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Impaired Cognitive Flexibility and Motor Inhibition in Unaffected First-Degree Relatives of Patients With Obsessive-Compulsive Disorder
Open accessAbstract
OBJECTIVE: Obsessive-compulsive disorder (OCD) is highly heritable. Attempts to delineate precise genetic contributions have met with limited success. There is an ongoing search for intermediate cognitive brain markers (endophenotypes) that may help clarify genetic contributions. The aim was to assess inhibitory control processes in unaffected first-degree relatives of OCD patients for the first time with objective tests. METHOD: The Intradimensional/Extradimensional Shift, Stop-Signal, and Cambridge Gamble tasks were administered to 20 unaffected first-degree relatives, 20 OCD patient probands with washing/checking symptoms, and 20 healthy matched comparison subjects without a family history of OCD. RESULTS: Unaffected first-degree relatives and OCD patient probands showed cognitive inflexibility (extradimensional set shifting) and motor impulsivity (stop-signal reaction times). Decision making (Cambridge Gamble task) was intact. CONCLUSIONS: Deficits in cognitive flexibility and motor inhibition may represent cognitive endophenotypes for OCD. Such measures will play a key role in understanding genotype/phenotype associations for OCD and related spectrum conditions.
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“Importantly, these deficits persist in remitted patients and are also observed in unaffected first-degree relatives (10, 11, 19), supporting the view that cognitive inflexibility represents a candidate endophenotype (or trait-like marker) of OCD.”
From Neural mechanisms underlying cognitive inflexibility in obsessive-compulsive disorder: a review (2026) · cites this paper as [19]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Impaired action cancelation and action restraint has been described for OCD (Chamberlain et al., 2007b; Penades et al., 2007); patients showed increased SSRT (i.e., slower inhibition) in the Stop-signal task and higher error rates on the Go/No Go task compared with healthy control subjects.”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Chamberlain et al., 2007b
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Experimental studies using tasks such as the stop-signal task, intradimensional/extradimensional (ID/ED) set-shifting task, reversal-learning paradigms, and Tower of London planning tasks have further shown that patients with OCD often require greater cognitive effort to inhibit prepotent responses, adapt to changing contingencies, or organise goal-directed behaviour [5,6,7,8].”
From Electrophysiological Correlates of Cognitive Dysfunction in Obsessive-Compulsive Disorder (OCD): A Systematic and Mechanistic Review of EEG, ERP, and QEEG Evidence (2026) · cites this paper as [8]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Deficits in motor response inhibition were also observed in unaffected first-degree relatives of OCD patients (Chamberlain et al., 2007b; Menzies et al., 2007), suggesting that motor response inhibition may be considered an endophenotype”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Chamberlain et al., 2007b
In the citing paper
“evidence from recent human studies suggests that OCD patients have dysfunction in core neural processes mapped onto CSTC circuits, such as response inhibition 70,71,72 and sensorimotor gating 73.”
From DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS: Review: Dissecting OCD Circuits: Animals to Treatments (2015) · cites this paper as [72]
In the citing paper
“and switching between rules (extradimensional set-shifting) (22)”
From Enhanced avoidance habits in obsessive-compulsive disorder (2014) · cites this paper as [22]
In the citing paper
“Behaviorally, OCD patient probands and their unaffected first-degree relatives (UFDR) showed cognitive inflexibility (Chamberlain et al., 2007).”
From Imbalance between the caudate and putamen connectivity in obsessive–compulsive disorder (2022) · cites this paper as Chamberlain et al., 2007
In the citing paper
“These deficits represent trait rather than state impairments, that can exist in the absence of medication confounds and clinical phenotype (Chamberlain et al., 2007).”
From Imbalance between the caudate and putamen connectivity in obsessive–compulsive disorder (2022) · cites this paper as Chamberlain et al., 2007
In the citing paper
“Impaired motor response inhibition is also observed in unaffected first-degree relatives of OCD patients (Chamberlain et al., 2007) suggesting that motor response inhibition may be considered an endophenotype for OCD.”
