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Cognitive behavior therapy for chronic fatigue syndrome: a randomized controlled trial.
Abstract
OBJECTIVE: Cognitive behavior therapy for chronic fatigue syndrome was compared with relaxation in a randomized controlled trial. METHODS: Sixty patients with chronic fatigue syndrome were randomly assigned to 13 sessions of either cognitive behavior therapy (graded activity and cognitive restructuring) or relaxation. Outcome was evaluated by using measures of functional impairment, fatigue, mood, and global improvement. RESULTS: Treatment was completed by 53 patients. Functional impairment and fatigue improved more in the group that received cognitive behavior therapy. At final follow-up, 70% of the completers in the cognitive behavior therapy group achieved good outcomes (substantial improvement in physical functioning) compared with 19% of those in the relaxation group who completed treatment. CONCLUSIONS: Cognitive behavior therapy was more effective than a relaxation control in the management of patients with chronic fatigue syndrome. Improvements were sustained over 6 months of follow-up.
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“CBT has been adapted and tested with CFS patients yielding superior results compared to standard medical treatment, relaxation, and adaptive pacing therapy (Sharpe et al., 1996; Deale et al., 1997; White et al., 2011), with moderate effect sizes (d = 0.48) (Malouff et al., 2008).”
From The relationship between improvement in insomnia severity and long-term outcomes in the treatment of chronic fatigue (2018) · cites this paper as Deale et al., 1997
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“The superiority of CBT compared to the control treatments became statistically significant, or increasingly apparent, several months after therapy had stopped.(55,56) Two RCTs of GET have been published.”
Background
Metadata
- Authors
- Deale, A. C., Chalder, T., Marks, I. M., & Wessely, S. C.
- Affiliations
- King's College London (GB)
- Venue
- American Journal of Psychiatry
- Published
- 1997-03-01
- Volume
- 154
- Issue
- 3
- Pages
- 408-414
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2122883493
- Cited by
- 491
- References
- 33
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 14 · 2012: 22
- FWCI
- 26.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- chronic fatigue syndrome, cognitive behavioral therapy, relaxation training, graded activity, cognitive restructuring, functional disability, fatigue, mood, treatment outcomes, follow-up
- MeSH terms
- Adult, Female, Follow-Up Studies, Health Status, Humans, Male, Patient Dropouts, Personality Inventory, Psychiatric Status Rating Scales, Relaxation Therapy, Fatigue Syndrome, Chronic, Cognitive Behavioral Therapy, Treatment Outcome
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