Cited by 346Bipolar Disorder and TreatmentSleep and related disordersSleep and Wakefulness Research

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Sleep reduction as a final common pathway in the genesis of mania [published erratum appears in Am J Psychiatry 1987 Apr;144(4):542]

Thomas A. Wehr, David Allen Sack, N E Rosenthal·1987·American Journal of Psychiatry

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Abstract

Diverse psychological, interpersonal, environmental, and pharmacological factors that appear to trigger the onset of mania could act via their capacity to cause sleep deprivation, a mechanism that has been shown in experiments with bipolar patients to induce transient or sustained switches into mania. Since mania in turn causes insomnia, the development of mania is potentially self-reinforcing and could become autonomous after being initiated by precipitating factors. The sleep reduction model is based on experimental evidence and is a parsimonious explanation for the precipitation of manic episodes by a wide variety of factors. Furthermore, this model has clear implications for the prevention and treatment of mania and provides a conceptual focus and an experimental paradigm for psychological investigations of the causes of mania.

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Authors: Wehr, T. A., Sack, D. A., & Rosenthal, N. E.
ORCID: Thomas A. Wehr
David Allen Sack
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1987-02-01
Volume: 144
Issue: 2
Pages: 201-204
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.144.2.201
OpenAlex: W2338607498
Cited by: 346
References: 33
Citations by year: 2026: 4 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 15 · 2013: 13 · 2012: 9
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: mania, sleep deprivation, bipolar disorder, insomnia, precipitating factors, mania treatment
MeSH terms: Adult, Bipolar Disorder, Female, Humans, Sleep Initiation and Maintenance Disorders, Life Change Events, Male, Middle Aged, Models, Psychological, Sleep Deprivation

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Sleep reduction as a final common pathway in the genesis of mania [published erratum appears in Am J Psychiatry 1987 Apr;144(4):542]

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