The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
High risk for attention deficit hyperactivity disorder among children of parents with childhood onset of the disorder: a pilot study
Abstract
OBJECTIVE: Although well-documented in clinical and epidemiological studies of attention deficit hyperactivity disorder (ADHD) in children, the familial nature of the adult syndrome has not been well investigated. One approach to evaluate the familial nature of adult ADHD is through a high-risk design aimed at estimating the risk for the disorder in children of parents with child-hood-onset ADHD. METHOD: Children at risk for ADHD were ascertained from the study group of 84 referred adults with clinical diagnoses of childhood onset of the disorder, confirmed by structured interviews. Diagnostic information on the disorder was derived from the ADHD module of the Schedule for Affective Disorders and Schizophrenia for School Age Children--Epidemiologic Version, supplemented with information regarding treatment for ADHD for the affected child and school history including repeated grades, placement in special classes, and tutoring. RESULTS: Of the 84 children at risk, 48 (57%) met criteria for ADHD. The rate of the disorder in children of adults with the disorder was significantly higher than the previously reported rate of ADHD among siblings of children with the disorder. Of the 48 ADHD children of parents with the disorder, 36 (75%) were treated for it. The rates of school failure were almost identical to those previously reported in a group of referred children and adolescents with ADHD. CONCLUSIONS: These results support the validity of the adult diagnosis of ADHD and suggest that the adult form of this disorder may have stronger familial etiological risk factors than its pediatric form. If these results are confirmed, families selected through adult probands with ADHD might be especially useful for testing genetic hypotheses about the disorder.
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“Finally, the high familial risk among first degree relatives, in the order of 20% or more [20,194], means that a strong predictor for the ADHD in adults is having a parent, sibling or child with ADHD.”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [194]
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Attention-Deficit/Hyperactivity Disorder: A Selective Overview
Biederman, J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.020 · Cited by 1,343
Self-citationJohnston, C., & Mash, E. J. (2001) · Clinical Child and Family Psychology Review · doi:10.1023/a:1017592030434 · Cited by 1,245
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“Finally, the high familial risk among first degree relatives, in the order of 20% or more [20,194], means that a strong predictor for the ADHD in adults is having a parent, sibling or child with ADHD.”
Structural Brain Imaging of Attention-Deficit/Hyperactivity Disorder
Seidman, L. J., Valera, E. M., & Makris, N. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.019 · Cited by 676
Kessler, R. C., Adler, L. A., Barkley, R., Biederman, J., Conners, C. K., Faraone, S. V., Greenhill, L. L., Jaeger, S., Secnik, K., Spencer, T., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.001 · Cited by 663
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Metadata
- Authors
- Biederman, J., Faraone, S. V., Mick, E. O., Spencer, T. J., Wilens, T., Kiely, K., Guite, J. W., Ablon, J. S., Reed, E. D., & Warburton, R.
- Affiliations
- Massachusetts General Hospital (US)
- Venue
- American Journal of Psychiatry
- Published
- 1995-03-01
- Volume
- 152
- Issue
- 3
- Pages
- 431-435
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2409126490
- Cited by
- 289
- References
- 36
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 4 · 2017: 10 · 2016: 9 · 2015: 9 · 2014: 10 · 2013: 17 · 2012: 18
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, adult ADHD, familial risk, school failure, ADHD treatment, referred children
- MeSH terms
- Achievement, Adolescent, Adult, Age Factors, Attention Deficit Disorder with Hyperactivity, Child, Data Collection, Education, Special, Family, Female, Humans, Male, Pilot Projects, Psychiatric Status Rating Scales, Risk Factors, Sensitivity and Specificity, Reproducibility of Results, Prevalence, Logistic Models, Age of Onset
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