Cited by 21Stress Responses and CortisolTreatment of Major DepressionDementia and Cognitive Impairment Research

Depression-related cognitive impairment: possibilities for its pharmacological treatment

Mitchell, Alexander J., Dening, Thomas R.·1996·Journal of Affective Disorders

Abstract

Depression-related cognitive impairment (DRCI) is a condition which despite its initial treatment response, shows a progressive deterioration. No consistent therapeutic strategies have been proposed to combat this condition. This may be due to a reluctance to treat the cognitively impaired, a failure to recognise the deleterious prognosis or a poor understanding of the likely pathogenesis. Increasing evidence implicates the hypothalamo-pituitary-adrenal (HPA) axis as a key neurobiological determinant of the presentation and course of depression-induced cognitive decline. By utilising agents which control central glucocorticoid hyperactivity over a sustained period, whilst avoiding those agents which may compromise cognitive abilities, there exists a pharmacological strategy which may minimise the morbidity of cognitive impairment related to depressive illness.

Integrity signals

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Crossref · 10.1016/0165-0327(95)00070-4

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91 of 91 references verified0 citation errors · 0 not checkable

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  • Persisting depressive episodes are associated with hippocampal atrophy.

    “There is also evidence that persisting depressive episodes are associated with hippocampal atrophy (19), possibly as a result of impaired regulation of glucocorticoid secretion (20–21).”

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Authors
Mitchell, A. J., & Dening, T. R.
Affiliations
Fulbourn Hospital (GB)
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
1996-01
Volume
36
Issue
3-4
Pages
79-87
ISSN
0165-0327 (ISSN-L)
OpenAlex
W2160545001
Cited by
21
References
93
Citations by year
2024: 1 · 2021: 1 · 2020: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
0.15
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
hypothalamic-pituitary-adrenal axis, pharmacotherapy, antidepressants
MeSH terms
Aged, Animals, Antidepressive Agents, Cognition Disorders, Combined Modality Therapy, Dementia, Depressive Disorder, Electroconvulsive Therapy, Glucocorticoids, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System

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