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Reversible steroid dementia in patients without steroid psychosis
Abstract
Six patients developed dementia-like cognitive changes that appeared to result from administration of steroid medications. Four of the patients never showed symptoms of steroid psychosis; the remaining two continued to show steroid dementia well after their steroid psychoses had resolved. The dementia was characterized by deficits in memory retention, attention, concentration, mental speed and efficiency, and occupational performance. All six patients eventually recovered normal mental status following discontinuation or reduction of steroid medications. Larger prospective studies are needed to determine the prevalence and nature of the syndrome.
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From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [423]
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Metadata
- Authors
- Varney, N. R., Alexander, B., & MacIndoe, J. H.
- Venue
- American Journal of Psychiatry
- Published
- 1984-03-01
- Volume
- 141
- Issue
- 3
- Pages
- 369-372
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W109441170
- Cited by
- 194
- References
- 3
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 33 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 8 · 2014: 4 · 2013: 9 · 2012: 6
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- steroid psychosis, corticosteroid adverse effects, cognitive impairment, memory impairment, attention deficits, cognitive speed, occupational performance, recovery
- MeSH terms
- Adult, Aged, Alzheimer Disease, Attention, Cognition Disorders, Cortisone, Dementia, Diagnosis, Differential, Humans, Male, Memory Disorders, Middle Aged, Prednisone, Prospective Studies, Psychological Tests, Psychoses, Substance-Induced
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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