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Sleep reduction as a final common pathway in the genesis of mania [published erratum appears in Am J Psychiatry 1987 Apr;144(4):542]
Abstract
Diverse psychological, interpersonal, environmental, and pharmacological factors that appear to trigger the onset of mania could act via their capacity to cause sleep deprivation, a mechanism that has been shown in experiments with bipolar patients to induce transient or sustained switches into mania. Since mania in turn causes insomnia, the development of mania is potentially self-reinforcing and could become autonomous after being initiated by precipitating factors. The sleep reduction model is based on experimental evidence and is a parsimonious explanation for the precipitation of manic episodes by a wide variety of factors. Furthermore, this model has clear implications for the prevention and treatment of mania and provides a conceptual focus and an experimental paradigm for psychological investigations of the causes of mania.
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“As reduced sleep is a common parameter in conditions causing mania in patients with bipolar disorder (75) and can also increase the chance of epileptic seizures (76, 77)”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [75]
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Self-citation
Metadata
- Authors
- Wehr, T. A., Sack, D. A., & Rosenthal, N. E.
- Venue
- American Journal of Psychiatry
- Published
- 1987-02-01
- Volume
- 144
- Issue
- 2
- Pages
- 201-204
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2338607498
- Cited by
- 346
- References
- 33
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 15 · 2013: 13 · 2012: 9
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- mania, sleep deprivation, bipolar disorder, insomnia, precipitating factors, mania treatment
- MeSH terms
- Adult, Bipolar Disorder, Female, Humans, Sleep Initiation and Maintenance Disorders, Life Change Events, Male, Middle Aged, Models, Psychological, Sleep Deprivation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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