From The role of habit in compulsivity (2016) · cites this paper as Chamberlain et al., 2007
In the citing paper
“In contrast, differences in SSRT have been found for adolescents and adults with OCD (Chamberlain et al., 2007; Kang et al., 2013; Penadés et al., 2007; de Wit et al., 2012), suggesting that for individuals with OCD, problems with cognitive control may emerge later in development.”
From No evidence of differences in cognitive control in children with autism spectrum disorder or obsessive-compulsive disorder: An fMRI study (2019) · cites this paper as Chamberlain et al., 2007
In the citing paper
“Findings in OCD and ASD using this task have been mixed: increased SSRTs have been reported for individuals with OCD (Chamberlain et al., 2007; Kang et al., 2013; Mancini et al., 2018; Penadés et al., 2007; de Wit et al., 2012) and children with ASD (Geurts et al., 2004; Lemon et al., 2011), while other studies have found no differences (Adams and Jarrold, 2012; Chantiluke et al., 2015; Fan et al.”
From No evidence of differences in cognitive control in children with autism spectrum disorder or obsessive-compulsive disorder: An fMRI study (2019) · cites this paper as Chamberlain et al., 2007
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Citations
Cites
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962
(1998) · PubMed · Cited by 10,216
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197
Self-citationRogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101
Toward a neurobiology of obsessive-compulsive disorder
Graybiel, A. M., & Rauch, S. L. (2000) · Neuron · doi:10.1016/s0896-6273(00)00113-6 · Cited by 864
Chamberlain, S. R., Blackwell, A. D., Fineberg, N. A., Robbins, T. W., & Sahakian, B. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.11.006 · Cited by 830
Self-citationDecision-making processes following damage to the prefrontal cortex
Manes, F., Sahakian, B., Clark, L., Rogers, R., Antoun, N., Aitken, M., & Robbins, T. (2002) · Brain · doi:10.1093/brain/awf049 · Cited by 799
Self-citationA Family Study of Obsessive-compulsive Disorder
Nestadt, G., Samuels, J., Riddle, M., Bienvenu, O. J., Liang, K.-Y., LaBuda, M., Walkup, J., Grados, M., & Hoehn-Saric, R. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.358 · Cited by 657
Flagged first, then by citations
Research works printed but not linked: 3
- Sheehan DV, 1998, J Clin Psychiatry, 59, 22
- Nelson HE, 1982, National Adult Reading Test (NART): Test Manual
- 10.1176/appi.neuropsych.17.2.208 · DOI
Cited by
Sorted by citations
Items 201–300 of 441
Hollestein, V., Buitelaar, J. K., Brandeis, D., Banaschewski, T., Kaiser, A., Hohmann, S., Oranje, B., Gooskens, B., Durston, S., Williams, S., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102622 · Cited by 29
Neuronal population dynamics during motor plan cancellation in nonhuman primates
Pani, P., Giamundo, M., Giarrocco, F., Mione, V., Fontana, R., Brunamonti, E., Mattia, M., & Ferraina, S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2122395119 · Cited by 27
Memory and strategic processing in first-degree relatives of obsessive compulsive patients
Segalàs, C., Alonso, P., Real, E., Verdejo‐García, A., Miñambres, A., Labad, J., Pertusa, A., Bueno, B., Jiménez‐Múrcia, S., & Menchón, J. M. (2010) · Psychological Medicine · doi:10.1017/s0033291710000310 · Cited by 26
Problematic internet use in gamblers: impact on clinical and cognitive measures
Chamberlain, S. R., Redden, S. A., Leppink, E. W., & Grant, J. E. (2017) · CNS Spectrums · doi:10.1017/s1092852917000037 · Cited by 26
Self-citationZartaloudi, E., Laws, K. R., & Bramon, E. (2019) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000241 · Cited by 25
