Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores
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Abstract Background Bipolar disorder (BD) has the greatest suicide risk among mental and physical disorders. A recent genome-wide association study (GWAS) of European ancestry (EUR) samples revealed that the genetic etiology of suicide attempt (SA) was not only polygenic but also, in part, diagnosis-specific. The authors aimed to examine whether the polygenic risk score (PRS) for SA derived from that study is associated with SA or repeated attempts in Korean patients with BD. This study also investigated the shared heritability of SA and mental disorders which showed an increased risk of SA and a high genetic correlation with BD. Methods The study participants were 383 patients with BD. The history of SA was assessed on a lifetime basis. PRSs for reference disorders were calculated using the aforementioned GWAS data for SA and the Psychiatric Genomics Consortium data of BD, schizophrenia, major depressive disorder (MDD), and obsessive–compulsive disorder (OCD). Results The PRS for SA was significantly associated with lifetime SA in the current subjects (Nagelkerke’s R 2 = 2.73%, odds ratio [OR] = 1.36, p = 0.007). Among other PRSs, only the PRS for OCD was significantly associated with lifetime SA (Nagelkerke’s R 2 = 2.72%, OR = 1.36, p = 0.007). The PRS for OCD was higher in multiple attempters than in single attempters (Nagelkerke’s R 2 = 4.91%, OR = 1.53, p = 0.043). Conclusion The PRS for SA derived from EUR data was generalized to SA in Korean patients with BD. The PRS for OCD seemed to affect repeated attempts. Genetic studies on suicide could benefit from focusing on specific psychiatric diagnoses and refined sub-phenotypes, as well as from utilizing multiple PRSs for related disorders.
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Some studies suggest bipolar disorder polygenic risk scores may correlate with suicide attempts, though effect sizes and adjustment for covariates vary and no robust large-scale estimate has been consistently replicated.
“Additionally, some studies suggest bipolar disorder PRS may correlate with suicide attempts, though effect sizes and adjustment for covariates vary and no robust large-scale estimate has been consistently replicated (42)”
From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [42]
The Results (no page given) report a small, nonsignificant association between bipolar-disorder PRS and lifetime suicide attempt (OR 1.16, p = 0.173); the adjusted five-PRS model is also nonsignificant. The Discussion says this null finding corroborates a previous study and calls for larger samples. Thus the paper supports the claim’s caution about uncertain estimates, but not its suggestion that studies have found a bipolar-disorder PRS association; its significant PRS findings concern suicide-attempt and OCD scores instead. (LLM, conf=0.83)
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Salehi, M., Saeidi, M., Amanat, M., Barias, T., Anyeji, U., Alzein, O., & Gunturu, S. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1738009
“…correlate with suicide attempts, though effect sizes and adjustment for covariates vary and no robust large-scale estimate has been consistently replicated (42) PRS for ADHD and autism spectrum disorder (ASD) also showed positive associations with suicidal ideation in children and adolescents (43).”
Abordagem profissional e o comportamento suicida na Atenção Primária à Saúde
Negrão, A. I. D. O., Domingos, T. D. S., Frangonari, T. F., & Horta, A. L. D. M. (2024) · Acta Paulista de Enfermagem · doi:10.37689/acta-ape/2024ao0001005
Gao, B., Zhou, J., Song, B., Wang, M., Shou, R., Qiu, Y., & Zhang, J. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08189-5
Kim, T. H., & Nam, B. (2026) · Springer eBooks · doi:10.1007/978-981-92-1331-3_17
- Authors
- Lee, D., Baek, J. H., Ha, K., Cho, E.-Y., Choi, Y., Yang, S.-Y., Kim, J. S., Cho, Y., Won, H.-H., & Hong, K. S.
- Affiliations
- Samsung Medical Center (KR)
- Seoul National University (KR)
- Samsung (South Korea) (KR)
- Soonchunhyang University (KR)
- Corresponding author
- Baek, Ji Hyun
- Hong, Kyung Sue
- ORCID
- Venue
- International Journal of Bipolar Disorders
- Published
- 2022-02-03
- Volume
- 10
- Issue
- 1
- Pages
- 3-3
- ISSN
- 2194-7511 (ISSN-L)
- PMC
- PMC8811109
- OpenAlex
- W4210340879
- Cited by
- 12
- References
- 74
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Bipolar Disorders (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2019M3C7A1030624, 2019R1G1A109167912)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- bipolar disorder, suicide attempts, repeated suicide attempts, polygenic risk score, genetic architecture, Korean patients, obsessive-compulsive disorder, genetic correlation, shared heritability, mental illness
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