The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Internalizing Behaviors in 4-Year-Old Children Exposed in Utero to Psychotropic Medications
Open accessAbstract
Objective: Internalizing behaviors in children between 4 and 5 years of age who had been prenatally exposed to psychotropic medications were investigated. The authors had previously reported the effects of prenatal medication exposure in this same cohort when they were newborns and infants at 3 and 8 months of age. Method: Parental/teacher reports and a clinical measure of mother and child interactions were used to assess levels of internalizing behaviors (e.g., depression, anxiety, withdrawal). Outcomes were compared between children with prenatal selective serotonin reuptake inhibitor (SSRI) exposure (N=22) and nonexposed children of healthy, nondepressed, nonmedicated mothers (N=14). Measures of maternal mood were obtained. Ordered logistic regressions, independent-sample t tests, and univariate ANOVAs were used to compare outcomes between groups. Pearson correlations were used to determine associations between maternal mood and child behaviors. Results: Levels of internalizing behaviors did not differ significantly between children with prenatal psychotropic medication exposure and those not exposed. However, as symptoms of maternal anxiety and depression increased, so did reported internalizing behaviors in their children. Conclusions: Prenatal exposure to psychotropic medications was not associated with increased reports of internalizing behaviors at 4 years of age, whereas impaired maternal mood did have an identified impact on child behavior. Further study of complex associations between maternal psychiatric disorders, prenatal SSRI exposure, and childhood internalizing behaviors is required to understand if the child outcome is affected by the illness, medications, or a combination of both.
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“Untreated PPD seems to have negative consequences for both infants and mothers.”
From Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes (2019) · cites this paper as [10]
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“Nonsystematic reviews have indicated that the risks to children of untreated depressed mothers (compared to mothers without PPD) include problems such as poor cognitive functioning, behavioral inhibition, emotional maladjustment, violent behavior, externalizing disorders, and psychiatric and medical disorders in adolescence.5,10–17”
From Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes (2019) · cites this paper as [10]
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Cites
Murray, L., Fiori-Cowley, A., Hooper, R., & Cooper, P. (1996) · Child Development · doi:10.2307/1131637 · Cited by 1,311
Murray, L., Fiori-Cowley, A., Hooper, R., & Cooper, P. (1996) · Child Development · doi:10.1111/j.1467-8624.1996.tb01871.x · Cited by 1,302
Cohort study of depressed mood during pregnancy and after childbirth
Evans, J., Heron, J., Francomb, H., Oke, S., & Golding, J. (2001) · BMJ · doi:10.1136/bmj.323.7307.257 · Cited by 1,273
Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years
O'Connor, T. G., Heron, J., Golding, J., Beveridge, M., & Glover, V. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.6.502 · Cited by 1,070
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817
den Bergh, B. R. H. V., & Marcoen, A. (2004) · Child Development · doi:10.1111/j.1467-8624.2004.00727.x · Cited by 627
Neurodevelopment of Children Exposed in Utero to Antidepressant Drugs
Nulman, I., ROVET, J. F., Stewart, D. E., Wolpin, J., Gardner, H. A., Theis, J. G. W., Kulin, N. A., & Koren, G. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701233360404 · Cited by 572
Three-Month-Old Infants' Reaction to Simulated Maternal Depression
Cohn, J. F., & Tronick, E. Z. (1983) · Child Development · doi:10.2307/1129876 · Cited by 535
Nulman, I., ROVET, J. F., Stewart, D. E., Wolpin, J., Pace‐Asciak, P., Shuhaiber, S., & Koren, G. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1889 · Cited by 440
Casper, R. C., Fleisher, B. E., Lee-Ancajas, J. C., Gilles, A. A., GAYLOR, E. E., DeBattista, A. M., & Hoyme, H. E. (2003) · The Journal of Pediatrics · doi:10.1067/mpd.2003.139 · Cited by 407
Children With Prepubertal-Onset Major Depressive Disorder and Anxiety Grown Up
Weissman, M. M., Wolk, S. I., WICKRAMARATNE, P. J., Goldstein, R. B., Adams, P., Greenwald, S., Ryan, N. D., Dahl, R. E., & Steinberg, D. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.9.794 · Cited by 391
The Cognitive Development of 5‐Year‐Old Children of Postnatally Depressed Mothers
Murray, L., Hipwell, A. E., Hooper, R., Stein, A. L., & Cooper, P. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01490.x · Cited by 305
Specificity of Infants' Response to Mothers' Affective Behavior
Cohn, J. F., & Tronick, E. Z. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198903000-00016 · Cited by 299
Infants of postpartum depressed mothers: Temperament and cognitive status.
