Cited by 151HIV, Drug Use, Sexual RiskNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

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Stimulant-Induced Enhanced Sexual Desire as a Potential Contributing Factor in HIV Transmission

Volkow, Nora D., Wang, Gene-Jack, Fowler, Joanna S., Telang, Frank, Jayne, Millard, Wong, Christopher·2007·American Journal of Psychiatry

DOI 10.1176/ajp.2007.164.1.157

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Abstract

OBJECTIVE: Stimulant abuse is associated with an increased risk of contracting human immunodeficiency virus (HIV). Although sharing of contaminated needles is one of the routes by which HIV is spread, noninjection abusers are also at high risk. The authors investigated the effect of the stimulant drug methylphenidate (given intravenously) on sexual desire as a possible contributing factor to risky sexual behavior associated with the contraction of HIV. METHOD: The effects of intravenous methylphenidate (0.5 mg/kg) on self-reports of sexual desire (rated from 0-10) were evaluated in 39 comparison subjects and 39 cocaine abusers. RESULTS: Intravenous methylphenidate significantly increased self-reports of sexual desire in comparison subjects (1.4 versus 3.7) and cocaine abusers (2.8 versus 4.8). CONCLUSIONS: Stimulant-induced enhancement of sexual desire could be one mechanism by which stimulant drugs such as cocaine and methamphetamine increase the risk for HIV transmission even when they are not injected.

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Authors: Volkow, N. D., Wang, G.-J., Fowler, J. S., Telang, F., Jayne, M., & Wong, C.
Affiliations: National Institute on Drug Abuse (US)
ORCID: Volkow, Nora D.
Wang, Gene-Jack
Wong, Christopher
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2007-01
Volume: 164
Issue: 1
Pages: 157-160
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.2007.164.1.157
OpenAlex: W2158876851
Cited by: 151
References: 16
Citations by year: 2026: 4 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 12 · 2017: 7 · 2016: 13 · 2015: 5 · 2014: 9 · 2013: 8 · 2012: 6
FWCI: 9.39
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: HIV transmission, sexual desire, stimulant abuse, cocaine, methylphenidate, methamphetamine, sexual risk behavior, HIV risk factors
MeSH terms: Administration, Oral, Adult, Central Nervous System Stimulants, Dose-Response Relationship, Drug, Female, Humans, Injections, Intravenous, Libido, Male, Methamphetamine, Methylphenidate, Placebos, Risk-Taking, Sexual Behavior, HIV Infections, Comorbidity, Cocaine-Related Disorders

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Stimulant-Induced Enhanced Sexual Desire as a Potential Contributing Factor in HIV Transmission

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