Cited by 151HIV, Drug Use, Sexual RiskNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Stimulant-induced enhanced sexual desire as a potential contributing factor in HIV transmission

Volkow, Nora D., Wang, Gene-Jack, Fowler, Joanna S., Telang, Frank, Jayne, Millard, Wong, Christopher·2007·American Journal of Psychiatry

Abstract

OBJECTIVE: Stimulant abuse is associated with an increased risk of contracting human immunodeficiency virus (HIV). Although sharing of contaminated needles is one of the routes by which HIV is spread, noninjection abusers are also at high risk. The authors investigated the effect of the stimulant drug methylphenidate (given intravenously) on sexual desire as a possible contributing factor to risky sexual behavior associated with the contraction of HIV. METHOD: The effects of intravenous methylphenidate (0.5 mg/kg) on self-reports of sexual desire (rated from 0-10) were evaluated in 39 comparison subjects and 39 cocaine abusers. RESULTS: Intravenous methylphenidate significantly increased self-reports of sexual desire in comparison subjects (1.4 versus 3.7) and cocaine abusers (2.8 versus 4.8). CONCLUSIONS: Stimulant-induced enhancement of sexual desire could be one mechanism by which stimulant drugs such as cocaine and methamphetamine increase the risk for HIV transmission even when they are not injected.

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Crossref · 10.1176/ajp.2007.164.1.157

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Authors
Volkow, N. D., Wang, G.-J., Fowler, J. S., Telang, F., Jayne, M., & Wong, C.
Affiliations
National Institute on Drug Abuse (US)
Venue
American Journal of Psychiatry
Published
2007-01
Volume
164
Issue
1
Pages
157-160
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2158876851
Cited by
151
References
16
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 12 · 2017: 7 · 2016: 13 · 2015: 5 · 2014: 9 · 2013: 8 · 2012: 6
FWCI
9.39
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
HIV transmission, sexual desire, stimulant abuse, cocaine, methylphenidate, methamphetamine, sexual risk behavior, HIV risk factors
MeSH terms
Administration, Oral, Adult, Central Nervous System Stimulants, Dose-Response Relationship, Drug, Female, Humans, Injections, Intravenous, Libido, Male, Methamphetamine, Methylphenidate, Placebos, Risk-Taking, Sexual Behavior, HIV Infections, Comorbidity, Cocaine-Related Disorders

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