Impaired executive functions in paediatric obsessive-compulsive disorder patients
Taner, Y. I., Bakar, E. E., & Öner, Ö. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00562.x · Cited by 25
Refractory OCD Due to Thalamic Infarct With Response to Dronabinol
Cooper, J. J., & Grant, J. E. (2016) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.16030053 · Cited by 25
Sanches, M., Scott-Gurnell, K., Patel, A. K., Caetano, S. C., Zunta‐Soares, G. B., Hatch, J. P., Olvera, R. L., Swann, A. C., & Soares, J. C. (2014) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2014.04.018 · Cited by 25
Gooskens, B., Bos, D. J., Mensen, V. T., Shook, D. A., Bruchhage, M. M. K., Naaijen, J., Wolf, I., Brandeis, D., Williams, S. C. R., Buitelaar, J. K., et al. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.11.004 · Cited by 24
Zhukovsky, P., Alsiö, J., Jupp, B., Xia, J., Guiliano, C., Jenner, L., Griffiths, J., Riley, E., Ali, S., Roberts, A., et al. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4569-x · Cited by 25
Self-citationPark, J., Kim, T., Kim, M., Lee, T. Y., & Kwon, J. S. (2020) · Psychiatry Investigation · doi:10.30773/pi.2019.0206 · Cited by 25
Disrupted cortical network as a vulnerability marker for obsessive–compulsive disorder
Peng, Z., Shi, F., Shi, C., Yang, Q., Chan, R. C. K., & Shen, D. G. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0602-y · Cited by 25
Did i do that? Cognitive flexibility and self-agency in patients with obsessivecompulsive disorder
Giuliani, M., Martoni, R. M., Crespi, S. A., O’Neill, J., Erzegovesi, S., de’Sperati, C., & Grgič, R. G. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114170 · Cited by 25
Fan, J., Zhong, M., Zhu, X., Lei, H., Dong, J., Zhou, C., & Liu, W. (2014) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.11.002 · Cited by 23
Francazio, S. K., & Flessner, C. A. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.04.038 · Cited by 26
Saremi, A. A., Department of Cognitive Neuroscience, I. F. C. S. S. (., Shariat, S. V., Mental Health Research Center, T. I. O. P., Nazari, M. A., Department of Psychology, F. O. E. &. P., Dolatshahi, B., & Department of Psychology, U. O. S. W. A. R. S. (2017) · Basic and Clinical Neuroscience Journal · doi:10.18869/nirp.bcn.8.3.233 · Cited by 22
New treatment models for compulsive disorders
Grant, J. E., Fineberg, N. A., Ameringen, M. V., Cath, D. C., Visser, H. A. D., Carmi, L., Pallanti, S., Hollander, E., & van Balkom, A. J. L. M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.008 · Cited by 24
Self-citationBey, K., Kaufmann, C., Lennertz, L., Riesel, A., Klawohn, J., Heinzel, S., Grützmann, R., Kathmann, N., & Wagner, M. (2018) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2018.05.009 · Cited by 22
Bey, K., Lennertz, L., Grützmann, R., Heinzel, S., Kaufmann, C., Klawohn, J., Riesel, A., Meyhöfer, I., Ettinger, U., Kathmann, N., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00284 · Cited by 22
Cognitive Flexibility and Social Responsiveness in Children and Adolescents with Tourette Syndrome
Güler, A. S., Berkem, M., Yazgan, Y., & Kalaça, S. (2015) · Child Psychiatry & Human Development · doi:10.1007/s10578-015-0533-3 · Cited by 27
Cognitive Performance in a Subclinical Obsessive-Compulsive Sample 1: Cognitive Functions
Johansen, T., & Dittrich, W. H. (2013) · Psychiatry Journal · doi:10.1155/2013/565191 · Cited by 21
“Following this concept, it is claimed that some individuals, such as first degree relatives of patients with OCD [63] and OCD patients whose symptoms improved following successful pharmacological treatment [64], demonstrated impairments on selective neuropsychological tasks and could therefore be vulnerable because co…”
