Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

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5. Peripherally administered desacetyl α-MSH and α-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression
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6. Mutational analysis of the melanocortin-4 receptor (MC4R) gene in children with premature pubarche and adolescent girls with hyperandrogenism
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7. Neuroendocrine Control of Energy Stores
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8. Genetic Syndromes Associated with Obesity
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9. Genetic Syndromes Associated with Obesity
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10. Strategies for Studying Complex Genetic Traits
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11. ENPP1, premier exemple d’un déterminant génétique commun à l’obésité et au diabète de type 2
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12. The proof of the pudding is in the eating: Editorial Focus on “Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4-receptor knockout mice”
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13. Regulation der Nahrungsaufnahme: Physiologische Mechanismen und klinische Relevanz
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14. Neuropeptide Regulation of Appetite and Reproduction
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15. Leptin and Other Appetite Suppressants
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16. High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
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17. Dual Activation of MC3R and MC4R Drives Weight Loss and Reduces Food Intake in Obese Primates
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18. Motivational dysregulation with melanocortin 4 receptor haploinsufficiency
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19. Brain POMC Neurons: Comparative Aspects of Anatomy, Peptide Processing and Function
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20. Gastric Mucosal Damage Following Repeat Administration of Melanocortin Subtype-4 Receptor Ligands to Fischer 344 Rats
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21. Inactivating Melanocortin 4 Receptor Mutations and Human Obesity
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22. Association of MC4R codon 42 polymorphism with obese/diabetic ethnic Kashmiri population
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24. Molecular Genetics of Obesity Syndrome
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25. Genetic Aspects of Obesity.
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26. Nutrient-gene interactions contributing to the development of obesity
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27. Hypothalamic Obesity and Wasting Syndromes
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28. Obesity Syndromes
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29. Monogenic Obesity
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30. Appetite Regulation and Thermogenesis
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31. Melanocortin receptors in GtoPdb v.2023.1
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32. The Interaction Between Genetic Variation and Exercise and Physical Activity in the Determination of Body Composition and Obesity Status
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33. Mouse Models to Study the Effect of Natural Products on Obesity-Associated NAFLD/NASH
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34. Childhood Obesity: Epidemiological and Clinical aspects
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35. Neuroregulatory Peptides of Central Nervous System Origin
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36. Molecular Mechanisms Involved in the Regulation of Food Intake
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37. Optimized purification and characterization of expressed hMC4R-TM2
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38. Update on Essential Hypertension
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39. MC4R Mutation in Early-onset Severe Childhood Obesity—Genotype–phenotype Correlation
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40. Efficient purification of human transmembrane protein, mutant hMC4R TM2
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41. The infundibular peptidergic neurons and glia cells in overeating, obesity, and diabetes
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42. Obesity treatment effect in danish children and adolescents carrying melanocortin-4 receptor mutations
    Cæcilie Trier, Mette Hollensted, Theresia Maria Schnurr, Lund MAV, Nielsen TRH, Rui G, Ehm Astrid Andersson Galijatovic, Mathilde Svendstrup, Dorthe Sadowa Bille, Anette P. Gjesing et al. · 2021 · Yearbook of pediatric endocrinology
43. Prevention and Treatment of Obesity in Children
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44. Obesity-related mutations of leptin and melanocortin receptors
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45. Understanding and Managing Obesity
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46. AgRP, physiological role of an inverse agonist
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47. Obésité : d’un syndrome monogénique exceptionnel aux interactions entre gènes multiples et environnement nutritionnel
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48. Regulation of Body Weight by Proopiomelanocortin Peptides in Humans: Lessons from the Nelson Syndrome
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49. Optimization of the experimental conditions for structural studies of the second transmembrane domain from human wild-type & mutant melanocortin-4 receptor
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50. The Genetic Contribution to Obesity
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51. The role of S6K1 in development and maintenance of nutrient homeostasis
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52. The Role of Lateral Hypothalamic Neuropeptides in Drug Addiction and Feeding Behavior
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53. Obesidad: interrelación genética ambiental
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54. Gastric emptying in humans; carbohydrate ingestion, gastrointestinal hormones and genetic variation
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55. Génétique de l'obésité humaine
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56. Genetic aspects of human obesity: a review.
