Impaired cortico-striatal functional connectivity is related to trait impulsivity in unmedicated patients with obsessive-compulsive disorder
Abstract
Objectives Convergent evidence has demonstrated that trait impulsivity, a key feature in obsessive-compulsive disorder (OCD), involves dysregulated frontal-striatal circuits. The present study aims to explore relationships between frontal-striatal circuits, trait impulsivity, and obsessive-compulsive symptoms. Methods Thirty-six unmedicated patients with OCD and 50 healthy controls (HCs) matched for age, sex, and years of education underwent a magnetic resonance imaging (MRI) procedure. Voxel-wise statistical parametric analysis was used to investigate the differences in resting-state functional connectivity between brain regions functionally connected to six pairs of a-priori defined striatal seed regions, between patients with OCD and HCs. Associations between frontal-striatal connectivity and both trait impulsivity and symptom severity of OCD were analyzed. Results The results showed altered striatal functional connectivity in OCD group compared to HCs, including increased connectivity of dorsal caudate (DC)-orbitofrontal cortex (OFC), ventral striatum (VS)-OFC, VS-medial prefrontal cortex, and putamen-sensorimotor area, and decreased functional connectivity of DC-anterior cingulate cortex (ACC), putamen-ACC, and putamen-dorsolateral prefrontal cortex (DLPFC). Furthermore, the putamen-DLPFC connectivity was negatively correlated with attentional impulsivity in the OCD group, but showed a positive correlation in HCs. Conclusions The present findings suggested that dorsal co…
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Many studies have indicated cortico-striatal network dysregulation is linked to psychotic symptoms, symptom severity, and response to antipsychotic treatment.
“insofar as many studies have indicated cortico-striatal network dysregulation is linked to psychotic symptoms [60], symptom severity [61], and response to antipsychotic treatment [62].”
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“…in neuropsychiatric disorders of brain network dysconnectivity and failures of neural integration [57 – 59] insofar as many studies have indicated cortico-striatal network dysregulation is linked to psychotic symptoms [60], symptom severity [61], and response to antipsychotic treatment [62].”
Background
- Authors
- Xu, T., Gu, Q., Zhao, Q., Wang, P., Liu, Q., Fan, Q., Chen, J., & Wang, Z.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Wang, Zhen
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 281
- Pages
- 899-907
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W3104649132
- Cited by
- 17
- References
- 9
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 2
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- obsessive-compulsive disorder, trait impulsivity, resting-state functional connectivity, dorsal caudate, orbitofrontal cortex, ventral striatum, putamen, dorsolateral prefrontal cortex, anterior cingulate cortex, attentional impulsivity, inhibitory control, unmedicated patients, symptom severity
- MeSH terms
- Brain Mapping, Corpus Striatum, Humans, Impulsive Behavior, Magnetic Resonance Imaging, Neural Pathways, Obsessive-Compulsive Disorder, Case-Control Studies
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