BackgroundFornaro, S., & Vallesi, A. (2024) · Current Psychology · doi:10.1007/s12144-023-04312-x · Cited by 21
Imbalance between the caudate and putamen connectivity in obsessive–compulsive disorder
Peng, Z., He, T., Ren, P., Jin, L., Yang, Q., Xu, C., Wen, R., Chen, J., Wei, Z., Verguts, T., et al. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.103083 · Cited by 20
Yazdi‐Ravandi, S., Shamsaei, F., Matinnia, N., Moghimbeigi, A., Shams, J., Ahmadpanah, M., & Ghaleiha, A. (2018) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2018.09.002 · Cited by 20
Hampshire, A., Zadel, A., Sandrone, S., Soreq, E., Fineberg, N. A., Bullmore, E. T., Robbins, T. W., Sahakian, B. J., & Chamberlain, S. R. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.09.010 · Cited by 21
Self-citationVandborg, S. K., Hartmann, T. B., Bennedsen, B. E., Pedersen, A. D., & Thomsen, P. H. (2015) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2014.981649 · Cited by 19
Kashyap, H., Reddy, P., Mandadi, S., Narayanaswamy, J. C., Sudhir, P. M., & Reddy, Y. C. J. (2019) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2019.100480 · Cited by 19
Clarke, A. T., Fineberg, N. A., Pellegrini, L., & Laws, K. R. (2024) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2024.152491 · Cited by 22
Self-citationSánchez-Kuhn, A., León, J. J., Gôngora, K., Pérez-Fernández, C., Sánchez-Santed, F., Moreno, M., & Flores, P. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.07.064 · Cited by 19
Fontenelle, L. F., Oldenhof, E., Moreira‐de‐Oliveira, M. E., Abramowitz, J. S., Antony, M. M., Cath, D. C., Carter, A., Dougherty, D. D., Ferrão, Y. A., Figee, M., et al. (2020) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420912327 · Cited by 22
Li, B., Sun, J.-H., Li, T., & Yang, Y.-C. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1262-2 · Cited by 18
Brožka, H., Radostová, D., Pištíková, A., Valeš, K., & Stuchlík, A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00122 · Cited by 18
Dell’Osso, L., Nardi, B., Bonelli, C., Amatori, G., Pereyra, M. A., Massimetti, E., Cremone, I. M., Pini, S., & Carpita, B. (2024) · Brain Sciences · doi:10.3390/brainsci14010064 · Cited by 19
Family history of substance use disorders: Significance for mental health in young adults who gamble
Grant, J. E., & Chamberlain, S. R. (2020) · Journal of Behavioral Addictions · doi:10.1556/2006.2020.00017 · Cited by 18
Self-citationTowards a computational psychiatry of juvenile obsessive-compulsive disorder
Loosen, A. M., & Hauser, T. U. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.021 · Cited by 19
Kloft, L., Reuter, B., Riesel, A., & Kathmann, N. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0331-x · Cited by 18
Xu, T., Gu, Q., Zhao, Q., Wang, P., Liu, Q., Fan, Q., Chen, J., & Wang, Z. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.037 · Cited by 17
Gorka, S. M., Lieberman, L., Shankman, S. A., & Phan, K. L. (2017) · Psychophysiology · doi:10.1111/psyp.12829 · Cited by 18
Ter-Stepanian, M., Grizenko, N., Cornish, K. M., Talwar, V., Mbékou, V., Schmitz, N., & Joober, R. (2017) · PubMed Central · Cited by 17
Habitual versus affective motivations in obsessive-compulsive disorder and alcohol use disorder
Ferreira, G. M., Lee, R. S. C., Piquet‐Pessôa, M., de Menezes, G. B., Moreira‐de‐Oliveira, M. E., Albertella, L., Yücel, M., Cruz, M. D. S., dos Santos‐Ribeiro, S., & Fontenelle, L. F. (2020) · CNS Spectrums · doi:10.1017/s1092852919001706 · Cited by 17
Functional Brain Imaging and OCD
Soriano‐Mas, C. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_203 · Cited by 18
Switching to zebrafish neurobehavioral models: The obsessive–compulsive disorder paradigm
