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Cited by 248Schizophrenia research and treatmentHallucinations in medical conditionsNeural dynamics and brain function

The DOI matches its Crossref record; 12 of the 40 references it cites were found in a registry or an index, and 28 are not checked yet.

Synch Before You Speak: Auditory Hallucinations in Schizophrenia

Ford, Judith M., Roach, Brian J., Faustman, William O., Mathalon, Daniel H.·2007·American Journal of Psychiatry
DOI 10.1176/ajp.2007.164.3.458
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Abstract

OBJECTIVE: Synchronization of neural activity preceding self-generated actions may reflect the operation of the forward model, which acts to dampen sensations resulting from those actions. If this is true, pre-action synchrony should be related to subsequent sensory suppression. Deficits in this mechanism may be characteristic of schizophrenia and related to positive symptoms, such as auditory hallucinations. If so, schizophrenia patients should have reduced neural synchrony preceding movements, especially patients with severe hallucinations. METHOD: In 24 patients with schizophrenia or schizoaffective disorder and 25 healthy comparison subjects, the authors related prespeech neural synchrony to subsequent auditory cortical responsiveness to the spoken sound, compared prespeech neural synchrony in schizophrenia patients and healthy comparison subjects, and related prespeech neural synchrony to auditory hallucination severity in patients. To assess neural synchrony, phase coherence of single-trial EEG preceding talking was calculated at a single site across repeated trials. To assess auditory cortical suppression, the N1 event-related brain potentials to speech sound onset during talking and listening were compared. RESULTS: In healthy comparison subjects, prespeech neural synchrony was related to subsequent suppression of responsiveness to the spoken sound, as reflected in reduction of N1 during talking relative to listening. There was greater prespeech synchrony in comparison subjects than in patients, especially those with severe auditory hallucinations. CONCLUSIONS: These data suggest that EEG synchrony preceding speech reflects the action of a forward model system, which dampens auditory responsiveness to self-generated speech and is deficient in patients who hallucinate.

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Research works printed but not linked: 6

  1. Helmholtz H, 1925, Optical Society of America, vol III, 44
  2. Friston KJ, 1995, Clin Neurosci, 3, 89
  3. Heinks-Maldonado TH, Gray E
  4. Andreasen NC, 1983, Scale for the Assessment of Negative Symptoms (SANS). Iowa City
  5. Andreasen NC, 1984, Scale for the Assessment of Positive Symptoms (SAPS). Iowa City
  6. Keppel G, 1991, Design and Analysis: A Researcher's Handbook

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Metadata

Authors
Ford, J. M., Roach, B. J., Faustman, W. O., & Mathalon, D. H.
Affiliations
VA Connecticut Healthcare System (US)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2007-03
Volume
164
Issue
3
Pages
458-466
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.2007.164.3.458
OpenAlex
W2014504186
Semantic Scholar
d5578f7ae1c175a0e407e33e7036a0549403a43c
Cited by
245
References
40
Citations by year
2026: 8 · 2025: 12 · 2024: 11 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 12 · 2014: 14 · 2013: 13 · 2012: 24
FWCI
11.86
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh058262-17)
  • National Institute of Mental Health (MH067967, K02MH067967, MH-58262, R01MH-058262)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
auditory hallucinations, schizophrenia, forward model, sensory suppression, N1 event-related potential, phase coherence, schizoaffective disorder, positive symptoms
MeSH terms
Adult, Auditory Cortex, Auditory Perception, Cortical Synchronization, Electroencephalography, Evoked Potentials, Auditory, Female, Hallucinations, Humans, Male, Models, Neurological, Schizophrenia, Schizophrenic Psychology, Speech, Speech Perception

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