The DOI matches its Crossref record; 157 of the 158 references it cites were found in a registry or an index.
Liver inflammation and fibrosis
Open accessAbstract
Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and insulin resistance. Hepatic steatosis may be benign or progress to hepatocyte injury and the initiation of inflammation, which activates immune cells. While Kupffer cells are the resident macrophage in the liver, inflammatory cells such as infiltrating macrophages, T lymphocytes, neutrophils, and DCs all contribute to liver inflammation. The inflammatory cells activate hepatic stellate cells, which are the major source of myofibroblasts in the liver. Here we review the initiation of inflammation in the liver, the liver inflammatory cells, and their crosstalk with myofibroblasts.
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“A key event in liver fibrogenesis is the activation of quiescent HSCs, which differentiate into myofibroblasts and secrete large amounts of collagen and profibrosis factors.( 71 )”
From The Emerging Role of B Cells in the Pathogenesis of NAFLD (2021) · cites this paper as [71]
In the citing paper
“A key event in liver fibrogenesis is the activation of quiescent HSCs, which differentiate into myofibroblasts and secrete large amounts of collagen and profibrosis factors.( 71 )”
From The Emerging Role of B Cells in the Pathogenesis of NAFLD (2021) · cites this paper as [71]
In the citing paper
“Hepatic stellate cells (HSCs) play pivotal roles in the pathological development of liver fibrosis27.”
From SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis (2020) · cites this paper as [27]
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Citations
Cites
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Cited by
Sorted by citations
Inflammatory mechanisms linking obesity and metabolic disease
Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212
“…discuss the close connection between obesity, diabetes, hepatic inflammation, and the development of nonalcoholic fatty liver disease (NAFLD), which can progress to nonalcoholic steatohepatitis (NASH) and eventually frank cirrhosis due to sequential activation of inflammation and fibrosis (10).”
BackgroundMechanisms and disease consequences of nonalcoholic fatty liver disease
Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002
“Recent articles have reviewed general pathways of fibrosis and its degradation in the liver (Koyama and Brenner, 2017; Tsuchida and Friedman, 2017), and here we focus primarily on NASH-specific mechanisms.”
BackgroundLiver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
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Triggering and resolution of inflammation in NASH
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Western Diet and the Immune System: An Inflammatory Connection
Christ, A., Lauterbach, M., & Latz, E. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.020 · Cited by 907
Metadata
- Authors
- Koyama, Y., & Brenner, D. A.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Brenner, David A.
- Venue
- Journal of Clinical Investigation
- Published
- 2017-01-03
- Volume
- 127
- Issue
- 1
- Pages
- 55-64
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC5199698
- OpenAlex
- W2562949639
- Cited by
- 1,295
- References
- 158
- Citations by year
- 2026: 139 · 2025: 162 · 2024: 159 · 2023: 171 · 2022: 173 · 2021: 177 · 2020: 151 · 2019: 85 · 2018: 63 · 2017: 13
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (ES010337, AA011999)
- National Institute on Alcohol Abuse and Alcoholism (U01AA021856, P50AA011999)
- National Institute of Environmental Health Sciences (P42ES010337)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Keywords
- liver inflammation, liver fibrosis, liver cirrhosis, hepatic steatosis, Kupffer cells, hepatic stellate cells, myofibroblasts, immune cell crosstalk, T cells, neutrophils, dendritic cells, metabolic syndrome, insulin resistance
- MeSH terms
- Animals, Dendritic Cells, Hepatitis, Humans, Inflammation, Kupffer Cells, Liver, Liver Cirrhosis, Neutrophils, T-Lymphocytes, Hepatic Stellate Cells, Myofibroblasts
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