D’Amico, D., Estivill, X., & Terriente, J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.027 · Cited by 18
Suzuki, S., Zhang, X., Dezfouli, A., Braganza, L., Fulcher, B., Parkes, L., Fontenelle, L. F., Harrison, B. J., Murawski, C., Yücel, M., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002031 · Cited by 16
Zmigrod, L., & Robbins, T. W. (2021) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01784 · Cited by 17
Self-citationMethylphenidate significantly improves neurocognitive impairments in children with ADHD
İzmir, S. B. İ., İpçi, M., & Ercan, E. S. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114492 · Cited by 17
Tyagi, H., Apergis-Schoute, A. M., Akram, H., Foltynie, T., Limousin, P. D., Drummond, L. M., Fineberg, N. A., Matthews, K., Jahanshahi, M., Robbins, T. W., et al. (2022) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20105 · Cited by 16
Self-citationNucleus accumbens core and pathogenesis of compulsive checking
Ballester, J., Dvorkin‐Gheva, A., Silva, C., Foster, J. A., & Szechtman, H. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000112 · Cited by 19
Unbalanced fronto-pallidal neurocircuit underlying set shifting in obsessive-compulsive disorder
Kim, T., Kim, M., Jung, W. H., Kwak, Y. B., Moon, S., Lho, S. K., Lee, J., & Kwon, J. S. (2021) · Brain · doi:10.1093/brain/awab483 · Cited by 15
Cognitive effects of focal neuromodulation in neurological and psychiatric disorders
Wiseman, M., Sewell, I. J., Nestor, S. M., Giacobbe, P., Hamani, C., Lipsman, N., & Rabin, J. S. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00291-3 · Cited by 18
Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder
Bernardes, E. T., Saraiva, L. C., Souza, M. D. M. E., Hoexter, M. Q., Chacon, P., Requena, G. D. L., Miguel, E. C., Shavitt, R. G., Polanczyk, G. V., Cappi, C., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02751-5 · Cited by 15
Neurocognitive Endophenotypes of OCD
Vaghi, M. M. S. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_197 · Cited by 17
Dittrich, W. H., Johansen, T., Landrø, N. I., & Fineberg, N. A. (2011) · University of Hertfordshire Research Archive (University of Hertfordshire) · Cited by 15
Self-citationNaftalovich, H., Tauber, N., & Kalanthroff, E. (2020) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2020.102316 · Cited by 14
Li, X., Li, H., Jiang, X., Li, J., Cao, L., Liu, J., Xing, H., Huang, X., & Gong, Q. (2022) · Human Brain Mapping · doi:10.1002/hbm.25794 · Cited by 14
Control dilemma: Evidence of the stability–flexibility trade-off
Qiao, L., Zhang, L., & Chen, A. (2023) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2023.07.002 · Cited by 16
Conte, G., Costanza, C., Novelli, M., Scarselli, V., Arigliani, E., Valente, F., Baglioni, V., Terrinoni, A., Chiarotti, F., & Cardona, F. (2024) · Children · doi:10.3390/children11020226 · Cited by 14
Lei, H., Cui, Y., Fan, J., Zhang, X., Zhong, M., Yi, J., Cai, L., Yao, D., & Zhu, X. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.05.032 · Cited by 14
Bugalho, P., & Oliveira-Maia, A. J. (2013) · Behavioural Neurology · doi:10.1155/2013/826742 · Cited by 15
Neurobehavioral assessment in forensic practice
Woods, G. W., Freedman, D., & Greenspan, S. (2012) · International Journal of Law and Psychiatry · doi:10.1016/j.ijlp.2012.09.014 · Cited by 14
Medeiros, G. C., & Grant, J. E. (2018) · Journal of Behavioral Addictions · doi:10.1556/2006.7.2018.50 · Cited by 14
Kasparbauer, A., Merten, N., Aichert, D. S., Wöstmann, N. M., Meindl, T., Rujescu, D., & Ettinger, U. (2015) · Cortex · doi:10.1016/j.cortex.2015.07.002 · Cited by 19
Löchner, C., Chamberlain, S. R., Kidd, M., Fineberg, N. A., & Stein, D. J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4172-y · Cited by 13
