The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice
Open accessAbstract
Diabetes is associated with increased prevalence, severity, and progression of periodontal disease. To test the hypothesis that activation of RAGE (Receptor for Advanced Glycation End products) contributes to the pathogenesis of diabetes-associated periodontitis, we treated diabetic mice, infected with the human periodontal pathogen Porphyromonas gingivalis, with soluble RAGE (sRAGE). sRAGE is the extracellular domain of the receptor, which binds ligand and blocks interaction with, and activation of, cell-surface RAGE. Blockade of RAGE diminished alveolar bone loss in a dose-dependent manner. Moreover, we noted decreased generation of the proinflammatory cytokines TNF-alpha and IL-6 in gingival tissue, as well as decreased levels of matrix metalloproteinases. Gingival AGEs were also reduced in mice treated with sRAGE, paralleling the observed suppression in alveolar bone loss. These findings link RAGE and exaggerated inflammatory responses to the pathogenesis of destructive periodontal disease in diabetes.
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Cites
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Self-citationPeriodontal Disease: The sixth complication of diabetes mellitus
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Cited by
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
Hajishengallis, G., & Chavakis, T. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00488-6 · Cited by 1,871
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Self-citationDiabetes and Its Effect on Bone and Fracture Healing
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Receptor for AGE (RAGE): Signaling mechanisms in the pathogenesis of diabetes and its complications
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Metadata
- Authors
- Lalla, E., Lamster, I. B., Feit, M., Huang, L., Spessot, A., Qu, W., Kislinger, T., Lu, Y., Stern, D. M., & Schmidt, A. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2000-04-15
- Volume
- 105
- Issue
- 8
- Pages
- 1117-1124
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2061689566
- Cited by
- 375
- References
- 54
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lalla, E., Lamster, I. B., Feit, M., Huang, L., Spessot, A., Qu, W., Kislinger, T., Lu, Y., Stern, D. M., & Schmidt, A. M. (2000). Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci8942
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