The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dopamine D4 Gene 7-Repeat Allele and Attention Deficit Hyperactivity Disorder
Open accessAbstract
OBJECTIVE: Family, twin, and adoption studies show attention deficit hyperactivity disorder (ADHD) to have a substantial genetic component, and some studies have reported an association between ADHD and the dopamine D4 (DRD4) gene. METHOD: The authors recruited 27 triads that comprised an ADHD adult, his or her spouse, and their ADHD child. These triads were assessed for ADHD, and their DNA was genotyped for DRD4 alleles. RESULTS: A multiallelic transmission disequilibrium test suggested an association between ADHD and the DRD4 7-repeat allele. Among family members, the number of 7-repeat alleles predicted the diagnosis of ADHD. CONCLUSIONS: Prior reports of an association between ADHD and DRD4 generalize to families recruited through clinically referred ADHD adults. However, because there are some conflicting studies, further work is needed to clarify the role of DRD4 in the etiology of the disorder.
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(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.431 · Cited by 289
Self-citation
Cited by
Johnston, C., & Mash, E. J. (2001) · Clinical Child and Family Psychology Review · doi:10.1023/a:1017592030434 · Cited by 1,161
Candidate gene studies of ADHD: a meta-analytic review
Gizer, I. R., Ficks, C., & Waldman, I. D. (2009) · Human Genetics · doi:10.1007/s00439-009-0694-x · Cited by 1,020
Insights into the neural basis of response inhibition from cognitive and clinical neuroscience
Chambers, C. D., Garavan, H., & Bellgrove, M. A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.016 · Cited by 938
Li, D., Sham, P. C., Owen, M. J., & He, L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl152 · Cited by 586
Swanson, J. M., Kinsbourne, M., Nigg, J., Lanphear, B., Stefanatos, G. A., Volkow, N., Taylor, E., Casey, B. J., Castellanos, F. X., & Wadhwa, P. D. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9019-9 · Cited by 580
Metadata
- Authors
- Faraone, S. V., Biederman, J., Weiffenbach, B., Keith, T., Chu, M. P., Weaver, A., Spencer, T. J., Wilens, T. E., Frazier, J., Cleves, M., & Sakai, J.
- Venue
- American Journal of Psychiatry
- Published
- 1999-05-01
- Volume
- 156
- Issue
- 5
- Pages
- 768-770
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2112151032
- Cited by
- 235
- References
- 1
- FWCI
- 19.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Faraone, S. V., Biederman, J., Weiffenbach, B., Keith, T., Chu, M. P., Weaver, A., Spencer, T. J., Wilens, T. E., Frazier, J., Cleves, M., & Sakai, J. (1999). Dopamine D4 Gene 7-Repeat Allele and Attention Deficit Hyperactivity Disorder. American Journal of Psychiatry. https://doi.org/10.1176/ajp.156.5.768
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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