Role of Cellular Senescence in Type II Diabetes
Open accessAbstract
Cellular senescence is a cell fate that occurs in response to numerous types of stress and can promote tissue repair or drive inflammation and disruption of tissue homeostasis depending on the context. Aging and obesity lead to an increase in the senescent cell burden in multiple organs. Senescent cells release a myriad of senescence-associated secretory phenotype factors that directly mediate pancreatic β-cell dysfunction, adipose tissue dysfunction, and insulin resistance in peripheral tissues, which promote the onset of type II diabetes mellitus. In addition, hyperglycemia and metabolic changes seen in diabetes promote cellular senescence. Diabetes-induced cellular senescence contributes to various diabetic complications. Thus, type II diabetes is both a cause and consequence of cellular senescence. This review summarizes recent studies on the link between aging, obesity, and diabetes, focusing on the role of cellular senescence in disease processes.
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Senescent cell clearance improves glucose homeostasis and insulin sensitivity in obese and aged mice.
“Senescent cell clearance improved glucose homeostasis and insulin sensitivity in obese and aged mice103.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [103]
The Adipose Tissue Senescence and Inflammation section reports that senolytics significantly improve glucose tolerance and insulin sensitivity in mice on a high-fat diet, supporting the claim for obese mice. The copy does not report those improvements following senescent-cell clearance in aged mice; its discussion of old mice concerns senescence markers and insulin resistance. Page numbers are unavailable in the indexed passages. (LLM, conf=0.88)
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The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · see citing works
Diabetic Kidney Disease: Challenges, Progress, and Possibilities
Alicic, R. Z., Rooney, M. T., & Tuttle, K. R. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11491116 · Cited by 2,898 · see citing works
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708 · see citing works
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works
Hallmarks of Cellular Senescence
Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605 · see citing works
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works
Self-citationSenolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works
Self-citationAdvanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury
Goldin, A., Beckman, J. A., Schmidt, A. M., & Creager, M. A. (2006) · Circulation · doi:10.1161/circulationaha.106.621854 · Cited by 2,261 · see citing works
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819 · see citing works
Senescence in Health and Disease
He, S., & Sharpless, N. E. (2017) · Cell · doi:10.1016/j.cell.2017.05.015 · Cited by 1,766 · see citing works
Cellular senescence mediates fibrotic pulmonary disease
Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · see citing works
Self-citationInk4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486 · see citing works
Senescence-associated β-galactosidase is lysosomal β-galactosidase.
Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., DiMaio, D., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00199.x · Cited by 1,444 · see citing works
Genomic Instability in Mice Lacking Histone H2AX
Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385 · see citing works
Senescent cells: an emerging target for diseases of ageing
Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.116 · Cited by 1,284 · see citing works
CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Silverstein, R. L., & Febbraio, M. (2009) · Science Signaling · doi:10.1126/scisignal.272re3 · Cited by 1,247 · see citing works
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186 · see citing works
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143 · see citing works
Senescence in tumours: evidence from mice and humans
Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2772 · Cited by 1,124 · see citing works
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92172 · Cited by 1,114 · see citing works
Cellular Senescence in Aging Primates
Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works
Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus
Nowotny, K., Jung, T., Höhn, A., Weber, D., & Grune, T. (2015) · Biomolecules · doi:10.3390/biom5010194 · Cited by 1,095 · see citing works
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., & Evans, R. M. (2001) · Nature Medicine · doi:10.1038/83336 · Cited by 1,069 · see citing works
Fisetin is a senotherapeutic that extends health and lifespan
Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032 · see citing works
Self-citationGlucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215318 · Cited by 1,006 · see citing works
p16INK4a induces an age-dependent decline in islet regenerative potential
Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003 · see citing works
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Kang, C., Xu, Q., Martin, T. D., Li, M. Z., Demaria, M., Aron, L., Lu, T., Yankner, B. A., Campisi, J., & Elledge, S. J. (2015) · Science · doi:10.1126/science.aaa5612 · Cited by 982 · see citing works
An aged immune system drives senescence and ageing of solid organs
Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature · doi:10.1038/s41586-021-03547-7 · Cited by 972 · see citing works
Self-citationSenescence and apoptosis: dueling or complementary cell fates?
Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J., & van Deursen, J. M. (2014) · The EMBO Reports · doi:10.15252/embr.201439245 · Cited by 915 · see citing works
β-Cell Glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes.
Robertson, R. P., Harmon, J., Tran, P. O. T., & Poitout, V. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s119 · Cited by 914 · see citing works
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796 · see citing works
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
Ehses, J. A., Perren, A. A., Eppler, E., Ribaux, P., Pospisilik, J. A., Maor-Cahn, R., Guéripel, X., Ellingsgaard, H., Schneider, M. K. J., Biollaz, G., et al. (2007) · Diabetes · doi:10.2337/db06-1650 · Cited by 783 · see citing works
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731 · see citing works
Lee, B.-C., & Lee, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.017 · Cited by 697 · see citing works
DNA damage response and cellular senescence in tissues of aging mice
Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature · doi:10.1038/nature05456 · Cited by 669 · see citing works
Self-citationTargeting senescent cells alleviates obesity-induced metabolic dysfunction
Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell · doi:10.1111/acel.12950 · Cited by 658 · see citing works
Adipose Tissue Dysfunction in Obesity
Blüher, M. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1192044 · Cited by 657 · see citing works
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
Hanks, S., Coleman, K., Reid, S., Plaja, A., Firth, H., Fitzpatrick, D., Kidd, A., Méhes, K., Nash, R., Robin, N. H., et al. (2004) · Nature Genetics · doi:10.1038/ng1449 · Cited by 627 · see citing works
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Xu, M., Palmer, A. K., Ding, H., Weivoda, M. M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., et al. (2015) · eLife · doi:10.7554/elife.12997 · Cited by 604 · see citing works
The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System
Daryabor, G., Atashzar, M. R., Kabelitz, D., Meri, S., & Kalantar, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01582 · Cited by 600 · see citing works
Accumulation of senescent cells in Mitotic tissue of aging primates
Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works
p16 <sup>INK4A</sup> is a robust <i>in vivo</i> biomarker of cellular aging in human skin
Ressler, S., Bartkova, J., Niederegger, H., Bartek, J., Scharffetter‐Kochanek, K., Jansen‐Dürr, P., & Wlaschek, M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00231.x · Cited by 557 · see citing works
Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation
Eguchi, K., Manabe, I., Tanaka, Y., Ohsugi, M., Kono, N., Ogata, F., Yagi, N., Ohto, U., Kimoto, M., Miyake, K., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.023 · Cited by 519 · see citing works
Liu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00489.x · Cited by 509 · see citing works
From pre-diabetes to diabetes: diagnosis, treatments and translational research
Khan, R., Chua, Z., Tan, J., Yang, Y., Liao, Z., & Zhao, Y. (2019) · Medicina · doi:10.3390/medicina55090546 · Cited by 484 · see citing works
Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes
Aguayo-Mazzucato, C., Andle, J., Lee, T. B., Midha, A., Talemal, L., Chipashvili, V., Hollister-Lock, J., van Deursen, J., Weir, G., & Bonner-Weir, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.006 · Cited by 469 · see citing works
Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
Bernadotte, A., Mikhelson, V. M., & Spivak, I. M. (2016) · Aging · doi:10.18632/aging.100871 · Cited by 466 · see citing works
Very Slow Turnover of β-Cells in Aged Adult Mice
Teta, M., Long, S. Y., Wartschow, L. M., Rankin, M. M., & Kushner, J. A. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2557 · Cited by 465 · see citing works
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M., & Kirkland, J. L. (2015) · Diabetes · doi:10.2337/db14-1820 · Cited by 423 · see citing works