Self-citationDèttore, D., & O’Connor, K. P. (2012) · Cognitive Therapy and Research · doi:10.1007/s10608-012-9440-0 · Cited by 13
Pediatric OCD in the era of RDoC
Garnaat, S. L., Conelea, C. A., McLaughlin, N. C. R., & Benito, K. (2018) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2018.03.002 · Cited by 13
Lee, D., Baek, J. H., Ha, K., Cho, E.-Y., Choi, Y., Yang, S.-Y., Kim, J. S., Cho, Y., Won, H.-H., & Hong, K. S. (2022) · International Journal of Bipolar Disorders · doi:10.1186/s40345-022-00251-x · Cited by 12
Neural Correlates of Executive Functioning in Anorexia Nervosa and Obsessive–Compulsive Disorder
Thomas, K. S., Birch, R. E., Jones, C. R. G., & Vanderwert, R. E. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.841633 · Cited by 14
Canu, D., Ioannou, C., Müller, K., Martin, B., Fleischhaker, C., Biscaldi, M., Beauducel, A., Smyrnis, N., van Elst, L. T., & Klein, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-19661-z · Cited by 12
Kertzman, S., Poyurovsky, M., Faragian, S., Weizman, R., Cohen, K., Aizer, A., Weizman, A., & Dannon, P. N. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00652 · Cited by 13
Xu, H., Zhang, X., & Bai, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092484 · Cited by 11
Baykal, S., Karabekiroğlu, K., Şenses, A., Karakurt, M. N., Çalik, T., & Yüce, M. (2014) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2014.6862 · Cited by 11
The unique roles of affect and impulsivity in the prediction of skin picking severity
Adams, T. G. (2012) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2012.03.003 · Cited by 11
Muller, J. D. L., Torquato, K. I., Manfro, G. G., & Trentini, C. M. (2015) · Dementia & Neuropsychologia · doi:10.1590/1980-57642015dn93000012 · Cited by 10
Cognitive Training in Obsessive-Compulsive Disorder: A Systematic Review
Bhattacharya, M., Kashyap, H., & Reddy, Y. C. J. (2023) · Indian Journal of Psychological Medicine · doi:10.1177/02537176231207781 · Cited by 10
Grassi, G., Figee, M., Stratta, P., Rossi, A., & Pallanti, S. (2016) · Journal of Behavioral Addictions · doi:10.1556/2006.5.2016.069 · Cited by 11
Grant, J. E., & Chamberlain, S. R. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.06.003 · Cited by 10
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Robbins, T. W. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.005 · Cited by 10
Self-citationZhang, X., Liu, S., & Chen, Z. S. (2021) · iScience · doi:10.1016/j.isci.2021.102919 · Cited by 10
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Pruneti, C. A., Coscioni, G., & Guidotti, S. (2023) · Nutrients · doi:10.3390/nu15030755 · Cited by 9
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Tubío-Fungueiriño, M., Cernadas, E., Fernández-Delgado, M., Arrojo, M., Bertolín, S., Real, E., Menchón, J. M., Carracedo, Á., Alonso, P., Fernández‐Prieto, M., et al. (2024) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.sjpmh.2024.11.001 · Cited by 9
Ma, X., Megli, A., Pittenger, C., & Pushkarskaya, H. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.687680 · Cited by 9
van der Vlis, T. A. M. B., Duits, A., van de Veerdonk, M. M. G. H., Mulders, A. E. P., Schruers, K. R. J., Temel, Y., Ackermans, L. P. C. M., & Leentjens, A. F. G. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13534 · Cited by 9
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de Almeida, K. M., Nery, F. G., Moreno, R. A., Gorenstein, C., & Lafer, B. (2013) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2013.05.019 · Cited by 9
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Schwieler, L., Weidenfors, J. A., Griška, V., Li, X., Piehl, F., Mickienė, A., & Erhardt, S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01485-0 · Cited by 9
