAbstract
The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell dysfunction has further highlighted the significance of inflammation in metabolic diseases. The number of intra-islet macrophages is increased in T2D, and these cells are the main source of proinflammatory cytokines within islets. Multiple human studies of T2D have shown that targeting islet inflammation has the potential to be an effective therapeutic strategy. In this Review we provide an overview of the cellular and molecular mechanisms by which islet inflammation develops and causes β cell dysfunction. We also emphasize the regulation and roles of macrophage polarity shift within islets in the context of T2D pathology and β cell health, which may have broad translational implications for therapeutics aimed at improving islet function.
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1 retracted
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Inflammation and metabolic disorders
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Cited by
Inflammatory mechanisms linking obesity and metabolic disease
Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection
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Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274
Role of Cellular Senescence in Type II Diabetes
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Ding, L.-N., Ding, W.-Y., Ning, J., Wang, Y., Yan, Y., & Wang, Z.-B. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.770861 · Cited by 49
Metadata
- Authors
- Eguchi, K., & Nagai, R.
- Venue
- Journal of Clinical Investigation
- Published
- 2017-01-03
- Volume
- 127
- Issue
- 1
- Pages
- 14-23
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2566820606
- Cited by
- 361
- References
- 113
- FWCI
- 27.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
