Cited by 555Stress Responses and CortisolNeuropeptides and Animal PhysiologySuicide and Self-Harm Studies

Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims

Nemeroff, Charles B.·1988·Archives of General Psychiatry

Abstract

Previous studies have provided evidence that corticotropin releasing factor (CRF) is hypersecreted in patients with major depression. This CRF hypersecretion is believed to contribute at least in part to hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients. If CRF is chronically hypersecreted in depressed patients, then, due to down-regulation, a reduced number of CRF receptor binding sites should be present in patients with profound depressive disorder. To test this hypothesis, we measured the number and affinity of CRF binding sites in the frontal cortex of 26 suicide victims and 29 controls who died of a variety of causes. There was a marked (23%) reduction in the number of CRF binding sites in the frontal cortex of the suicide victims compared with the controls. These data are consistent with the hypothesis that CRF is hypersecreted in depression.

Integrity signals

Registry

Crossref · 10.1001/archpsyc.1988.01800300075009

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Nemeroff, C. B.
Affiliations
Duke Medical Center (US)
Corresponding author
Nemeroff, Charles B.
Venue
Archives of General Psychiatry
Published
1988-06-01
Volume
45
Issue
6
Pages
577
ISSN
0003-990X (ISSN-L)
OpenAlex
W2087334617
Cited by
555
References
1
Citations by year
2025: 2 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 12 · 2020: 7 · 2019: 14 · 2018: 5 · 2017: 8 · 2016: 13 · 2015: 10 · 2014: 20 · 2013: 16 · 2012: 17
FWCI
7.85
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Keywords
corticotropin-releasing factor, frontal cortex, suicide, major depressive disorder, hypothalamic-pituitary-adrenal axis, receptor down-regulation, postmortem brain
MeSH terms
Adult, Corticotropin-Releasing Hormone, Depressive Disorder, Female, Frontal Lobe, Humans, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Suicide, Receptors, Neurotransmitter, Receptors, Corticotropin-Releasing Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review