Differences in brain serotonergic metabolism between nonbulimic and bulimic patients with anorexia nervosa
Abstract
CSF concentrations of serotonin and dopamine metabolites in 16 patients with anorexia nervosa were measured before and after probenecid administration, and the patients were studied before and at intervals after weight recovery. After probenecid administration, the weight-recovered nonbulimic anorexic patients had a higher concentration of the serotonin metabolite, 5-hydroxyindoleacetic acid, than the weight-recovered bulimic patients but no significant differences in CSF homovanillic acid. This finding is consistent with evidence that suggests a role for brain serotonin metabolism in carbohydrate and mood regulation.
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The restricting anorexia nervosa subtype is clinically homogeneous.
“We focused on the RAN subtype because of its clinical homogeneity (Kaye et al. 1984; Herzog et al. 1996), which may represent a sample with greater genetic homogeneity.”
From Evidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1 (2002) · cites this paper as Kaye et al. 1984
Cites
Bulimia nervosa: an ominous variant of anorexia nervosa
RUSSELL, G. F. M. (1979) · Psychological Medicine · doi:10.1017/s0033291700031974 · Cited by 1,795 · see citing works
The Heterogeneity of Anorexia Nervosa
Garfinkel, P. E. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780220074008 · Cited by 568 · see citing works
‘Dieters’ and ‘vomiters and purgers’ in anorexia nervosa
Beumont, P. J. V., George, G. C. W., & Smart, D. E. (1977) · Psychological Medicine · doi:10.1017/s0033291700018250 · Cited by 276 · see citing works
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Toward a unified theory of serotonin dysregulation in eating and related disorders
Brewerton, T. D. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00001-5 · Cited by 245 · see citing works
Evidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1
Grice, D. E., Halmi, K. A., Fichter, M. M., Strober, M., Woodside, D. B., Treasure, J. T., Kaplan, A. S., Magistretti, P. J., Goldman, D., Bulik, C. M., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339250 · Cited by 222 · see citing works
Self-citationBailer, U. F., Frank, G. K., Henry, S. E., Price, J. C., Meltzer, C. C., Weissfeld, L., Mathis, C. A., Drevets, W. C., Wagner, A., Hoge, J., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.9.1032 · Cited by 182 · see citing works
Self-citationMDMA (“ecstasy”) abuse: Psychopathological features and craving for chocolate: A case series
Schifano, F., & Magni, G. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90088-4 · Cited by 58 · see citing works
Subtyping eating disorders: is it justified?
HERZOG, D. B., FIELD, A. E., KELLER, M. B., WEST, J. C., ROBBINS, W. M., STALEY, J., & COLDITZ, G. A. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199607000-00020 · Cited by 48 · see citing works
Paolacci, S., Kiani, A. K., Manara, E., Beccari, T., Ceccarini, M. R., Stuppia, L., Chiurazzi, P., Dalla Ragione, L., & Bertelli, M. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1244 · Cited by 47 · see citing works
- Authors
- Kaye, W. H., Ebert, M. H., Gwirtsman, H. E., & Weiss, S. R.
- Venue
- American Journal of Psychiatry
- Published
- 1984-12-01
- Volume
- 141
- Issue
- 12
- Pages
- 1598-1601
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2441005860
- Cited by
- 163
- References
- 3
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anorexia nervosa, bulimia nervosa, serotonin metabolism, brain serotonin, dopamine, cerebrospinal fluid, 5-hydroxyindoleacetic acid, homovanillic acid, probenecid, weight recovery, carbohydrate regulation, mood regulation
- MeSH terms
- Anorexia Nervosa, Appetite, Feeding and Eating Disorders, Body Weight, Brain, Brain Chemistry, Dopamine, Female, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Hyperphagia, Probenecid, Serotonin
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