Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

Untitled work

(2000) · PubMed · Cited by 13,173

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Akram, D. S., Astrup, A. V., Atinmo, T., Boissin, J.-L., Bray, G. A., Carroll, K. N., Chitson, P., Chen, C., Dietz, W. H., Hill, J. O., et al. (2000) · Research at the University of Copenhagen (University of Copenhagen) · Cited by 12,945

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Stunkard, A. J., & Messick, S. (1985) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(85)90010-8 · Cited by 4,687

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Baecke, J. A. H., BUREMA, J., & Frijters, J. E. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.5.936 · Cited by 3,950

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The Obesogenic Environment: Epigenetic Modifications in Placental Melanocortin 4 Receptor Gene Connected to Gestational Diabetes and Smoking

Franzago, M., Porreca, A., D’Ardes, M., Nicola, M. D., Tizio, L. D., Liberati, M., Stuppia, L., & Vitacolonna, E. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.879526 · Cited by 11

Reguladores neuroendocrinos y gastrointestinales del apetito y la saciedad

Calzada‐León, R., Altamirano-Bustamante, N. F., & Ruiz-Reyes, M. D. L. L. (2008) · Boletín Médico del Hospital Infantil de México · Cited by 11

α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK

Møller, C. L., Kjøbsted, R., Enriori, P. J., Jensen, T. E., Garcia‐Rudaz, C., Litwak, S. A., Raun, K., Wojtaszewski, J. F. P., Wulff, B. S., & Cowley, M. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157027 · Cited by 12

Single-Minded View of Melanocortin Signaling in Energy Homeostasis

Baskin, D. G. (2006) · Endocrinology · doi:10.1210/en.2006-0807 · Cited by 11

Nutrient-gene interactions in the control of obesity

Verdich, C., & Sørensen, T. I. A. (2004) · Elsevier eBooks · doi:10.1533/9781855739017.2.223 · Cited by 11

Myo-Inositol Supplementation in Suckling Rats Protects against Adverse Programming Outcomes on Hypothalamic Structure Caused by Mild Gestational Calorie Restriction, Partially Comparable to Leptin Effects

Castillo, P., Palou, M., Yau‐Qiu, Z. X., Rodríguez, A. M., Palou, A., & Picó, C. (2021) · Nutrients · doi:10.3390/nu13093257 · Cited by 11

Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

Mohammed, I., Selvaraj, S., Ahmed, W. S., Al-Barazenji, T., Hammad, A. S., Dauleh, H., Saraiva, L. R., Al-Shafai, M. N., & Hussain, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216361 · Cited by 10

Melanocortin-4 receptor gene variants are not associated with binge-eating behavior in nonobese patients with eating disorders

Gamero‐Villarroel, C., Rodríguez‐López, R., Jimenez, M., Carrillo, J. A., García‐Herráiz, A., Albuquerque, D., Flores, I., & Gervasini, G. (2014) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000065 · Cited by 10

Metabolic and Hormonal Consequencies of the „Obesity Risk“ MC4R Variant (rs12970134) in Czech Women

Bradnová, O., Vejražková, D., Vaňková, M., Lukášová, P., Včelák, J., Stanická, S., DVOŘÁKOVÁ, K., & Bendlová, B. (2015) · Physiological Research · doi:10.33549/physiolres.933119 · Cited by 9

Aspects génétiques de l'obésité

Dubern, B., & Clément, K. (2007) · La Presse Médicale · doi:10.1016/j.lpm.2007.04.013 · Cited by 15

Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia

Knoll, S., Zimmer, S., Hinney, A., Scherag, A., Neubauer, A., & Hebebrand, J. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-85 · Cited by 10

Metformin inhibits the activation of melanocortin receptors 2 and 3 in vitro: A possible mechanism for its anti-androgenic and weight balancing effects in vivo?

Parween, S., Rihs, S., & Flück, C. E. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105684 · Cited by 10

Non-alcoholic Fatty Liver Disease

Smolle, E., Kessler, S. M., Golob, N., & Haybaeck, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-11251-0_36 · Cited by 10

Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions

Salazar-Valencia, I. G., Villamil‐Ramírez, H., Barajas-Olmos, F. M., Guevara‐Cruz, M., Kauffer, L. R. M., Garcia‐Ortíz, H., Hernández-Vergara, O., de Sandy-Galán, D. A. D., León‐Mimila, P., Centeno-Cruz, F., et al. (2022) · Genes · doi:10.3390/genes13122267 · Cited by 11

Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats

Spradley, F. T., Palei, A. C., & Granger, J. P. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001059 · Cited by 9

Translational science: Newly emerging science in biology and medicine — Lessons from translational research on the natriuretic peptide family and leptin —

Nakao, K. (2019) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.95.037 · Cited by 9

Predicting anthropometric and metabolic traits with a genetic risk score for obesity in a sample of Pakistanis

Rana, S., & Bhatti, A. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-87702-0 · Cited by 11

Role of the Melanocortin System in the Central Regulation of Cardiovascular Functions

Copperi, F., Kim, J. D., & Diano, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.725709 · Cited by 9

The Genetic Determinants of Common Obesity-Susceptibility

Loos, R. J. F. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_10 · Cited by 9

Neuroregulatory Peptides of Central Nervous System Origin: From Laboratory to Clinic

Geracioti, T. D., Strawn, J. R., Ekhator, N. N., Wortman, M. D., & Kasckow, J. W. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00082-6 · Cited by 11

Inactivating Melanocortin 4 Receptor Mutations and Human Obesity

Tao, Y. (2007) · Humana Press eBooks · doi:10.1007/978-1-60327-139-4_3 · Cited by 1

Deletion of Codons 88–92 of the Melanocortin-4 Receptor Gene: A Novel Deleterious Mutation in an Obese Female

Donohoue, P. A., Tao, Y., Collins, M. M., Yeo, G. S. H., O’Rahilly, S., & Segaloff, D. L. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030903 · Cited by 44

Genetic Screening for Melanocortin-4 Receptor Mutations in a Cohort of Italian Obese Patients: Description and Functional Characterization of a Novel Mutation

Santini, F., Maffei, M., Ceccarini, G., Pelosini, C., Scartabelli, G., Rosellini, V., Chiellini, C., Marsili, A., Lisi, S., Tonacchera, M., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031175 · Cited by 48

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

Farooqi, I. S., Yeo, G. S. H., Keogh, J. M., Aminian, S., Jebb, S. A., Butler, G. E., Cheetham, T. D., & O’Rahilly, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9397 · Cited by 801

Molecular Genetics of Human Obesity‐Associated MC4R Mutations

Lubrano-Berthelier, C., Cavazos, M. M., Dubern, B., Shapiro, A., Stunff, C. L., Zhang, S., Picart, F., Govaerts, C., Froguel, P., Bougneres, P. F., et al. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03161.x · Cited by 119