Cited by 275Platelet Disorders and TreatmentsCardiovascular, Neuropeptides, and Oxidative Stress ResearchBlood Coagulation and Thrombosis Mechanisms

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP

Open access

Kaufmann, Jocelyne E., Oksche, Alexander, Wollheim, Claes B., Günther, Gabriele, Rosenthal, Walter, Vischer, Ulrich M.·2000·Journal of Clinical Investigation

DOI 10.1172/jci9516PMC PMC314363

Open this paper in CoChat — free account Open PDF

Abstract

Vasopressin and its analogue 1-deamino-8-D-arginine vasopressin (DDAVP) are known to raise plasma von Willebrand factor (vWF) levels. DDAVP is used as a hemostatic agent for the treatment of von Willebrand's disease. However, its cellular mechanisms of action have not been elucidated. DDAVP, a specific agonist for the vasopressin V2 receptor (V2R), exerts its antidiuretic effect via a rise in cAMP in kidney collecting ducts. We tested the hypothesis that DDAVP induces vWF secretion by binding to V2R and activating cAMP-mediated signaling in endothelial cells. vWF secretion from human umbilical vein endothelial cells (HUVECs) can be mediated by cAMP, but DDAVP is ineffective, presumably due to the absence of V2R. We report that DDAVP stimulates vWF secretion in a cAMP-dependent manner in HUVECs after transfection of the V2R. In addition, vasopressin and DDAVP induce vWF secretion in human lung microvascular endothelial cells (HMVEC-L). These cells (but not HUVECs) express endogenous V2R, as shown by RT-PCR. Vasopressin-induced vWF secretion is mimicked by DDAVP and inhibited by the selective V2R antagonist SR121463B. It is mediated by cAMP, since it is inhibited by the protein kinase A inhibitor Rp-8CPT-cAMPS. These results indicate that vasopressin induces cAMP-mediated vWF secretion by a direct effect on endothelial cells. They also demonstrate functional expression of V2R in endothelial cells, and provide a cellular mechanism for the hemostatic effects of DDAVP.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci9516

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
BIOCHEMISTRY AND GENETICS OF VON WILLEBRAND FACTOR
Sadler, J. E. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.395 · Cited by 1,369
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969
Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells
Wagner, D. D. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.1.355 · Cited by 703
1-DEAMINO-8-D-ARGININE VASOPRESSIN: A NEW PHARMACOLOGICAL APPROACH TO THE MANAGEMENT OF HAEMOPHILIA AND VON WILLEBRAND'S DISEASE
Mannucci, P. M., Pareti, F. I., Ruggeri, Z. M., & Capitanio, A. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91197-7 · Cited by 604
Molecular cloning of the receptor for human antidiuretic hormone
Birnbaumer, M., Seibold, A. M., Gilbert, S., Ishido, M., Barberis, C., Antaramián, A., Brabet, P., & Rosenthal, W. (1992) · Nature · doi:10.1038/357333a0 · Cited by 539
Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus
Lolait, S. J., O'Carroll, A.-M., McBride, O. W., Konig, M., Morel, A., & Brownstein, M. J. (1992) · Nature · doi:10.1038/357336a0 · Cited by 524 · cited 1×
“This vasopressin receptor subtype is expressed in the principal cells of renal collecting ducts and mediates the antidiuretic effect of the hormone (7, 8).”
Background
Desmopressin (DDAVP) in the Treatment of Bleeding Disorders: The First 20 Years
Mannucci, P. M. (1997) · Blood · doi:10.1182/blood.v90.7.2515 · Cited by 436
Desmopressin (DDAVP) in the Treatment of Bleeding Disorders: The First 20 Years
Mannucci, P. M. (1997) · Blood · doi:10.1182/blood.v90.7.2515.2515_2515_2521 · Cited by 398
Mechanism of Plasminogen Activator and Factor VIII Increase after Vasoactive Drugs
Mannucci, P. M., Åberg, M., Nilsson, I. M., & Robertson, B. (1975) · British Journal of Haematology · doi:10.1111/j.1365-2141.1975.tb00521.x · Cited by 391

