Methamphetamine administration dose effects on sexual desire, sexual decision making, and delay discounting
Open accessAbstract
= 19) participated in this within-subject, placebo-controlled study comparing the effects of 0 mg, 20 mg, and 40 mg of oral methamphetamine. Compared to placebo, methamphetamine caused dose-related and time-related increases in a single-item sexual desire rating and some standard stimulant abuse liability ratings, as well as dose-related increases in the Sexual Arousal and Desire Inventory (SADI; a multidimensional scale capturing positive and negative aspects of desire/arousal). However, methamphetamine caused no significant mean differences in likelihood of condom use within the Sexual Delay Discounting Task or the Monetary Discounting Task. SADI scores were negatively correlated with change from placebo in condom use likelihood in the Sexual Delay Discounting Task for some partner conditions (i.e., decreased reported likelihood of condom use in participants who experienced increased desire/arousal and vice versa). These mixed results may be consistent with methamphetamine's role as both a treatment for attention-deficit/hyperactivity disorder and as a drug of abuse associated with increased delay discounting, and they suggest that methamphetamine's effects on discounting may be modulated by the reinforcing properties of what is being discounted. Delay discounting may be an understudied element of risky sexual decision making, particularly among individuals who use methamphetamine. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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Stimulants are associated with increased risk-taking and delay discounting.
“They are associated with increased risk-taking and delay discounting (Berry et al., 2022;Skryabin et al., 2020;Volkow et al., 2007).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Berry et al., 2022
The Introduction (page unavailable) associates dopaminergic stimulants with increased sexual risk and reports greater delay discounting among people who misuse methamphetamine. The claim broadens sexual risk to risk-taking generally and leaves out the paper’s qualification that acute stimulant effects on delay discounting are mixed; the Discussion also reports varied responses to methamphetamine. (LLM, conf=0.83)
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- Authors
- Berry, M. S., Bruner, N. R., Herrmann, E. S., Johnson, P. S., & Johnson, M. W.
- Corresponding author
- Berry, Meredith S.
- Johnson, Matthew W.
- Venue
- Experimental and Clinical Psychopharmacology
- Published
- 2022-04
- Volume
- 30
- Issue
- 2
- Pages
- 180-193
- ISSN
- 1064-1297 (ISSN-L)
- 1936-2293
- PMC
- PMC8862632
- OpenAlex
- W3091468177
- Cited by
- 26
- References
- 66
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 2 · 2023: 6 · 2022: 3 · 2020: 1
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Experimental and Clinical Psychopharmacology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R21DA032717; R01DA032363, T32DA07209)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- methamphetamine, sexual desire, sexual decision-making, delay discounting, condom use, sexual arousal, sexual risk behavior, ADHD treatment, dosage effect
- MeSH terms
- Decision Making, Humans, Methamphetamine, Sexual Behavior, Condoms, Safe Sex, Delay Discounting
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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