The DOI matches its Crossref record.
CO2 challenge of patients with panic disorder
Abstract
In an open trial, five of eight panic disorder patients and none of five control subjects panicked after inhalation of two breaths of 35% CO2 and 65% O2; none panicked after placebo. Using 35% CO2 to induce panic is safe, simple, and well tolerated and may provide a valuable laboratory model of panic.
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“There is also a solid literature on panic induction by CO2 challenge tests (e.g., Fyer et al., 1987; Papp et al., 1993; Perna et al., 1994), which may be part of the reason the augmented respiratory relief intervention has received little further scrutiny.”
From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Fyer et al., 1987
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Sanderson, W. C. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810020059010 · Cited by 492
Carbon dioxide hypersensitivity, hyperventilation, and panic disorder
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.8.1149 · Cited by 272
Self-citationDiscomfort intolerance: Development of a construct and measure relevant to panic disorder
Schmidt, N. B., Richey, J. A., & Fitzpatrick, K. K. (2006) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2005.02.002 · Cited by 194
The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm
Ritz, T., Meuret, A. E., & Ayala, E. S. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.05.007 · Cited by 74
“There is also a solid literature on panic induction by CO2 challenge tests (e.g., Fyer et al., 1987; Papp et al., 1993; Perna et al., 1994), which may be part of the reason the augmented respiratory relief intervention has received little further scrutiny.”
BackgroundAntipanic Drug Modulation Of 35% CO2 Hyperreactivity and Short-Term Treatment Outcome
Perna, G., Bertani, A., Caldirola, D., Gabriele, A., Cocchi, S., & Bellodi, L. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200206000-00011 · Cited by 48
Metadata
- Authors
- Fyer, M. R., Uy, J., Martínez, J. A. B., Goetz, R. R., Klein, D. F., Fyer, A., Liebowitz, M. R., & Gorman, J.
- Venue
- American Journal of Psychiatry
- Published
- 1987-08-01
- Volume
- 144
- Issue
- 8
- Pages
- 1080-1082
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2413257731
- Cited by
- 116
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH30906, MH 00416, R01MH033422)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Keywords
- panic disorder, carbon dioxide inhalation, hypercapnia
- MeSH terms
- Administration, Inhalation, Adult, Anxiety Disorders, Carbon Dioxide, Fear, Humans, Oxygen, Panic, Pilot Projects
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