Flagged first, then by citations

Show all 47 references

Sorted by citations

von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA) 1
Nichols, W. L., Hultin, M., James, A., Manco‐Johnson, M. J., Montgomery, R. R., Ortel, T. L., Rick, M. E., Sadler, J. E., Weinstein, M., & Yawn, B. P. (2008) · Haemophilia · doi:10.1111/j.1365-2516.2007.01643.x · Cited by 967
Treatment of von Willebrand's Disease
Mannucci, P. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra040403 · Cited by 483
The vessel wall and its interactions
Wagner, D. D., & Frenette, P. S. (2008) · Blood · doi:10.1182/blood-2008-01-078204 · Cited by 357
Dynamics and Plasticity of Weibel-Palade Bodies in Endothelial Cells
Rondaij, M. G., Bierings, R., Kragt, A., van MOURIK, J. A., & Voorberg, J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000209501.56852.6c · Cited by 341
von Willebrand factor, endothelial dysfunction, and cardiovascular disease
Vischer, U. M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01949.x · Cited by 351
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development
Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337
Elevated Factor VIII Levels and the Risk of Thrombosis
Kamphuisen, P. W., Eikenboom, J. C. J., & Bertina, R. M. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.5.731 · Cited by 311
Functional architecture of Weibel-Palade bodies
Valentijn, K. M., Sadler, J. E., Valentijn, J. A., Voorberg, J., & Eikenboom, J. C. J. (2011) · Blood · doi:10.1182/blood-2010-09-267492 · Cited by 277
Cellular mechanisms of the hemostatic effects of desmopressin (DDAVP)
Kaufmann, J. E., & Vischer, U. M. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00190.x · Cited by 255
Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival
Haberichter, S. L., Balistreri, M., Christopherson, P. A., Morateck, P. A., Gavazova, S., Bellissimo, D. B., Manco‐Johnson, M. J., Gill, J. C., & Montgomery, R. R. (2006) · Blood · doi:10.1182/blood-2006-04-015065 · Cited by 218
Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD
Castaman, G., Lethagen, S., Federici, A. B., Tosetto, A., Goodeve, A. C., Budde, U., Batlle, J., Meyer, D., Mazurier, C., Fressinaud, É., et al. (2008) · Blood · doi:10.1182/blood-2007-08-109231 · Cited by 204
Desmopressin 30 Years in Clinical Use: A Safety Review
Walle, J. V., Stockner, M., Raes, A. M., & Nørgaard, J. P. (2007) · Current Drug Safety · doi:10.2174/157488607781668891 · Cited by 174
How I treat patients with von Willebrand disease
Mannucci, P. M. (2001) · Blood · doi:10.1182/blood.v97.7.1915 · Cited by 167
The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors
Juul, K. V., Bichet, D. G., Nielsen, S., & Nørgaard, J. P. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00604.2013 · Cited by 156
Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial
Laterre, P.-F., Berry, S. M., Blemings, A., Carlsen, J. E., François, B., Graves, T., Jacobsen, K., Lewis, R. J., Opal, S. M., Perner, A., et al. (2019) · JAMA · doi:10.1001/jama.2019.14607 · Cited by 147
Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo
Huber, D., Cramer, E. M., Kaufmann, J. E., Meda, P., Massé, J., Kruithof, E. K. O., & Vischer, U. M. (2002) · Blood · doi:10.1182/blood.v99.10.3637 · Cited by 131
Vasopressin-V2 Receptor Stimulation Reduces Sodium Excretion in Healthy Humans
Bankir, L., Fernandes, S., Bardoux, P., Bouby, N., & Bichet, D. G. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004121079 · Cited by 131
The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects
Colucci, G., Stutz, M., Rochat, S., Conte, T., Pavicic, M., Reusser, M., Giabbani, E., Huynh, A., Thürlemann, C., Keller, P., et al. (2014) · Blood · doi:10.1182/blood-2013-04-497123 · Cited by 117
FVIII production by human lung microvascular endothelial cells
Jacquemin, M. G., Neyrinck, A., Hermanns, M. I., Lavend’homme, R., Rega, F., Saint‐Remy, J., Peerlinck, K., Raemdonck, D. E. V., & Kirkpatrick, C. J. (2006) · Blood · doi:10.1182/blood-2005-11-4571 · Cited by 117
Neonatal DNA methylation patterns associate with gestational age
Schroeder, J. W., Conneely, K. N., Cubells, J. F., Kilaru, V., Newport, D. J., Knight, B. T., Stowe, Z. N., Brennan, P. A., Krushkal, J., Tylavsky, F. A., et al. (2011) · Epigenetics · doi:10.4161/epi.6.12.18296 · Cited by 114
Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall
Billaud, M., Lohman, A. W., Johnstone, S. R., Biwer, L. A., Mutchler, S. M., & Isakson, B. E. (2014) · Pharmacological Reviews · doi:10.1124/pr.112.007351 · Cited by 116
