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Cited by 289Attention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional DevelopmentAutism Spectrum Disorder Research

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

High risk for attention deficit hyperactivity disorder among children of parents with childhood onset of the disorder: a pilot study

Joseph Biederman, Stephen V. Faraone, Eric O. Mick, Thomas J. Spencer, Timothy Wilens, K Kiely, Jessica W. Guite, J. Stuart Ablon, Ellen D. Reed, R Warburton·1995·American Journal of Psychiatry
DOI 10.1176/ajp.152.3.431
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Abstract

OBJECTIVE: Although well-documented in clinical and epidemiological studies of attention deficit hyperactivity disorder (ADHD) in children, the familial nature of the adult syndrome has not been well investigated. One approach to evaluate the familial nature of adult ADHD is through a high-risk design aimed at estimating the risk for the disorder in children of parents with child-hood-onset ADHD. METHOD: Children at risk for ADHD were ascertained from the study group of 84 referred adults with clinical diagnoses of childhood onset of the disorder, confirmed by structured interviews. Diagnostic information on the disorder was derived from the ADHD module of the Schedule for Affective Disorders and Schizophrenia for School Age Children--Epidemiologic Version, supplemented with information regarding treatment for ADHD for the affected child and school history including repeated grades, placement in special classes, and tutoring. RESULTS: Of the 84 children at risk, 48 (57%) met criteria for ADHD. The rate of the disorder in children of adults with the disorder was significantly higher than the previously reported rate of ADHD among siblings of children with the disorder. Of the 48 ADHD children of parents with the disorder, 36 (75%) were treated for it. The rates of school failure were almost identical to those previously reported in a group of referred children and adolescents with ADHD. CONCLUSIONS: These results support the validity of the adult diagnosis of ADHD and suggest that the adult form of this disorder may have stronger familial etiological risk factors than its pediatric form. If these results are confirmed, families selected through adult probands with ADHD might be especially useful for testing genetic hypotheses about the disorder.

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Research works printed but not linked: 14

  1. Miller K, 1993, Jan 1 1
  2. Tsuang Ml, 1993, Famaone SV
  3. Famaone SV, 1992, Rosenbaum JF
  4. Famaone SV
  5. Famaone, Isuang M: Segregation analysis of attention deficit hyperactivity disorder: evidence for single gene transmission. Psychiatm Genetics I 992
  6. Famaone SV, 1993, Chen W
  7. Deutsch CK, Swanson JM
  8. Manshadi M, 1983, J Clin Psychiatry, 44, 379
  9. Spitzer RL, 1990, Gibbon M
  10. Orvaschel H, 1985, Psychopharmacol Bull, 21, 737
  11. Hubem PJ, Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability. I 967; 1:221-233
  12. Stata Corporation, 1992, Stata Reference Manual, release 3. 1
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  14. Spencer IJ, 1992, Scientific Proceedings ofthe Annual Meeting of the American Academy of Child and Adolescent Psychiatry

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Metadata

Authors
Biederman, J., Faraone, S. V., Mick, E. O., Spencer, T. J., Wilens, T., Kiely, K., Guite, J. W., Ablon, J. S., Reed, E. D., & Warburton, R.
Affiliations
Massachusetts General Hospital (US)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1995-03-01
Volume
152
Issue
3
Pages
431-435
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.152.3.431
OpenAlex
W2409126490
Cited by
289
References
36
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 4 · 2017: 10 · 2016: 9 · 2015: 9 · 2014: 10 · 2013: 17 · 2012: 18
FWCI
3.78
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
attention deficit hyperactivity disorder, adult ADHD, familial risk, school failure, ADHD treatment, referred children
MeSH terms
Achievement, Adolescent, Adult, Age Factors, Attention Deficit Disorder with Hyperactivity, Child, Data Collection, Education, Special, Family, Female, Humans, Male, Pilot Projects, Psychiatric Status Rating Scales, Risk Factors, Sensitivity and Specificity, Reproducibility of Results, Prevalence, Logistic Models, Age of Onset

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