The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
From metapsychology to molecular biology: explorations into the nature of anxiety
Abstract
Through the use of animal models, specific forms of mentation can now be explored on the cellular and molecular levels. Chronic anxiety and anticipatory anxiety in humans are closely paralleled by two forms of learned fear in the sea snail Aplysia: sensitization and aversive classical conditioning. In Aplysia's simple nervous system it is possible to delineate how the two forms are acquired and maintained. Both rely on the mechanisms of presynaptic facilitation. An augmented form of presynaptic facilitation accounts for the associative component of conditioning. These findings suggest that a surprisingly simple set of cellular and molecular mechanisms in various combinations may underlie a wide range of both adaptive and maladaptive behavioral modifications.
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Cites
Attachment and Loss. Vol. 1. Attachment
Rever, G. W. (1972) · Psychosomatic Medicine · doi:10.1097/00006842-197211000-00011 · Cited by 8,446
Skinner, B. F. (1957) · doi:10.1037/11256-000 · Cited by 5,759
Psychology as the behaviorist views it
Watson, J. B. (1913) · Psychological Review · doi:10.1037/h0074428 · Cited by 3,230
Gilbert, W. (1978) · Nature · doi:10.1038/271501a0 · Cited by 2,300
Conditioned emotional reactions.
Watson, J. B., & Rayner, R. (1920) · Journal of Experimental Psychology · doi:10.1037/h0069608 · Cited by 2,005
Probability of shock in the presence and absence of cs in fear conditioning.
Rescorla, R. A. (1968) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025984 · Cited by 1,067
How adaptive behavior is produced: a perceptual-motivational alternative to response reinforcements
Bindra, D. (1978) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00059380 · Cited by 732
A stimulus-response analysis of anxiety and its role as a reinforcing agent.
Mowrer, O. H. (1939) · Psychological Review · doi:10.1037/h0054288 · Cited by 728
Long-Term Sensitization of a Defensive Withdrawal Reflex in Aplysia
Pinsker, H. M., Hening, W. A., Carew, T. J., & Kandel, E. R. (1973) · Science · doi:10.1126/science.182.4116.1039 · Cited by 606
Self-citationMiller, N. E. (1948) · Journal of Experimental Psychology · doi:10.1037/h0058455 · Cited by 537
Cited by
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848
Autonomic balance revisited: Panic anxiety and heart rate variability
Friedman, B. H., & Thayer, J. F. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00202-x · Cited by 616
Startle reactivity and anxiety disorders: aversive conditioning, context, and neurobiology
Grillon, C. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01665-7 · Cited by 494
Stress-Response Syndromes: A Review of Posttraumatic and Adjustment Disorders
Horowitz, M. J. (1986) · Psychiatric Services · doi:10.1176/ps.37.3.241 · Cited by 481
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1983-10-01
- Volume
- 140
- Issue
- 10
- Pages
- 1277-1293
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W144537577
- Cited by
- 259
- References
- 11
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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