Exocytosis of Weibel–Palade bodies: how to unpack a vascular emergency kit
Schillemans, M., Karampini, E., Kat, M., & Bierings, R. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14322 · Cited by 109
A Review of the Nonpressor and Nonantidiuretic Actions of the Hormone Vasopressin
Mavani, G. P., DeVita, M. V., & Michelis, M. F. (2015) · Frontiers in Medicine · doi:10.3389/fmed.2015.00019 · Cited by 116
Evidence that vasopressin V1breceptors mediate the transition to excessive drinking in ethanol‐dependent rats
Edwards, S., Guerrero, M. A., Ghoneim, O. M., Roberts, E., & Koob, G. F. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00291.x · Cited by 104
The use of desmopressin in von Willebrand disease: the experience of the first 30 years (1977–2007)
Federici, A. B. (2007) · Haemophilia · doi:10.1111/j.1365-2516.2007.01610.x · Cited by 101
Molecular and Cellular Biology of von Willebrand Factor
Denis, C. V. (2002) · International Journal of Hematology · doi:10.1007/bf02981972 · Cited by 99
Copeptin is an independent predictor of diabetic heart disease and death
Enhörning, S., Hedblad, B., Nilsson, P. M., Engström, G., & Melander, O. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.11.020 · Cited by 99
Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system
Rotondo, F., Butz, H., Syro, L. V., Yousef, G. M., Di Ieva, A., Restrepo, L. M., Quintanar-Stephano, A., Berczi, I., & Kovacs, K. (2016) · Pituitary · doi:10.1007/s11102-015-0703-0 · Cited by 93
Perioperative management of von Willebrand disease: a review for the anesthesiologist
Mazzeffi, M. A., & Stone, M. E. (2011) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2011.02.003 · Cited by 92
Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease
Wang, J., Bouwens, E. A. M., Pintão, M. C., Voorberg, J., Safdar, H., Valentijn, K. M., de Boer, H. C., Mertens, K., Reitsma, P. H., & Eikenboom, J. C. J. (2013) · Blood · doi:10.1182/blood-2012-06-434373 · Cited by 91
Vasopressin V2 receptor antagonists
Wong, L.-J. C. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00315-7 · Cited by 89
Aquaporin 2 Mutations in Nephrogenic Diabetes Insipidus
Loonen, A. J. M., Knoers, N. V. A. M., van Os, C. H., & Deen, P. M. T. (2008) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2008.03.006 · Cited by 87
Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factor.
Meyer, S. D. D., Vanhoorelbeke, K., Chuah, M., Pareyn, I., Gillijns, V., Hebbel, R., Collen, D., Deckmyn, H., & VandenDriessche, T. (2006) · Blood · doi:10.1182/blood-2005-09-3605 · Cited by 91
Magnetic Resonance Imaging of the Hypothalamic‐Neurohypophyseal System
Fujisawa, I. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01183.x · Cited by 85
Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings
Turner, N. A., & Moake, J. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140740 · Cited by 84
Desmopressin in inherited disorders of platelet function
Coppola, A., & Minno, G. D. (2007) · Haemophilia · doi:10.1111/j.1365-2516.2007.01607.x · Cited by 80
Genetic regulation of plasma von Willebrand factor levels in health and disease
Swystun, L. L., & Lillicrap, D. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14304 · Cited by 79
Genetic Induction of a Releasable Pool of Factor VIII in Human Endothelial Cells
Rosenberg, J. B., Greengard, J. S., & Montgomery, R. R. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.12.2689 · Cited by 79
Shear Stress-Induced Activation of von Willebrand Factor and Cardiovascular Pathology
Денисович, О. С., Сергеевич, М. И., Avtaeva, Y., Kozlov, S. G., & Ахнафович, Г. З. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207804 · Cited by 76
Vascular endothelial growth factor regulation of Weibel-Palade–body exocytosis
Matsushita, K., Yamakuchi, M., Morrell, C. N., Ozaki, M., O'Rourke, B. P., Irani, K., & Lowenstein, C. J. (2004) · Blood · doi:10.1182/blood-2004-04-1519 · Cited by 76
Desmopressin (DDAVP) induces NO production in human endothelial cells via V2 receptor- and cAMP-mediated signaling
Kaufmann, J. E., Iezzi, M., & Vischer, U. M. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00197.x · Cited by 75
A Selective V1A Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock*
He, X., Su, F., Taccone, F. S., Laporte, R., Kjølbye, A. L., Zhang, J., Xie, K., Moussa, M. D., Reinheimer, T. M., & Vincent, J. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001380 · Cited by 75
Biosynthesis, processing and secretion of von Willebrand factor: biological implications
de Wit, T. R., & van MOURIK, J. A. (2001) · Best Practice & Research Clinical Haematology · doi:10.1053/beha.2001.0132 · Cited by 75
Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding
Svensson, P. J., Bergqvist, P. B. F., Juul, K. V., & Berntorp, E. E. (2014) · Blood Reviews · doi:10.1016/j.blre.2014.03.001 · Cited by 74
An Overview of SR121463, a Selective Non‐Peptide Vasopressin V2Receptor Antagonist
Gal, C. S. (2001) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2001.tb00065.x · Cited by 72
Influence of Platelet Count, Acetylsalicylic Acid, von Willebrand’s Disease, Coagulopathies, and Haematocrit on Results Obtained Using a Platelet Function Analyser in Dogs
Mischke, R. H., & Keidel, A. (2003) · The Veterinary Journal · doi:10.1016/s1090-0233(02)00169-7 · Cited by 71
Intersection of mechanisms of type 2A VWD through defects in VWF multimerization, secretion, ADAMTS-13 susceptibility, and regulated storage
Jacobi, P. M., Gill, J. C., Flood, V. H., Jakab, D., Friedman, K. D., & Haberichter, S. L. (2012) · Blood · doi:10.1182/blood-2011-06-360875 · Cited by 70
Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved?
Bankir, L., Ahloulay, M., Devreotes, P. N., & Parent, C. A. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00202.2001 · Cited by 69
Genetic Ablation of Adamts13 Gene Dramatically Accelerates the Formation of Early Atherosclerosis in a Murine Model
Jin, S., Tohyama, J., Bauer, R. C., Cao, N. N., Rader, D. J., & Zheng, X. L. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.247262 · Cited by 66
Characterization of a Novel Chemokine-Containing Storage Granule in Endothelial Cells: Evidence for Preferential Exocytosis Mediated by Protein Kinase A and Diacylglycerol
Øynebråten, I., Barois, N., Hagelsteen, K., Johansen, F., Bakke, O., & Haraldsen, G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5358 · Cited by 66
Vasopressin in vasodilatory and septic shock
Russell, J. A. (2007) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e328263885e · Cited by 65
Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage
Haberichter, S. L., Jacobi, P. M., & Montgomery, R. R. (2003) · Blood · doi:10.1182/blood-2002-07-2281 · Cited by 63
Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides
Glavaš, M., Gitlin‐Domagalska, A., Dębowski, D., Ptaszyńska, N., Łęgowska, A., & Rolka, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063068 · Cited by 63
Two Novel Aquaporin-2 Mutations Responsible for Congenital Nephrogenic Diabetes Insipidus in Chinese Families
Lin, S., Bichet, D. G., Sasaki, S., Kuwahara, M., Arthus, M., Lonergan, M., & Lin, Y. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.6.2694 · Cited by 61
cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2
Brandherm, I., Disse, J., Zeuschner, D., & Gerke, V. (2013) · Blood · doi:10.1182/blood-2012-12-475251 · Cited by 59
An open randomized controlled trial of desmopressin and pulse dexamethasone as adjunct therapy in patients with pulmonary involvement associated with severe leptospirosis
Niwattayakul, K., Kaewtasi, S., Chueasuwanchai, S., Hoontrakul, S., Chareonwat, S., Suttinont, C., Phimda, K., Chierakul, W., Silpasakorn, S., & Suputtamongkol, Y. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.03037.x · Cited by 58
STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a
van Breevoort, D., Snijders, A. P., Hellen, N., Weckhuysen, S., van Hooren, K. W. E. M., Eikenboom, J. C. J., Valentijn, K. M., Fernandez‐Borja, M., Ceulemans, B., Jonghe, P. D., et al. (2014) · Blood · doi:10.1182/blood-2013-10-535831 · Cited by 56
Expression and localisation of vascular ribonucleases in endothelial cells
Dadkhahi, S., Gansler, J., Saffarzadeh, M., Shibamiyama, A., Kral, N., Baal, N., Koyama, T., Deindl, E., Fischer, S., Nishio, M., et al. (2010) · Thrombosis and Haemostasis · doi:10.1160/th10-06-0345 · Cited by 55
Orthostatic Hypercoagulability
Masoud, M., Sarig, G., Brenner, B., & Jacob, G. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.112003 · Cited by 54
The Manifold Cellular Functions of von Willebrand Factor
Mojzisch, A., & Brehm, M. A. (2021) · Cells · doi:10.3390/cells10092351 · Cited by 59
Desmopressin Therapy for Massive Hemoptysis Associated with Severe Leptospirosis
Pea, L., Roda, L., Boussaud, V., & Lonjon, B. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200205-450cr · Cited by 54
Tuning the endothelial response: differential release of exocytic cargos from Weibel‐Palade bodies
Nightingale, T. D., McCormack, J. J., Grimes, W., Robinson, C., Lopes‐da‐Silva, M., White, I. J., Vaughan, A. N., Cramer, L. P., & Cutler, D. F. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14218 · Cited by 52
Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis
Ferguson, J., Therapondos, G., Newby, D. E., & Hayes, P. C. (2003) · Clinical Science · doi:10.1042/cs20030062 · Cited by 52
Von willebrand disease: An overview
Bharati, K., & Prashanth, U. (2011) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.89751 · Cited by 51
Small GTP-Binding Protein Ral Is Involved in cAMP-Mediated Release of von Willebrand Factor From Endothelial Cells
Rondaij, M. G., Sellink, E., Gijzen, K. A., ten Klooster, J. P., Hordijk, P. L., van MOURIK, J. A., & Voorberg, J. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000131267.13425.45 · Cited by 51
VON W ILLEBRAND F ACTOR AND VON W ILLEBRAND D ISEASE
Budde, U., & Schneppenheim, R. (2001) · Reviews in Clinical and Experimental Hematology · doi:10.1046/j.1468-0734.2001.00048.x · Cited by 51
Pathophysiology of copeptin in kidney disease and hypertension
Afşar, B. (2017) · Clinical Hypertension · doi:10.1186/s40885-017-0068-y · Cited by 51
How I treat low von Willebrand factor levels
Lavin, M., & O’Donnell, J. S. (2018) · Blood · doi:10.1182/blood-2018-10-844936 · Cited by 49
The role of V2 vasopressin antagonists in hyponatremia
Palm, C. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00288-7 · Cited by 49
How I treat bleeding disorder of unknown cause
Baker, R. I., & O’Donnell, J. S. (2021) · Blood · doi:10.1182/blood.2020010038 · Cited by 46
Vasopressin decreases sepsis-induced pulmonary inflammation through the V2R
Boyd, J. H., Holmes, C. L., Wang, Y., Roberts, H., & Walley, K. R. (2008) · Resuscitation · doi:10.1016/j.resuscitation.2008.07.006 · Cited by 46
Treatment of von Willebrand disease
Rodeghiero, F., & Castaman, G. (2005) · Seminars in Hematology · doi:10.1053/j.seminhematol.2004.10.001 · Cited by 45
The Von Willebrand Factor Propeptide (VWFpp) Traffics an Unrelated Protein to Storage
Haberichter, S. L., Jozwiak, M. A., Rosenberg, J. B., Christopherson, P. A., & Montgomery, R. R. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000017063.36768.87 · Cited by 45
Arginine Vasopressin-mediated Cardiac Differentiation
Gassanov, N., Jankowski, M., Danalache, B. A., Wang, D., Grygorczyk, R., Hoppe, U. C., & Gutkowska, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610769200 · Cited by 44
Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Gassanov, N., Semmo, N., Semmo, M., Nia, A. M., Fuhr, U., & Er, F. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1006-7 · Cited by 44
Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure
Rehsia, N. S., & Dhalla, N. S. (2009) · Heart Failure Reviews · doi:10.1007/s10741-009-9152-z · Cited by 43
Multi-omics delineation of cytokine-induced endothelial inflammatory states
Groten, S. A., Smit, E. R., Janssen, E. F. J., van den Eshof, B. L., van Alphen, F. P. J., van der Zwaan, C., Meijer, A. B., Hoogendijk, A. J., & van den Biggelaar, M. (2023) · Communications Biology · doi:10.1038/s42003-023-04897-w · Cited by 42
Dynein–Dynactin Complex Mediates Protein Kinase A–Dependent Clustering of Weibel-Palade Bodies in Endothelial Cells
Rondaij, M. G., Bierings, R., Kragt, A., Gijzen, K. A., Sellink, E., van MOURIK, J. A., Fernandez‐Borja, M., & Voorberg, J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000191639.08082.04 · Cited by 41
Reduction of tumor angiogenesis induced by desmopressin in a breast cancer model
Ripoll, G. V., Garona, J., Pífano, M., Fariña, H. G., Gomez, D. E., & Alonso, D. F. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2724-6 · Cited by 41
Pre‐treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex‐vivo model of swine‐to‐human pulmonary xenotransplantation
Kim, Y. T., Lee, H. J., Lee, S. W., Kim, J. Y., Wi, H. C., Park, S. J., Bae, S. J., & Kang, H. J. (2008) · Xenotransplantation · doi:10.1111/j.1399-3089.2008.00445.x · Cited by 40
Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP)
Olsen, E. H. N., McCain, A. S., Merricks, E. P., Fischer, T. H., Dillon, I. M., Raymer, R. A., Bellinger, D. A., Fahs, S. A., Montgomery, R. R., Keith, J. C., et al. (2003) · Blood · doi:10.1182/blood-2003-01-0290 · Cited by 40
The mutation N528S in the von Willebrand factor (VWF) propeptide causes defective multimerization and storage of VWF
Haberichter, S. L., Budde, U., Obser, T., Schneppenheim, S., Wermes, C., & Schneppenheim, R. (2010) · Blood · doi:10.1182/blood-2009-09-244327 · Cited by 39
Diabetes Insipidus: A Challenging Diagnosis with New Drug Therapies