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57. Candidate genes for obesity and related phenotypes
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58. Human melanocortin-3 receptor: structure-function relationship of DPLIY motif and helix 8 and biased signaling
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59. High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
    Conor J Howard, Nathan S. Abell, Beatriz A. Osuna, Eric M. Jones, Leon Y Chan, Henry Chan, Dean R. Artis, Jonathan B Asfaha, Joshua S. Bloom, Aaron R. Cooper et al. · 2025 · eLife
60. Pathogenic variation in insulin resistance genes is common in polycystic ovary syndrome (PCOS): a strategy for causal gene discovery using whole-exome sequencing (WES) in complex traits
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61. The genetic associations of rhegmatogenous retinal detachment and ectopia lentis
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62. Obesity
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63. Leptin and Other Appetite Suppressants
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64. ESTUDIO DE LOS MECANISMOS PATOGÉNICOS DE LA HEPATITIS C Y SU RELACIÓN CON EL DESARROLLO DE ESTEATOSIS. EFECTO DE UN TRATAMIENTO ANTIOXIDANTE CON FLAVONOIDES
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65. Molecular Genetics of Susceptibility to Coronary Heart Disease
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66. Most of rare missense alleles in humans are deleterious: implications for evolution of complex disease and association studies
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67. Le récepteur 4 aux mélanocortines, un paradigme de la génétique de l'obésité
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68. Efeito das variações alélicas no gene do receptor tipo 4 de melanocortina sobre o comportamento alimentar em crianças e adolescentes obesos
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71. The Neurogenetics of Energy Balance
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73. On the Molecular Pharmacology of the Melanocortin-4 Receptor
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74. Parks and Obesity in Rural and Urban Nebraska
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77. Beyond calories: Genetic determinants of eating, satiety and metabolism underlying obesity
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83. The Melanocortin System: Structure Activity Relationships of Alpha-N-Methylated MT-II Analogues and Mutation Studies of Human Melanocortin Receptor Subtypes 1 and 4
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84. The neural basis of estradiol conditioned taste aversion learning and estradiol anorexia
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85. Kyoto University graduate school of medicine: tradition and modernity harmonized
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87. MELANOCORTIN-4 RECEPTOR (MC4R) VARIANTS AND MEASURES OF ADIPOSITY IN THE GENERAL POPULATION
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88. O tratamento com leptina por 7 e 28 dias altera a função e a morfologia renal de ratos.
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89. Polymorphic analysis of MC4R gene in ethnic Kashmiri population with type 2 diabetes
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90. Molekulare Charakterisierung an der hypothalamischen Appetitregulation beteiligter Rezeptoren
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91. Identification of quantitative trait loci linked markers and characterization of positional candidate genes for beef marbling in Wagyu x Limousin F2 crosses
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92. Obesity
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93. Molekulare Grundlagen altersspezifischer Erkrankungen des Endokriniums
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94. Behavioral phenotyping meal patterns in mus musculus: validation, testing and application
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95. Human melanocortin-4 receptor: structure-function relationship of transmembrane domain 3 and biased signaling
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96. Analyse génotypique de gènes de susceptibilité à l'obésité au sein d'une cohorte de travailleurs forestiers de la compagnie Abitibi Consolotidated de Saint-Félicien /
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97. Genetics of obesity in Hong Kong Chinese : a candidate gene approach focusing on the melanocortin-4 receptor and adiponectin
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98. Genetische Mechanismen der Gewichtsregulation: genomweite Ansätze und Kandidatengenstudien
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99. Nutritional regulation of central fat mass and obesity-associated (FTO) expression, and its association with the central melanocortin signaling in the regulation of energy homeostasis
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100. Association analysis of MC1R, MC4R and AGRP in beef cattle
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