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Self-citationWang, J., Huang, C., Luo, G., Xiao, Y., Guo, G., Quan, D., & Zheng, H. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.03.006 · Cited by 8
Rempel, S., Backhausen, L. L., McDonald, M., Roessner, V., Vetter, N. C., Beste, C., & Wolff, N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072486 · Cited by 9
Reid, J. E., Pellegrini, L., Drummond, L. M., Varlakova, Y., Shahper, S., Baldwin, D. S., Manson, C., Chamberlain, S. R., Robbins, T. W., Wellsted, D. M., et al. (2024) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000548 · Cited by 8
Self-citationYan, H., Shan, X., Li, H., Liu, F., Xie, G., Li, P., & Guo, W. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.07.040 · Cited by 8
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Arnold, P. D., & Taillefer, S. E. (2011) · Springer eBooks · doi:10.1007/978-1-4419-7784-7_5 · Cited by 8
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Martoni, R. M., Risso, G., Giuliani, M., Filippis, R. D., Cammino, S., Cavallini, M. C., & Bellodi, L. (2018) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617718000267 · Cited by 8
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Xu, C., Chen, J., Cui, Z., Wen, R., Han, H., Jin, L., Wan, G., Wei, Z., & Peng, Z. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s268148 · Cited by 8
Namlı, Z., Tamam, L., Demirkol, M. E., Karaytuğ, M. O., & Sun, T. (2022) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001601 · Cited by 8
Harkin, B., & Kessler, K. (2012) · Depression and Anxiety · doi:10.1002/da.21911 · Cited by 9
Kubera, K. M., Hirjak, D., Wolf, N. D., Sambataro, F., Thomann, P. A., & Wolf, R. C. (2017) · Brain Topography · doi:10.1007/s10548-017-0604-9 · Cited by 9
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Dupuy, M., Rouillon, F., & Bungener, C. (2012) · L Encéphale · doi:10.1016/j.encep.2012.06.016 · Cited by 9
Skvortsova, V., & Hauser, T. U. (2022) · Research Square · doi:10.21203/rs.3.rs-1280535/v1 · Cited by 9
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Manssuer, L. R., Ding, Q., Feng, Y., Yang, R., Liu, W., Sun, B., Zhan, S., & Voon, V. (2024) · Nature Communications · doi:10.1038/s41467-024-53521-w · Cited by 7
Metadata
- Authors
- Chamberlain, S. R., Fineberg, N. A., Menzies, L. A., Blackwell, A. D., Bullmore, E. T., Robbins, T. W., & Sahakian, B. J.
- Affiliations
- University of Cambridge (GB)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2007-02
- Volume
- 164
- Issue
- 2
- Pages
- 335-338
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC1892796
- OpenAlex
- W2105875973
- Cited by
- 438
- References
- 19
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 30 · 2023: 17 · 2022: 28 · 2021: 31 · 2020: 20 · 2019: 28 · 2018: 19 · 2017: 22 · 2016: 18 · 2015: 33 · 2014: 30 · 2013: 29 · 2012: 24
- FWCI
- 22.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Wellcome Trust (076244, 076274/Z04/Z)
- Medical Research Council
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- obsessive-compulsive disorder, cognitive flexibility, cognitive endophenotypes, motor inhibition, motor impulsivity, first-degree relatives, genetic susceptibility, inhibitory control, set-shifting, stop-signal reaction time, decision-making, genotype-phenotype correlation
- MeSH terms
- Adult, Cognition Disorders, Compulsive Behavior, Decision Making, Family Health, Female, Genetic Markers, Genotype, Humans, Inhibition, Psychological, Male, Motor Activity, Neuropsychological Tests, Obsessive-Compulsive Disorder, Pedigree, Phenotype, Psychomotor Performance, Reaction Time
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