Saifan, C., Nasr, R., Mehta, S. J., Acharya, P. S., Perrera, I., Faddoul, G., Nalluri, N., Kesavan, M., Azzi, Y. A., & El‐Sayegh, S. (2013) · ISRN Nephrology · doi:10.5402/2013/797620 · Cited by 39
Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity
Dyer, M., Plautz, W. E., Ragni, M. V., Alexander, W., Haldeman, S., Sperry, J. L., Guyette, F. X., Zuckerbraun, B. S., Rollins‐Raval, M. A., Raval, J. S., et al. (2020) · Transfusion · doi:10.1111/trf.15856 · Cited by 39
Shiga toxin enhances functional tissue factor on human glomerular endothelial cells: implications for the pathophysiology of hemolytic uremic syndrome
Nestoridi, E., Tsukurov, O. I., Kushak, R. I., Ingelfinger, J. R., & Grabowski, E. F. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01205.x · Cited by 39
The Epac-Rap1 Signaling Pathway Controls cAMP-mediated Exocytosis of Weibel-Palade Bodies in Endothelial Cells
van Hooren, K. W. E. M., van Agtmaal, E. L., Fernandez‐Borja, M., van MOURIK, J. A., Voorberg, J., & Bierings, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.321976 · Cited by 38
Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia
Mayer, B., Németh, K., Krepuska, M., Myneni, V. D., Maric, D., Tisdale, J. F., Hsieh, M. M., Uchida, N., Lee, H., Nemeth, M. J., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aao1632 · Cited by 40
Bleeding Risk and Management in Interventional Procedures in Chronic Liver Disease
DeAngelis, G. A., Khot, R., Haskal, Z. J., Maitland, H. S., Northup, P. G., Shah, N. L., & Caldwell, S. H. (2016) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2016.05.039 · Cited by 37
Myosin IIa is critical for cAMP-mediated endothelial secretion of von Willebrand factor
Li, P., Wei, G., Cao, Y., Deng, Q., Han, X., Huang, X., Huo, Y., He, Y., Chen, L., & Luo, J. (2017) · Blood · doi:10.1182/blood-2017-08-802140 · Cited by 37
Desmopressin in moderate hemophilia A patients: a treatment worth considering
Loomans, J. I., Kruip, M. J. H. A., Carcao, M. D., Jackson, S. C., van Velzen, A. S., Peters, M., Santagostino, E., Platokouki, H., Beckers, E. A. M., Voorberg, J., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.180059 · Cited by 37
Protein kinase C-δ mediates von Willebrand factor secretion from endothelial cells in response to vascular endothelial growth factor (VEGF) but not histamine
Lorenzi, O., Frieden, M., Villemin, P., FOURNIER, M., Foti, M., & Vischer, U. M. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03138.x · Cited by 37
Donor Desmopressin Is Associated With Superior Graft Survival After Kidney Transplantation
Benck, U., Göttmann, U., Hoeger, S., Lammert, A., Rose, D., Boesebeck, D., Lauchart, W., Birck, R., Weiß, C., Krämer, B. K., et al. (2011) · Transplantation · doi:10.1097/tp.0b013e318236cd4c · Cited by 37
The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models
Garona, J., Pífano, M., Orlando, U. D., Pastrián, M. B., Iannucci, N. B., Ortega, H. H., Podesta, E. J., Gomez, D. E., Ripoll, G. V., & Alonso, D. F. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2952 · Cited by 36
Use of Desmopressin for Unremitting Epistaxis following Septorhinoplasty and Turbinectomy
Faber, C., Larson, K. E., Amirlak, B., & Guyuron, B. (2011) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e318230bf39 · Cited by 35
A phase II prospective open‐label escalating dose trial of recombinant interleukin‐11 in mild von Willebrand disease
Ragni, M. V., Jankowitz, R. C., CHAPMAN, H. L., Merricks, E. P., Kloos, M. T., Dillow, A. M., & Nichols, T. C. (2008) · Haemophilia · doi:10.1111/j.1365-2516.2008.01827.x · Cited by 32
Dopamine modulates von Willebrand factor secretion in endothelial cells via D2–D4 receptors
Zarei, S. Z., Frieden, M., Rubı́, B., Villemin, P., Gauthier, B. R., Maechler, P., & Vischer, U. M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01998.x · Cited by 31
The pathophysiology of von Willebrand disease: therapeutic implications
Schneppenheim, R. (2011) · Thrombosis Research · doi:10.1016/s0049-3848(12)70002-6 · Cited by 31
Oxytocin receptor pattern of expression in primary lung cancer and in normal human lung
Péqueux, C., Breton, C., Hagelstein, M.-T., Geenen, V. G., & Legros, J. (2005) · Lung Cancer · doi:10.1016/j.lungcan.2005.05.027 · Cited by 30
The Crosstalk between Nephropathy and Coagulation Disorder: Pathogenesis, Treatment, and Dilemmas
Qiu, Z., Pang, X., Xiang, Q., & Cui, Y. (2023) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000199 · Cited by 31
Emerging mechanisms to modulate VWF release from endothelial cells
El-Mansi, S., & Nightingale, T. D. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105900 · Cited by 29

