Brenner, David A.

Liver fibrosis

Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 4,958

Molecular and cellular mechanisms of liver fibrosis and its regression

Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 2,024

TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine

Liver physiology and pathologyImmune Response and Inflammation

Cited by 1,942

The gut-liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 1,480

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

Lemasters, J. J., Nieminen, A.-L., Qian, T., Trost, L. C., Elmore, S. P., Nishimura, Y., Crowe, R. A., Cascio, W. E., Bradham, C. A., Brenner, D. A., et al. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,387

Liver inflammation and fibrosis

Koyama, Y., & Brenner, D. A. (2017) · Journal of Clinical Investigation

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 1,295

Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

Loomba, R., Seguritan, V., Li, W., Long, T., Klitgord, N., Bhatt, A., Dulai, P. S., Caussy, C., Bettencourt, R., Highlander, S. K., et al. (2017) · Cell Metabolism

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 1,123

Interactions Between the Intestinal Microbiome and Liver Diseases

Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 971

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 805

Enteric dysbiosis associated with a mouse model of alcoholic liver disease

Yan, A. W., Fouts, D. E., Brandl, J., Stärkel, P., Torralba, M., Schott, E., Tsukamoto, H., Nelson, K. E., Brenner, D. A., & Schnabl, B. (2011) · Hepatology

Gut microbiota and healthAlcohol Consumption and Health Effects

Cited by 791

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 741

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., et al. (2015) · Nature Medicine

Adipose Tissue and MetabolismDrug Transport and Resistance Mechanisms

Cited by 738

Toll‐like receptors and adaptor molecules in liver disease: Update†

Seki, E., & Brenner, D. A. (2008) · Hepatology

Immune Response and InflammationLiver physiology and pathology

Cited by 722

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

Meng, F., Wang, K., Aoyama, T., Grivennikov, S. I., Paik, Y., Scholten, D., Cong, M., Iwaisako, K., Liu, X., Zhang, M., et al. (2012) · Gastroenterology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 711

Toll-Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells

Paik, Y.-H., Schwabe, R. F., Bataller, R., Russo, M. P., Jobin, C., & Brenner, D. A. (2003) · Hepatology

Immune Response and InflammationLiver physiology and pathology

Cited by 651

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine

Circadian rhythm and melatoninMetabolism, Diabetes, and Cancer

Cited by 567

Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials: Hepatology

Noureddin, M., Lam, J., Peterson, M. R., Middleton, M., Hamilton, G., Le, T.-A., Bettencourt, R., Changchien, C., Brenner, D. A., Sirlin, C., et al. (2013) · Hepatology

Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and Applications

Cited by 550

Origin of myofibroblasts in the fibrotic liver in mice

Iwaisako, K., Jiang, C., Zhang, M., Cong, M., Moore-Morris, T. J., Park, T. J., Liu, X., Xu, J., Wang, P., Paik, Y.-H., et al. (2014) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 535

CCR1 and CCR5 promote hepatic fibrosis in mice

Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation

Liver physiology and pathologyChemokine receptors and signaling

Cited by 431

Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-α and Interleukin-6

Li, Y., Schwabe, R. F., DeVries-Seimon, T., Yao, P. M., Gerbod-Giannone, M.-C., Tall, A. R., Davis, R. J., Flavell, R., Brenner, D. A., & Tabas, I. (2005) · Journal of Biological Chemistry

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 421

The role of TGFβ1 in initiating hepatic stellate cell activation in vivo

Hellerbrand, C., Stefanovic, B., Giordano, F., Burchardt, E. R., & Brenner, D. A. (1999) · Journal of Hepatology

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 393

Role of Mitochondrial Inner Membrane Permeabilization in Necrotic Cell Death, Apoptosis, and Autophagy

Lemasters, J. J., Qian, T., He, L., Kim, J.-S., Elmore, S. P., Cascio, W. E., & Brenner, D. A. (2002) · Antioxidants & Redox Signaling

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 377

A Gut Microbiome Signature for Cirrhosis Due to Nonalcoholic Fatty Liver Disease

Caussy, C., Tripathi, A., Humphrey, G., Bassirian, S., Singh, S., Faulkner, C., Bettencourt, R., Rizo, E., Richards, L., Xu, Z. Z., et al. (2019) · Nature Communications

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 338

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

Aoyama, T., Paik, Y.-H., Watanabe, S., Laleu, B., Gaggini, F., Fioraso-Cartier, L., Molango, S., Heitz, F., Merlot, C., Szyndralewiez, C., et al. (2012) · Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 336