Whiffen, V. E., & Gotlib, I. H. (1989) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.98.3.274 · Cited by 265
Oberlander, T. F., Misri, S. K., Fitzgerald, C., Kostaras, X., Rurak, D. W., & Riggs, W. K. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0214 · Cited by 244
Self-citationPathways to Violence in the Children of Mothers Who Were Depressed Postpartum.
Hay, D. F., Pawlby, S., Angold, A., Harold, G. T., & Sharp, D. (2003) · Developmental Psychology · doi:10.1037/0012-1649.39.6.1083 · Cited by 226
Infants of postpartum depressed mothers: Temperament and cognitive status.
Whiffen, V. E., & Gotlib, I. H. (1989) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.98.3.274 · Cited by 199
Relation between Prenatal Maternal Mood and Anxiety and Neonatal Health
Misri, S. K., Oberlander, T. F., Fairbrother, N., Carter, D., Ryan, D. M., Kuan, A. J., & Reebye, P. N. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404901006 · Cited by 68
Self-citationPreschool follow-up of infants of dysphoric mothers
Field, T. M., Lang, C., Martinez, A., Yando, R., Pickens, J., & Bendell, D. (1996) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp2503_3 · Cited by 36
Affect expression in prenatally psychotropic exposed and nonexposed mother–infant dyads
Reebye, P. N., Morison, S. J., Panikkar, H., Misri, S. K., & GRUNAU, R. E. (2002) · Infant Mental Health Journal · doi:10.1002/imhj.10025 · Cited by 28
Self-citation
Research works printed but not linked: 2
- Achenbach TM, 2001, Rescorla LA: Manual for the ASEBA Preschool Forms & Profiles. Burlington
- Mattson S, 1999, Teratology, 59, 376
Cited by
Sorted by citations
Consequences of maternal postpartum depression: A systematic review of maternal and infant outcomes
Slomian, J., Honvo, G., Emonts, P., Reginster, J.-Y., & Bruyère, O. (2019) · Women's Health · doi:10.1177/1745506519844044 · Cited by 1,496
Non-psychotic mental disorders in the perinatal period
Howard, L. M., Molyneaux, E., Dennis, C.-L., Rochat, T., Stein, A., & Milgrom, J. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61276-9 · Cited by 1,328
Pearlstein, T., Howard, M., Salisbury, A., & Zlotnick, C. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.11.033 · Cited by 462
Major Depression and Antidepressant Treatment: Impact on Pregnancy and Neonatal Outcomes
Wisner, K. L., Sit, D. K. Y., Hanusa, B. H., Moses‐Kolko, E. L., Bogen, D. L., Hunker, D. F., Perel, J. M., Jones-Ivy, S., Bodnar, L. M., & Singer, L. T. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081170 · Cited by 400
Psychopharmacological Treatment for Very Young Children: Contexts and Guidelines
Gleason, M. M., EGGER, H. L., Emslie, G. J., Greenhill, L. L., Kowatch, R. A., Lieberman, A. F., Luby, J. L., Owens, J. A., Scahill, L. D., Scheeringa, M. S., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181570d9e · Cited by 247
Metadata
- Authors
- Misri, S., Reebye, P., Kendrick, K., Carter, D., Ryan, D., Grunau, R. E., & Oberlander, T. F.
- Affiliations
- St. Paul's Hospital (CA)
- Corresponding author
- Misri, Shaila
- Venue
- American Journal of Psychiatry
- Published
- 2006-06
- Volume
- 163
- Issue
- 6
- Pages
- 1026-1032
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1989830600
- Cited by
- 207
- References
- 18
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 10 · 2022: 12 · 2021: 5 · 2020: 8 · 2019: 12 · 2018: 6 · 2017: 12 · 2016: 13 · 2015: 8 · 2014: 19 · 2013: 12 · 2012: 11
- FWCI
- 11.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- internalizing problems, selective serotonin reuptake inhibitors, maternal depression, maternal anxiety, maternal mood, child behavior, preschool children, mother-child interaction, maternal mental illness
- MeSH terms
- Adult, Affect, Age Factors, Anxiety Disorders, Child Behavior Disorders, Child, Preschool, Depressive Disorder, Female, Humans, Maternal-Fetal Exchange, Mother-Child Relations, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Psychotropic Drugs, Reproducibility of Results, Cohort Studies, Logistic Models, Child of Impaired Parents, Maternal Exposure
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