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Cited by 99Coffee research and impactsAttention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Acute effects of caffeine in normal prepubertal boys

R N Elkins, Judith L. Rapoport, Theodore P. Zahn, Monte S. Buchsbaum, Herbert Weingartner, Irwin J. Kopin, Dennis H. Langer, Christine Johnson·1981·American Journal of Psychiatry
DOI 10.1176/ajp.138.2.178
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Abstract

A recent study demonstrated that dextroamphetamine has an effect in normal prepubertal boys similar to that seen in hyperactive children. The purpose of the present study was to see whether the effects of caffeine are similar to those of amphetamine in normal children. The authors observed 19 prepubertal boys following administration of a single dose of placebo, 3 mg/kg of caffeine, and 10 mg/kg of caffeine in a double-blind, crossover design. Caffeine produced increased vigilance and decreased reaction time, as does amphetamine. Unlike amphetamine, however, the higher dose of caffeine did not have a motor calming effect but increased motor activity. Separate biological systems, therefore, may be differentially affected by the two substances.

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Crossref · 10.1176/ajp.138.2.178

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26 of 26 references verified0 citation errors · 0 not checkable

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  • No significant differences in self-rated anxiety or investigator-rated items of behaviour were found between placebo and caffeine at any dose.

    “No significant differences in self-rated anxiety or investigatorrated items of behaviour were found between placebo and caffeine at any dose.”

    From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Elkins et al., 1981

  • The Panel notes that the studies do not show an effect of single doses of caffeine ranging from 2.5 to 10 mg/kg body weight on most self-reported measures of anxiety in children.

    “The Panel notes that these studies (Elkins et al., 1981;Rapoport et al., 1981b;Bernstein et al., 1994) do not show an effect of single doses of caffeine ranging from 2.5 to 10 mg/kg bw on most selfreported measures of anxiety in children.”

    From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Elkins et al., 1981

  • Scores for feeling nervous or jittery were significantly higher for the 3 mg/kg body weight dose than for placebo, and for the 10 mg/kg body weight dose than for the 3 mg/kg body weight dose.

    “Scores for this side effect were significantly higher for the 3 mg/kg bw dose than for placebo, and for the 10 mg/kg bw dose than for the 3 mg/kg bw dose.”

    From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Elkins et al., 1981

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Authors
Elkins, R. N., Rapoport, J. L., Zahn, T. P., Buchsbaum, M. S., Weingartner, H., Kopin, I. J., Langer, D. H., & Johnson, C.
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1981-02-01
Volume
138
Issue
2
Pages
178-183
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.138.2.178
OpenAlex
W2466848435
Cited by
98
References
26
Citations by year
2024: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2012: 2
FWCI
5.49
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
caffeine, amphetamine, prepubertal boys, sustained attention, reaction time, motor activity, stimulant effects, hyperactivity, dose-response relationship
MeSH terms
Attention, Caffeine, Child, Child Behavior, Cognition, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Male, Motor Activity

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