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00305-3 · Cited by 420 · see citing works
Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
Burd, C. E., Sorrentino, J. A., Clark, K. S., Darr, D. B., Krishnamurthy, J., Deal, A. M., Bardeesy, N., Castrillon, D. H., Beach, D. H., & Sharpless, N. E. (2013) · Cell · doi:10.1016/j.cell.2012.12.010 · Cited by 419 · see citing works
Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes
Lytrivi, M., Castell, A., Poitout, V., & Cnop, M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.09.016 · Cited by 413 · see citing works
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
Baker, D. J., Perez-Terzic, C., Jin, F., Pitel, K. S., Niederländer, N. J., Jeganathan, K., Yamada, S., Reyes, S., Rowe, L., Hiddinga, H. J., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1744 · Cited by 408 · see citing works
Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V., Duffaut, C., Bonnafous, S., Blin‐Wakkach, C., Anty, R., Iannelli, A., Gugenheim, J., et al. (2012) · Diabetes · doi:10.2337/db11-1274 · Cited by 403 · see citing works
Georgakopoulou, E., Tsimaratou, K., Evangelou, K., Fernandez, M.-P., Zoumpourlis, V, Trougakos, I., Kletsas, D., Bartek, J., Serrano, M., & Gorgoulis, V. (2012) · Aging · doi:10.18632/aging.100527 · Cited by 390 · see citing works
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus
Petersen, K. F., & Shulman, G. I. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02554-7 · Cited by 390 · see citing works
Endoplasmic reticulum stress and pancreatic β-cell death
Fonseca, S. G., Gromada, J., & Urano, F. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.02.008 · Cited by 384 · see citing works
Chen, H., Gu, X., Su, I.-H., Bottino, R., Contreras, J. L., Tarakhovsky, A., & Kim, S. K. (2009) · Genes & Development · doi:10.1101/gad.1742509 · Cited by 366 · see citing works
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15318 · Cited by 363 · see citing works
Melk, A., Schmidt, B. M. W., Takeuchi, O., Sawitzki, B., Rayner, D. C., & Halloran, P. F. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00438.x · Cited by 362 · see citing works
Islet inflammation in type 2 diabetes and physiology
Eguchi, K., & Nagai, R. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88877 · Cited by 359 · see citing works
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
Thompson, P. J., Shah, A., Ntranos, V., Van Gool, F., Atkinson, M., & Bhushan, A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.021 · Cited by 353 · see citing works
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
Chini, C. C. S., Peclat, T. R., Warner, G. M., Kashyap, S., Espindola-Netto, J. M., de Oliveira, G. C., Gomez, L. S., Hogan, K. A., Tarragó, M. G., Puranik, A. S., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00298-z · Cited by 349 · see citing works
Formation of a human β-cell population within pancreatic islets is set early in life
Gregg, B. E., Moore, P. C., Demozay, D., Hall, B. A., Li, M., Husain, A., Wright, A. J., Atkinson, M. A., & Rhodes, C. J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1206 · Cited by 344 · see citing works
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Robbins, P. D., Jurk, D., Khosla, S., Kirkland, J. L., LeBrasseur, N. K., Miller, J. D., Passos, J. F., Pignolo, R. J., Tchkonia, T., & Niedernhofer, L. J. (2021) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-050120-105018 · Cited by 339 · see citing works
Self-citationCellular senescence: at the nexus between ageing and diabetes
Palmer, A. K., Gustafson, B., Kirkland, J. L., & Smith, U. (2019) · Diabetologia · doi:10.1007/s00125-019-4934-x · Cited by 337 · see citing works
Tai, H., Wang, Z., Gong, H., Han, X., Zhou, J., Wang, X., Wei, X., Ding, Y., Huang, N., Qin, J., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1247143 · Cited by 334 · see citing works
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
Yousefzadeh, M. J., Zhao, J., Bukata, C., Wade, E. A., McGowan, S. J., Angelini, L. A., Bank, M. P., Gurkar, A. U., McGuckian, C. A., Calubag, M. F., et al. (2020) · Aging Cell · doi:10.1111/acel.13094 · Cited by 331 · see citing works
Self-citationDepletion of fat-resident Treg cells prevents age-associated insulin resistance
Bapat, S. P., Suh, J. M., Fang, S., Liu, S., Zhang, K. Y., Cheng, A., Zhou, C., Liang, Y., Leblanc, M., Liddle, C., et al. (2015) · Nature · doi:10.1038/nature16151 · Cited by 325 · see citing works
Sadaie, M., Salama, R., Carroll, T., Tomimatsu, K., Chandra, T., Young, A. R. J., Narita, M., Pérez-Mancera, P. A., Bennett, D. C., Chong, H., et al. (2013) · Genes & Development · doi:10.1101/gad.217281.113 · Cited by 323 · see citing works
Pluquet, O., Pourtier, A., & Abbadie, C. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00334.2014 · Cited by 305 · see citing works
Sone, H., & Kagawa, Y. (2005) · Diabetologia · doi:10.1007/s00125-004-1605-2 · Cited by 286 · see citing works
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy
Binet, F., Cagnone, G., Crespo-Garcia, S., Hata, M., Neault, M., Dejda, A., Wilson, A. M., Buscarlet, M., Mawambo, G. T., Howard, J. P., et al. (2020) · Science · doi:10.1126/science.aay5356 · Cited by 283 · see citing works
Senescent cells develop a parp-1 and nuclear factor-κB-associated secretome (PNAS).
Ohanna, M., Giuliano, S., Bonet, C., Imbert, V., Hofman, V., Zangari, J., Bille, K., Robert, C., Bressac-de Paillerets, B., Hofman, P., et al. (2011) · Genes & Development · doi:10.1101/gad.625811 · Cited by 267 · see citing works
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
Schafer, M. J., White, T. A., Evans, G., Tonne, J. M., Verzosa, G. C., Stout, M. B., Mazula, D. L., Palmer, A. K., Baker, D. J., Jensen, M. D., et al. (2016) · Diabetes · doi:10.2337/db15-0291 · Cited by 267 · see citing works
A Senescence-Centric View of Aging: Implications for Longevity and Disease
Borghesan, M., Hoogaars, W. M. H., Varela-Eirin, M., Talma, N., & Demaria, M. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.07.002 · Cited by 267 · see citing works
Islet-associated macrophages in type 2 diabetes
Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2009) · Diabetologia · doi:10.1007/s00125-009-1410-z · Cited by 240 · see citing works
Liu, Y., Drozdov, I. A., Shroff, R. C., Beltran, L. E., & Shanahan, C. M. (2013) · Circulation Research · doi:10.1161/circresaha.111.300543 · Cited by 238 · see citing works
Do DNA Double-Strand Breaks Drive Aging?
White, R. R., & Vijg, J. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.004 · Cited by 232 · see citing works
Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction
Sun, K., Halberg, N., Khan, M., Magalang, U. J., & Scherer, P. E. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00951-12 · Cited by 231 · see citing works
James, E. L., Michalek, R. D., Pitiyage, G. N., de Castro, A. M., Vignola, K. S., Jones, J., Mohney, R. P., Karoly, E. D., Prime, S. S., & Parkinson, E. K. (2015) · Journal of Proteome Research · doi:10.1021/pr501221g · Cited by 231 · see citing works
Diabetes and Aging: unique considerations and goals of care
Kalyani, R. R., Golden, S. H., & Cefalu, W. T. (2017) · Diabetes Care · doi:10.2337/dci17-0005 · Cited by 226 · see citing works
Imanishi, T., Hano, T., Sawamura, T., & Nishio, I. (2004) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2004.04022.x · Cited by 221 · see citing works
Mortuza, R., Chen, S., Feng, B., Sen, S., & Chakrabarti, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054514 · Cited by 205 · see citing works
β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance
Aguayo-Mazzucato, C., van Haaren, M., Mruk, M., Lee, T. B., Crawford, C., Hollister-Lock, J., Sullivan, B. A., Johnson, J. W., Ebrahimi, A., Dreyfuss, J. M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.015 · Cited by 198 · see citing works
Kennedy, D. J., Kuchibhotla, S., Westfall, K. M., Silverstein, R. L., Morton, R. E., & Febbraio, M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq360 · Cited by 197 · see citing works
Targeted genes and interacting proteins of hypoxia inducible factor-1.
Liu, W., Shen, S. M., Zhao, X., & Chen, G. Q. (2012) · Europe PMC (PubMed Central) · Cited by 187 · see citing works
The Signaling of Cellular Senescence in Diabetic Nephropathy
Xiong, Y., & Zhou, L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7495629 · Cited by 185 · see citing works
Crespo-Garcia, S., Tsuruda, P. R., Dejda, A., Ryan, R. D., Fournier, F., Chaney, S. Y., Pilon, F., Dogan, T., Cagnone, G., Patel, P., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.01.011 · Cited by 182 · see citing works
Bent, E. H., Gilbert, L. A., & Hemann, M. T. (2016) · Genes & Development · doi:10.1101/gad.284851.116 · Cited by 179 · see citing works
Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease
Gregg, S. Q., Robinson, A. R., & Niedernhofer, L. J. (2011) · DNA Repair · doi:10.1016/j.dnarep.2011.04.026 · Cited by 175 · see citing works
Self-citationHasegawa, Y., Saito, T., Ogihara, T., Ishigaki, Y., Yamada, T., Imai, J., Uno, K., Gao, J., Kaneko, K., Shimosawa, T., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.054346 · Cited by 168 · see citing works
Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions
Pezze, P. D., Nelson, G., Otten, E. G., Korolchuk, V. I., Kirkwood, T. B. L., von Zglinicki, T., & Shanley, D. P. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003728 · Cited by 162 · see citing works
Butcher, M. J., Hallinger, D. R., Garcia, E., Machida, Y., Chakrabarti, S., Nadler, J. L., Galkina, E., & Imai, Y. (2014) · Diabetologia · doi:10.1007/s00125-013-3116-5 · Cited by 161 · see citing works
Cellular Senescence: What, Why, and How.
Regulski, M. J. (2017) · PubMed · Cited by 157 · see citing works
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.04.007 · Cited by 155 · see citing works
Self-citationKitada, K., Nakano, D., Ohsaki, H., Hitomi, H., Minamino, T., Yatabe, J., Felder, R. A., Mori, H., Masaki, T., Kobori, H., et al. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.05.010 · Cited by 151 · see citing works
Chen, K., Dai, H., Yuan, J., Chen, J., Lin, L., Zhang, W., Wang, L., Zhang, J., Li, K., & He, Y. (2018) · Cell Death & Disease · doi:10.1038/s41419-017-0127-z · Cited by 150 · see citing works
The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders
Liu, Z., Wu, K. K.-L., Jiang, X. X., Xu, A., & Cheng, K. K. Y. (2020) · Clinical Science · doi:10.1042/cs20190966 · Cited by 139 · see citing works
Surendar, J., Frohberger, S. J., Indulekha, K., Schmitt, V., Stamminger, W., Neumann, A., Wilhelm, C., Hoerauf, A. M., & Hübner, M. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02555 · Cited by 121 · see citing works
Chkhotua, A. B., Gabusi, E., Altimari, A., D’Errico, A., Yakubovich, M., Vienken, J., Stefoni, S., Chieco, P., Yussim, A., & Grigioni, W. F. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00363-9 · Cited by 120 · see citing works
Turenne, G. A., Paul, P., Laflair, L., & Price, B. D. (2001) · Oncogene · doi:10.1038/sj.onc.1204665 · Cited by 120 · see citing works
<scp>NF</scp>‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases
Kanigur Sultuybek, G., Soydas, T., & Yenmis, G. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13073 · Cited by 119 · see citing works
Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6
Liu, R., Liu, H., Ha, Y., Tilton, R. G., & Zhang, W. (2014) · BioMed Research International · doi:10.1155/2014/902842 · Cited by 118 · see citing works
Type 2 diabetes is associated with the accumulation of senescent T cells
Lau, E. Y. M., Carroll, E. C., Callender, L. A., Hood, G., Berryman, V., Pattrick, M., Finer, S., Hitman, G. A., Ackland, G. L., & Henson, S. M. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13344 · Cited by 116 · see citing works
Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes
Fyhrquist, F., Tiitu, A., Saijonmaa, O., Forsblom, C. M., Groop, P., & on behalf of the FinnDiane Study Group (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02139.x · Cited by 112 · see citing works
Caveolin-1, cellular senescence and age-related diseases
Zou, H., Stoppani, E., Volonte, D., & Galbiati, F. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.11.001 · Cited by 112 · see citing works
Barinda, A. J., Ikeda, K., Nugroho, D. B., Wardhana, D. A., Sasaki, N., Honda, S., Urata, R., Matoba, S., Hirata, K., & Emoto, N. (2020) · Nature Communications · doi:10.1038/s41467-020-14387-w · Cited by 112 · see citing works
Sharma, M., Boytard, L., Hadi, T., Koelwyn, G. J., Simon, R., Ouimet, M. I., Seifert, L., Spiro, W., Yan, B., Hutchison, S. B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62272-9 · Cited by 105 · see citing works
T-cell senescence contributes to abnormal glucose homeostasis in humans and mice
Yi, H., Kim, S. Y., Kim, J. T., Lee, Y., Moon, J. S., Kim, M., Kang, Y. E., Joung, K. H., Lee, J. H., Kim, H. J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1494-4 · Cited by 102 · see citing works
Functional changes in beta cells during ageing and senescence
Aguayo‐Mazzucato, C. (2020) · Diabetologia · doi:10.1007/s00125-020-05185-6 · Cited by 101 · see citing works
Short Telomeres Compromise β-Cell Signaling and Survival
Guo, N., Parry, E. M., Li, L.-S., Kembou, F., Lauder, N., Hussain, M. A., Berggren, P.-O., & Armanios, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017858 · Cited by 100 · see citing works
Accelerated Kidney Aging in Diabetes Mellitus
Guo, J., Zheng, H., Zhang, W., Lou, W., Xia, C., Han, X. T., Huang, W. J., Zhang, F., Wang, Y., & Liu, W. J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1234059 · Cited by 99 · see citing works
An update on immune dysregulation in obesity‐related insulin resistance
Daryabor, G., Kabelitz, D., & Kalantar, K. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12747 · Cited by 96 · see citing works
Molecular and Cell Biology of Replicative SenescencePreprint
Dimri, G. P., & Campisi, J. (1994) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1994.059.01.010 · Cited by 93 · see citing works
Chuang, H., Sheu, W. H., Lin, Y.-T., Tsai, C.-Y., Yang, C. Y., Cheng, Y.-J., Huang, P. Y., Li, J.-P., Chiu, L.-L., Wang, X., et al. (2014) · Nature Communications · doi:10.1038/ncomms5602 · Cited by 88 · see citing works
ATF6α regulates morphological changes associated with senescence in human fibroblasts
Druelle, C., Drullion, C., Deslé, J., Martin, N., Saas, L., Cormenier, J., Malaquin, N., Huot, L., Slomianny, C., Bouali, F., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11505 · Cited by 87 · see citing works
Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1
Shosha, E., Xu, Z., Narayanan, S. P., Lemtalsi, T., Fouda, A. Y., Rojas, M., Ji, X., Fulton, D. J., Caldwell, R. W., & Caldwell, R. B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041215 · Cited by 82 · see citing works
Matsui‐Hirai, H., Hayashi, T., Yamamoto, S., Ina, K., Maeda, M., Kotani, H., Iguchi, A., Ignarro, L. J., & Hattori, Y. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.177584 · Cited by 79 · see citing works
Galle-Treger, L., Sankaranarayanan, I., Hurrell, B. P., Howard, E. D., Lo, R., Maazi, H., Lewis, G. M., Banie, H., Epstein, A. L., Hu, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08449-x · Cited by 75 · see citing works
Zhang, X., Chen, X., Wu, D., Liu, W., Wang, J., Feng, Z., Cai, G., Fu, B., Hong, Q., & Du, J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005070776 · Cited by 73 · see citing works
NOX2-Induced Activation of Arginase and Diabetes-Induced Retinal Endothelial Cell Senescence
Rojas, M., Lemtalsi, T., Toque, H. A., Xu, Z., Fulton, D. J., Caldwell, R. W., & Caldwell, R. B. (2017) · Antioxidants · doi:10.3390/antiox6020043 · Cited by 73 · see citing works
Zhao, X.-Y., Zhou, L., Chen, Z., Ji, Y., Peng, X., Qi, L., Li, S., & Lin, J. D. (2020) · Science Advances · doi:10.1126/sciadv.aay6191 · Cited by 71 · see citing works
Thounaojam, M. C., Jadeja, R. N., Warren, M., Powell, F. L., Raju, R. P., Gutsaeva, D. R., Khurana, S., Martin, P. M., & Bartoli, M. (2019) · Antioxidants · doi:10.3390/antiox8090328 · Cited by 64 · see citing works
Adiposity‐Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans
Ehrhardt, N., Cui, J., Dağdeviren, S., Saengnipanthkul, S., Goodridge, H. S., Kim, J. K., Lantier, L., Guo, X., Chen, Y. I., Raffel, L. J., et al. (2019) · Obesity · doi:10.1002/oby.22418 · Cited by 63 · see citing works
Aging and stress induced β cell senescence and its implication in diabetes development
Li, N., Liu, F., Yang, P. C., Xiong, F., Yu, Q., Li, J., Zhou, Z., Zhang, S., & Wang, C. (2019) · Aging · doi:10.18632/aging.102432 · Cited by 62 · see citing works
Sampson, M., & Hughes, D. A. (2006) · Diabetologia · doi:10.1007/s00125-006-0322-4 · Cited by 59 · see citing works
Liu, J., Chen, S., Biswas, S., Nagrani, N., Chu, Y., Chakrabarti, S., & Feng, B. (2020) · Physiological Reports · doi:10.14814/phy2.14331 · Cited by 54 · see citing works
β-Cell Telomere Attrition in Diabetes: Inverse Correlation Between HbA1c and Telomere Length
Tamura, Y., Izumiyama‐Shimomura, N., Kimbara, Y., Nakamura, K., Ishikawa, N., Aida, J., Chiba, Y., Mori, S., Arai, T., Aizawa, T., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1222 · Cited by 53 · see citing works
McDonnell, W. J., Koethe, J., Mallal, S., Pilkinton, M. A., Kirabo, A., Ameka, M. K., Cottam, M., Hasty, A., & Kennedy, A. (2018) · Diabetes · doi:10.2337/db18-0040 · Cited by 48 · see citing works
Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes
Chan, J. Y., Lee, K., Maxwell, E. L., Liang, C., & Laybutt, D. R. (2019) · Diabetologia · doi:10.1007/s00125-019-4844-y · Cited by 45 · see citing works
Islet autoimmunity in phenotypic type 2 diabetes patients
Brooks‐Worrell, B., Narla, R. R., & Palmer, J. P. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12167 · Cited by 41 · see citing works
DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
Shafiei-Jahani, P., Hurrell, B. P., Galle-Treger, L., Helou, D. G., Howard, E. D., Painter, J. D., Lo, R., Lewis, G. M., Soroosh, P., & Akbari, O. (2020) · Nature Communications · doi:10.1038/s41467-020-18601-7 · Cited by 35 · see citing works
Zhao, R., He, Q., Sha, S., Song, J., Qin, J., Liu, P., Sun, Y., Sun, L., Hou, X., & Chen, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01644 · Cited by 23 · see citing works
Zhang, T., Tian, F., Wang, J., et al. (2015) · Cell Stress and Chaperones · doi:10.1007/s12192-015-0601-4 · Cited by 22 · see citing works
Yamada, T., KAMIYA, M., HIGUCHI, M., & NAKANISHI, N. (2018) · Journal of Veterinary Medical Science · doi:10.1292/jvms.18-0324 · Cited by 21 · see citing works
Parvizi, M., Ryan, Z. C., Ebtehaj, S., Arendt, B. K., & Lanza, I. R. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165983 · Cited by 19 · see citing works
Cui, X., Lin, X., Zhong, J., Li, S., He, J., Ni, Y., Zhan, J., & Liu, Y. (2020) · Aging Medicine · doi:10.1002/agm2.12106 · Cited by 18 · see citing works
Li, R., Huang, J., Yu, Y., & Yang, Y. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00260 · Cited by 15 · see citing works
Cucak, H., Vistisen, D., Witte, D. R., Philipsen, A., & Rosendahl, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107140 · Cited by 13 · see citing works
Understanding Diabetic Induction of Cellular Senescence: A Concise Review.
Regulski, M. J. (2018) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [48]48. Ressler S, Bartkova J, Niederegger H, et al. p16INK4A is a ro- bust in vivo biomarker of cellular aging in human skin. Aging Cell. 2006;5(5):379-389.
- [65]65. Maedler K, Sergeev P, Ris F, et al. Glucose-induced beta cell pro- duction of IL-1beta contributes to glucotoxicity in human pan- creatic islets. J Clin Invest. 2002;110(6):851-860.
- [84]84. Aguayo-Mazzucato C, Andle J, Lee TB Jr, et al. Acceleration of β cell aging determines diabetes and senolysis improves disease outcomes. Cell Metab. 2019;30(1):129-142.e4.
Cited by
Sorted by citations
Telomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754 · see citing works
Context‐dependent roles of cellular senescence in normal, aged, and disease states
Moiseeva, V., Cisneros, A., Cobos, A. C., Tarrega, A. B., Oñate, C. S., Perdiguero, E., Serrano, A. L., & Muñoz‐Cánoves, P. (2023) · The FEBS Journal · doi:10.1111/febs.16573 · Cited by 34 · see citing works
- Authors
- Narasimhan, A., Flores, R. R., Robbins, P. D., & Niedernhofer, L. J.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Niedernhofer, Laura J
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2021-08-07
- Volume
- 162
- Issue
- 10
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC8386762
- OpenAlex
- W3188031952
- Cited by
- 133
- References
- 151
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 36 · 2023: 21 · 2022: 12 · 2021: 3
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P01 R01 AG063543, R01 AG043376, U19 AG056278, P01 AG062413)
- National Institute on Aging
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, type 2 diabetes, senescence-associated secretory phenotype, beta-cell dysfunction, insulin resistance, adipose tissue dysfunction, aging, obesity, hyperglycemia, diabetes complications, inflammation
- MeSH terms
- Senescence-Associated Secretory Phenotype, Adipose Tissue, Aging, Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Diabetic Retinopathy, Disease Models, Animal, Humans, Hyperglycemia, Immune System, Inflammation, Insulin, Insulin Resistance, Obesity, Phenotype, Cellular Senescence, Insulin-Secreting Cells, Mice, TOR Serine-Threonine Kinases
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