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Cited by 766

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

Gold, Philip W., Loriaux, D. Lynn, Roy, Alec, Kling, Mitchel A., Calabrese, Joseph R., Kellner, Charles H., Nieman, Lynnette K., Post, Robert M., Pickar, David, Gallucci, William, Avgerinos, Peter, Paul, Steven, Oldfield, Edward H., Cutler, Gordon B., Chrousos, George P.·1986·New England Journal of Medicine
DOI 10.1056/nejm198605223142101
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Abstract

Primary depression can be associated with substantial hypercortisolism, thus prompting some researchers to suggest that depression shares pathophysiologic features with Cushing's disease. Clinically, depression can be difficult or impossible to distinguish from mild or early Cushing's disease that is associated with depressive features. The purpose of this study was to evaluate whether the pituitary-adrenal responses to ovine corticotropin-releasing hormone could help to clarify the mechanism of hypercortisolism in depression and in Cushing's disease and to assist in the differential diagnosis of these disorders. As compared with controls (n = 34), depressed patients (n = 30) had basal hypercortisolism (P less than 0.001) that was associated with attenuated plasma ACTH responses to ovine corticotropin-releasing hormone (P less than 0.001). This indicates that in patients with depression, the corticotroph cell in the pituitary responds appropriately to the negative feedback of high cortisol levels. In contrast, patients with Cushing's disease (n = 29) had plasma ACTH hyperresponsiveness to ovine corticotropin-releasing hormone (P less than 0.001), despite basal hypercortisolism (P less than 0.001), which indicates a gross impairment of the mechanism by which cortisol exerts negative feedback on the pituitary. Less than 25 percent of the patients with depression or Cushing's disease had peak ACTH responses that overlapped. We conclude that the pathophysiologic features of hypercortisolism in depression and Cushing's disease are distinct in each of the disorders and that the ovine corticotropin-releasing hormone stimulation test can be helpful in their differential diagnosis.

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Citations

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Metadata

Authors
Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W., Avgerinos, P., Paul, S., Oldfield, E. H., Cutler, G. B., & Chrousos, G. P.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1986-05-22
Volume
314
Issue
21
Pages
1329-1335
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198605223142101
OpenAlex
W2323478895
Cited by
766
References
3
FWCI
24.52
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease. https://app.cochat.ai/papers/10.1056/nejm198605223142101
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Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W., Avgerinos, P., Paul, S., Oldfield, E. H., Cutler, G. B., & Chrousos, G. P. (1986). Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease. New England Journal of Medicine. https://doi.org/10.1056/nejm198605223142101

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.