Authors: Kaufmann, J. E., Oksche, A., Wollheim, C. B., Günther, G., Rosenthal, W., & Vischer, U. M.
Affiliations: University of Geneva (CH)
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (DE)
Corresponding author: Kaufmann, Jocelyne E.
ORCID: Oksche, Alexander
Wollheim, Claes B.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2000-07-01
Volume: 106
Issue: 1
Pages: 107-116
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci9516
PMC: PMC314363
OpenAlex: W2052753575
Cited by: 275
References: 47
Citations by year: 2026: 5 · 2025: 9 · 2024: 6 · 2023: 14 · 2022: 11 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 15 · 2017: 7 · 2016: 13 · 2015: 12 · 2014: 13 · 2013: 15 · 2012: 8
FWCI: 4.71
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: Fonds National de la Recherche Luxembourg
Helmut Horten Stiftung
Topics: Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords: vasopressin, von Willebrand factor secretion, V2 receptor, cAMP signaling, protein kinase A, endothelial cells, desmopressin, von Willebrand disease, hemostasis, lung microvascular endothelial cells
MeSH terms: Cyclic AMP, Arginine Vasopressin, Cells, Cultured, Deamino Arginine Vasopressin, Endothelium, Vascular, Humans, Lung, RNA, Messenger, von Willebrand Factor, Receptors, Vasopressin, Reverse Transcriptase Polymerase Chain Reaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks