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Synch Before You Speak: Auditory Hallucinations in Schizophrenia
Abstract
OBJECTIVE: Synchronization of neural activity preceding self-generated actions may reflect the operation of the forward model, which acts to dampen sensations resulting from those actions. If this is true, pre-action synchrony should be related to subsequent sensory suppression. Deficits in this mechanism may be characteristic of schizophrenia and related to positive symptoms, such as auditory hallucinations. If so, schizophrenia patients should have reduced neural synchrony preceding movements, especially patients with severe hallucinations. METHOD: In 24 patients with schizophrenia or schizoaffective disorder and 25 healthy comparison subjects, the authors related prespeech neural synchrony to subsequent auditory cortical responsiveness to the spoken sound, compared prespeech neural synchrony in schizophrenia patients and healthy comparison subjects, and related prespeech neural synchrony to auditory hallucination severity in patients. To assess neural synchrony, phase coherence of single-trial EEG preceding talking was calculated at a single site across repeated trials. To assess auditory cortical suppression, the N1 event-related brain potentials to speech sound onset during talking and listening were compared. RESULTS: In healthy comparison subjects, prespeech neural synchrony was related to subsequent suppression of responsiveness to the spoken sound, as reflected in reduction of N1 during talking relative to listening. There was greater prespeech synchrony in comparison subjects than in patients, especially those with severe auditory hallucinations. CONCLUSIONS: These data suggest that EEG synchrony preceding speech reflects the action of a forward model system, which dampens auditory responsiveness to self-generated speech and is deficient in patients who hallucinate.
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“in line with the “comparator model” theory, positing that AHs are related to inner-speech self-monitoring impairments.[37][38][39]”
From Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain? (2016) · cites this paper as [38]
In the citing paper
“This hypothesis is supported by studies showing non-suppression of the N100 event-related potential and impaired pre-speech inter-trial electroencephalographic (EEG) coherence in patients with AVHs (6,7).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [7]
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“It has been shown that the synchronization of activity in brain areas that are associated with self-produced speech is attenuated in people with schizophrenia, and that this strongly predicts their likelihood of experiencing hallucination”
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“A similar aberrant efference copy account has been made with respect to auditory hallucinations (Ford and Mathalon, 2005; Ford et al., 2007; HeinksMaldonado et al., 2007).”
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“In this review we have attempted to identify some points of contact between psychology and neuroscience, for example research suggesting that impaired communication between the frontal speech-generating areas and the auditory cortex may play a role in the source monitoring difficulties of hallucinating patients [121,…”
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Self-citationInteraction of language, auditory and memory brain networks in auditory verbal hallucinations
Ćurčić-Blake, B., Ford, J. M., Hubl, D., Orlov, N. D., Sommer, I. E., Waters, F., Allen, P., Jardri, R., Woodruff, P. W., David, O., et al. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.11.002 · Cited by 224
“suppression, as the degree of connectivity between these areas during talking is related to the degree of suppression (Ford et al., 2007; Chen et al., 2011; Wang et al., 2014).”
BackgroundSelf-citationDid I do that? Abnormal predictive processes in schizophrenia when button pressing to deliver a tone
Ford, J. M., Palzes, V. A., Roach, B. J., & Mathalon, D. H. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt072 · Cited by 210
Self-citationNorthoff, G., & Qin, P. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.11.009 · Cited by 209
“…between sensory and motor processing and thus abnormal corollary discharge with a consecutive mismatch between the predicted or anticipated auditory consequences of self-generated speech and the actual auditory experience (Bennett, 2008; Feinberg and Guazzelli, 1999; Ford et al., 2002, 2007, 2008).”
BackgroundThe hodology of hallucinations
Ffytche, D. H. (2008) · Cortex · doi:10.1016/j.cortex.2008.04.005 · Cited by 206
“The same group has also demonstrated decreased intertrial coherence in hallucinators specific to talking (a measure of local synchrony thought to signify feed-forward efference signals) (Ford et al., 2007).”
BackgroundHigh-frequency oscillations and the neurobiology of schizophrenia
Uhlhaas, P. J., & Singer, W. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.3/puhlhaas · Cited by 206
“Further evidence for an involvement of disturbed betaband oscillations in cognitive deficits in SCZ was reported by Ford and colleagues.(57) The authors hypothesized that SCZ patients may fail to adequately predict the causes of sensory perception which could, for example, lead to self-generated speech acts being assi…”
BackgroundDissecting corollary discharge dysfunction in schizophrenia
Ford, J. M., Gray, M., Faustman, W. O., Roach, B. J., & Mathalon, D. H. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00533.x · Cited by 192
Self-citationAre hallucinations due to an imbalance between excitatory and inhibitory influences on the brain?
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Reduced Natural Oscillatory Frequency of Frontal Thalamocortical Circuits in Schizophrenia
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“In a study comparing neural activity immediately preceding self-generated speech and listening, patients with schizophrenia failed toshowanincrease in frontalbeta-bandsynchronization (intertrial coherence [ITC]) in the prespeech vs listening condition, and this synchronization deficit was inversely related to hallucin…”
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“This hypothesis is supported by studies showing non-suppression of the N100 event-related potential and impaired prespeech inter-trial electroencephalographic (EEG) coherence in patients with AVHs (6,7).”
ResultPrediction error, ketamine and psychosis: An updated model
Corlett, P. R., Honey, G. D., & Fletcher, P. C. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116650087 · Cited by 142
Ouhaz, Z., Fleming, H., & Mitchell, A. S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00033 · Cited by 142
“An intriguing result also comes from Ford and colleagues (Ford et al., 2007), who reported that the increase in beta-band synchrony usually observed in healthy participants immediately prior to self-generated speech (as opposed to when listening to a recording of themselves speak) is reduced in schizophrenia patients,…”
BackgroundOut-of-synch and out-of-sorts: dysfunction of motor-sensory communication in schizophrenia
Ford, J. M., Roach, B. J., Faustman, W. O., & Mathalon, D. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.013 · Cited by 136
“Notwithstanding the findings of others(16), our failure to find a relationship between auditory hallucinations and forward model-related signals in the sensorimotor system, coupled with our recent findings of such relationships when measures were obtained during talking(14), suggests that there may be some modality-sp…”
BackgroundResultInfluentialSelf-citationSteeds, H., Carhart-Harris, R. L., & Stone, J. M. (2014) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125314557797 · Cited by 143
Lange, K. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00263 · Cited by 148
“…et al., 2002; Heinks-Maldonado et al., 2005, 2006; Martikainen et al., 2005; Bäß et al., 2008; Aliu et al., 2009; Lange, 2011) or by temporally predictable auditory stimuli (e.g., Schafer et al., 1981; Clementz et al., 2002; Ford et al., 2007; Lange, 2009; see also Vroomen and Stekelenburg, 2010)1.”
BackgroundResultThe brain’s voices: comparing nonclinical auditory hallucinations and imagery
Linden, D. E. J., Thornton, K., Kuswanto, C. N., Johnston, S. J., van de Ven, V., & Jackson, M. C. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq097 · Cited by 117
Takahashi, H., Rissling, A. J., Pascual-Marqui, R. D., Kirihara, K., Pela, M., Sprock, J., BRAFF, D. L., & Light, G. A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.074 · Cited by 117
Anticipating the future: Automatic prediction failures in schizophrenia
Ford, J. M., & Mathalon, D. H. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.09.004 · Cited by 113
Self-citationInsights into Cortical Oscillations Arising from Optogenetic Studies
Sohal, V. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.024 · Cited by 118
“In some cases, these abnormalities correlate with the severity of cognitive dysfunction or other symptoms (25, 28).”
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Cortical Oscillations in Health and Disease
Traub, R. D., & Whittington, M. A. (2010) · doi:10.1093/acprof:oso/9780195342796.001.0001 · Cited by 108
Salisbury, D. F., Collins, K., & McCarley, R. W. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp003 · Cited by 105
Neurophysiological Studies of Auditory Verbal Hallucinations
Ford, J. M., Dierks, T., Fisher, D. J., Herrmann, C. S., Hubl, D., Kindler, J., Koenig, T. W., Mathalon, D. H., Spencer, K., Strik, W. K., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs009 · Cited by 97
Self-citationAttenuation of auditory N 1 results from identity‐specific action‐effect prediction
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“Given the almost exclusive use of the comparison between self- and externally-triggered tones for studying sensory attenuation in schizophrenia (e.g. Ford et al., 2001, 2007a,b), the current study may have important implications for allowing future research to more precisely determine processes…”
BackgroundMethodAssessing corollary discharge in humans using noninvasive neurophysiological methods
Ford, J. M., Roach, B. J., & Mathalon, D. H. (2010) · Nature Protocols · doi:10.1038/nprot.2010.67 · Cited by 92
Self-citationde Weijer, A. D., Mandl, R. C. W., Diederen, K. M. J., Neggers, S. F. W., Kahn, R. S., Pol, H. E. H., & Sommer, I. E. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.05.010 · Cited by 101
Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications
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Functional magnetic resonance imaging of inner speech in schizophrenia
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“…decreases in the power or synchrony of gamma oscillations during responses to sensory stimulation or cognitive tasks (Gallinat et al., 2004; Spencer et al., 2004; Symond et al., 2005; Wynn et al., 2005; Cho et al., 2006; Ford et al., 2007, 2008; Haenschel et al., 2009; Uhlhaas and Singer, 2010).”
BackgroundAction planning and predictive coding when speaking
Wang, J., Mathalon, D. H., Roach, B. J., Reilly, J. L., Keedy, S., Sweeney, J. A., & Ford, J. M. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.003 · Cited by 95
“…to self-generated sounds, with some studies 97 showing suppression (Greenlee et al., 2013; Houde et al., 2002; 98 Knollea et al., 2013) and some not (Baess et al., 2008; Behroozmand 99 and Larson, 2011; Martikainen et al., 2005) and many not reporting P2 100 data at all (e.g. (Ford et al., 2007a)).”
Self-citationReznik, D., Henkin, Y., Schadel, N., & Mukamel, R. (2014) · Nature Communications · doi:10.1038/ncomms5059 · Cited by 90
Time-dependent Neural Processing of Auditory Feedback during Voice Pitch Error Detection
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The dependence of P300 amplitude on gamma synchrony breaks down in schizophrenia
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“The breakdown of a lawful relationship among neurobiological (Ford et al., 2007) or neuropsychological (Sullivan et al.”
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“It is proposed [Feinberg, 1978; Ford et al., 2007; Frith, 1992] that a malfunction of the corollary discharge system to underlies the failure to recognize self-produced verbal fragments [Whitford et al.”
BackgroundSensory prediction errors in the continuum of psychosis
Randeniya, R., Oestreich, L. K. L., & Garrido, M. I. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.019 · Cited by 78
“Patients with schizophrenia demonstrate deficits in prediction of both external stimuli (Erickson et al., 2016; Fisher et al., 2012; Todd et al., 2008) and selfgenerated stimuli (Ford et al., 2007a; Ford and Mathalon, 2012; Ford et al., 2014).”
BackgroundInfluentialHoffman, R. E., Varanko, M., Gilmore, J., & Mishara, A. L. (2008) · Psychological Medicine · doi:10.1017/s0033291707002395 · Cited by 79
“…support models of AVHs postulating activation involving the auditory cortex or adjacent cortical areas (David, 1994; Dierks et al. 1999 ; Hubl et al. 2007), or corollary discharge failures causing disinhibition of sensory qualities of inner speech (Feinberg & Guazzelli, 1999 ; Ford et al. 2007).”
BackgroundInfluentialFord, J. M., Mathalon, D. H., Roach, B. J., Keedy, S., Reilly, J. L., Gershon, E. S., & Sweeney, J. A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs129 · Cited by 83
Self-citationThe corollary discharge in humans is related to synchronous neural oscillations
Chen, C.-M. A., Mathalon, D. H., Roach, B. J., Cavus, I., Spencer, D. D., & Ford, J. M. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21589 · Cited by 86
“Indeed, previous work from our laboratory using scalp-recorded electrophysiological responses (Ford et al., 2007) suggests that a copy of the speech plan precedes speech onset and may work to dampen the auditory cortical response to that speech in healthy participants.”
BackgroundSelf-citationDeficient multisensory integration in schizophrenia: An event-related potential study
Stekelenburg, J. J., Maes, J. P., Gool, A. R. V., Sitskoorn, M. M., & Vroomen, J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.04.038 · Cited by 74
“In line with this, it has been reported that the dampening of the auditory N1 observed in control subjects to self-initiated sounds was not evident in patients with schizophrenia (Ford et al., 2007).”
Oestreich, L., Mifsud, N. G., Ford, J. M., Roach, B. J., Mathalon, D. H., & Whitford, T. J. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.05.014 · Cited by 83
“The protocol for the Talk and Listen conditions were based on the previously published protocol by Ford et al. (2010), while the protocol for the Cued Listen condition was a refinement of the protocol used by Ford et al. (2007a).”
BackgroundMethodResultInfluentialSelf-citationFunctional connectivity studies of patients with auditory verbal hallucinations
Hoffman, R. E., & Hampson, M. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00006 · Cited by 72
“…of inner speech misidentified as non-self-due to a disruption of frontotemporal efference copy projections that ordinarily signal to sensory systems that actions (and thought) are self-generated (Feinberg, 1978; Frith and Done, 1988; Ford et al., 2007; HeinksMaldonado et al., 2007; Jones, 2010).”
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Self-citationBenetti, S., Pettersson‐Yeo, W., Allen, P., Catani, M., Williams, S., Barsaglini, A., Kambeitz‐Ilankovic, L., McGuire, P. K., & Mechelli, A. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt172 · Cited by 67
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“been suggested that synchrony of neural activity (in the gamma or beta range) preceding the action may be the instantiation of the efference copy being sent from motor to sensory areas.(15) Whether it reflects the motor command or the efference copy itself, the neural activity”
BackgroundInfluentialSelf-citationAltered oscillatory alpha and theta networks in schizophrenia
Basar-Eroglu, C., Schmiedt‐Fehr, C., Marbach, S., Brand, A., & Mathes, B. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.114 · Cited by 62
“While patients elicit se locking particularly at anterior locations for the VEP studies reported that the cognitive deficits are attributable to schizophrenia itself rather than medication (Gallinat et al., 2004; Goldberg et al., 1993).”
Corollary Discharge Dysfunction in Schizophrenia: Evidence for an Elemental Deficit
Mathalon, D. H., & Ford, J. M. (2008) · Clinical EEG and Neuroscience · doi:10.1177/155005940803900212 · Cited by 60
Self-citationThe function and failure of sensory predictions
Bansal, S., Ford, J. M., & Spering, M. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13686 · Cited by 66
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Alterations of agency in hypnosis: A new predictive coding model.
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Dickerson, D., Overeem, K. A., Wolff, A. R., Williams, J. M., Abraham, W. C., & Bilkey, D. K. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.64 · Cited by 58
Mathalon, D. H., Roach, B. J., Ferri, J. M., Loewy, R. L., Stuart, B. K., Perez, V. B., Trujillo, T. H., & Ford, J. M. (2018) · Psychological Medicine · doi:10.1017/s0033291718002659 · Cited by 58
“ERP studies have demonstrated that patients with schizophrenia show less suppression of the auditory N1 in response to self-generated vocalization than healthy controls (HCs) (Ford et al., 2001, 2007b; Mathalon and Ford, 2008; Perez et al., 2012).”
BackgroundResultInfluentialSelf-citationBachiller, A., Poza, J., Gómez, C., Molina, V., Suazo, V., & Hornero, R. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/1/016007 · Cited by 55
Impaired action self-monitoring in schizophrenia patients with auditory hallucinations
Gawęda, Ł., Woodward, T. S., Moritz, S., & Kokoszka, A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.12.003 · Cited by 55
“Hyperactivity of superior temporal gyrus (STG), a region involved in speech perception, has been proposed to account for “over-perception” of inner-speech (Ford et al., 2007; Allen et al., 2008; Rapin et al., 2012), enriching vividness of perceptual features associated with inner dialogue (e.”
BackgroundSpeaking-Induced Suppression of the Auditory Cortex in Humans and Its Relevance to Schizophrenia
Whitford, T. J. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.05.011 · Cited by 64
The Cognitive Neuropsychology of Auditory Hallucinations: A Parallel Auditory Pathways Framework
Badcock, J. C. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn128 · Cited by 54
Aberrant resting-state connectivity in non-psychotic individuals with auditory hallucinations
Diederen, K. M. J., Neggers, S. F. W., de Weijer, A. D., van Lutterveld, R., Daalman, K., Eickhoff, S. B., Clos, M., Kahn, R. S., & Sommer, I. E. (2012) · Psychological Medicine · doi:10.1017/s0033291712002541 · Cited by 53
“…to consist of dysfunctional connectivity between frontal and superior temporal regions involved in the production and perception of language (Frith et al. 1995 ; McGuire & Frith, 1996 ; Spence et al. 2000 ; Allen et al. 2007 ; Ford et al. 2007 ; Heinks-Maldonado et al. 2007 ; Shergill et al. 2007).”
BackgroundHallucinations both in and out of context: An active inference account
Benrimoh, D. A., Parr, T., Adams, R. A., & Friston, K. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212379 · Cited by 54
The Neurophysiology of Auditory Hallucinations – A Historical and Contemporary Review
van Lutterveld, R., Sommer, I. E., & Ford, J. M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00028 · Cited by 50
Self-citationAbnormal connectivity between attentional, language and auditory networks in schizophrenia
Liemburg, E. J., Vercammen, A., Horst, G. J. T., Ćurĉić‐Blake, B., Knegtering, H., & Aleman, A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2011.12.003 · Cited by 52
“, 2010), and reduced synchrony during the prespeech phase (Ford et al., 2007) in people with schizophrenia, particularly in those withAVH.”
Role of N-Methyl D-aspartate receptors in action-based predictive coding deficits in schizophrenia
Kort, N. S., Ford, J. M., Roach, B. J., Gunduz-Bruce, H., Krystal, J. H., Jaeger, J., Reinhart, R. M. G., & Mathalon, D. H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.019 · Cited by 48
“Many prior electroencephalographic (EEG) studies found that patients with schizophrenia exhibit reduced suppression of auditory cortical responses, specifically the N1 component of the auditory event-related brain potential (ERP), to self-produced speech sounds (14, 23-25, 40-42).”
Self-citationGallagher, S. (2014) · Review of Philosophy and Psychology · doi:10.1007/s13164-014-0222-3 · Cited by 48
“First, neuroscientific studies support the idea that at least some of the neural processes related to SA are processes that underpin either motor control processes or very basic timing mechanisms that would affect not only movement, but also speaking and thinking; and these processes have been shown to involve abnorma…”
BackgroundImplicit Timing as the Missing Link between Neurobiological and Self Disorders in Schizophrenia?
Giersch, A., Lalanne, L., & Isope, P. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00303 · Cited by 53
“Abnormal corollary discharges have also been suggested for eye movements (Thakkar et al., 2015), speech (Ford et al., 2007) and even simple tones (Ford et al., 2014).”
BackgroundInfluentialStudying auditory verbal hallucinations using the RDoC framework
Ford, J. M. (2016) · Psychophysiology · doi:10.1111/psyp.12457 · Cited by 51
Self-citationFisher, D. J., Smith, D., Labelle, A., & Knott, V. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.05.005 · Cited by 44
Cortical Suppression to Delayed Self-Initiated Auditory Stimuli in Schizotypy
Oestreich, L., Mifsud, N. G., Ford, J. M., Roach, B. J., Mathalon, D. H., & Whitford, T. J. (2015) · Clinical EEG and Neuroscience · doi:10.1177/1550059415581708 · Cited by 57
Self-citationDiminished auditory sensory gating during active auditory verbal hallucinations
Thoma, R. J., Meier, A. M., Houck, J. M., Clark, V. P., Lewine, J. D., Turner, J. A., Calhoun, V. D., & Stephen, J. M. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.01.023 · Cited by 45
“Diminished auditory sensory 17.01.023 Ford et al. (2001, 2007, 2012), suggests that AVH arise from an impaired ability to correctly label auditory verbal processing as either internally self-generated, or as externally generated.”
BackgroundInfluentialGómez‐Pilar, J., Poza, J., Bachiller, A., Gómez, C., Nùñez, P., Lubeiro, A., Molina, V., & Hornero, R. (2017) · International Journal of Neural Systems · doi:10.1142/s0129065717500320 · Cited by 46
Frühholz, S., & Schweinberger, S. R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101948 · Cited by 48
Abnormal processing of emotional prosody in Williams syndrome: An event-related potentials study
Pinheiro, A. P., Galdo‐Álvarez, S., Rauber, A. S., Sampaio, A., Niznikiewicz, M. A., & Gonçalves, Ó. F. (2010) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2010.09.011 · Cited by 43
Whitford, V., O'Driscoll, G. A., Pack, C. C., Joober, R., Malla, A., & Titone, D. (2013) · Journal of Experimental Psychology: General · doi:10.1037/a0028062 · Cited by 42
Attention effects on sensory gating — Intracranial and scalp recordings
Rosburg, T., Trautner, P., Elger, C. E., & Kurthen, M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.063 · Cited by 42
“Alternatively, this amplitude reduction might be regarded as consequence of corollary discharge in the sensory cortex (Ford et al., 2007).”
BackgroundConsequences matter: Self‐induced tones are used as feedback to optimize tone‐eliciting actions
Neszmélyi, B., & Horváth, J. (2017) · Psychophysiology · doi:10.1111/psyp.12845 · Cited by 45
“It has been previously suggested (Ford et al., 2007, 2008) that actions are preceded by neural activity reflecting the instantiation of the efference copy produced by the motor system, which is sent to sensory areas to predict the sensory consequences of the action.”
Efference Copy, Corollary Discharge, Predictive Coding, and Psychosis
Ford, J. M., & Mathalon, D. H. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.07.005 · Cited by 44
Self-citationVoice-selective prediction alterations in nonclinical voice hearers
Pinheiro, A. P., Schwartze, M., & Kotz, S. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32614-9 · Cited by 37
Zhang, M., Force, R. B., Walker, C. P. R., Ahn, S., Jarskog, L. F., & Frӧhlich, F. (2022) · Schizophrenia · doi:10.1038/s41537-022-00321-0 · Cited by 41
Gómez‐Pilar, J., Poza, J., Bachiller, A., Gómez, C., Molina, V., & Hornero, R. (2015) · Entropy · doi:10.3390/e17085241 · Cited by 39
“Thus, following these previous studies, it can be inferred that evoked response produced an increase in the concentration of low-frequency power (mainly around theta band [49]) at the expense of alpha and higher frequencies during the response window [42,48,51].”
BackgroundNeuroimaging of Voice Hearing in Non-Psychotic Individuals: A Mini Review
Diederen, K., van Lutterveld, R., & Sommer, I. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00111 · Cited by 39
“, 2007), dysfunctional connectivity of frontal and temporoparietal language regions (Frith et al., 1995; Spence et al., 2000; Ford et al., 2007; Kühn and Gallinat, 2010), decreases in psychophysiological measures of effortful attention (Havermans et al.”
BackgroundInfluentialNeuroscience‐informed computer‐assisted cognitive training in schizophrenia
Fisher, M., Herman, A. B., Stephens, D. B., & Vinogradov, S. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13042 · Cited by 40
“110,128 133 In our work, we have found that high-gamma activity in temporal and prefrontal cortices correlates with auditory working memory in both healthy subjects and patients with schizophrenia.”
BackgroundSensorimotor Induction of Auditory Misattribution in Early Psychosis
Salomon, R., Progin, P., Griffa, A., Rognini, G., Kim, Q., Conus, P., Marchesotti, S., Bernasconi, F., Hagmann, P., Serino, A., et al. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz136 · Cited by 38
Cerebellar circuitry and auditory verbal hallucinations: An integrative synthesis and perspective
Pinheiro, A. P., Schwartze, M., & Kotz, S. A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.08.004 · Cited by 43
Zhang, Y., Zheng, J., Fan, X., Guo, X., Guo, W., Yang, G., Chen, H., Zhao, J., & Lv, L. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.07.031 · Cited by 38
Yamaguchi, S., Shiozawa, T., Matsunaga, A., Bernick, P. J., Sawada, U., Taneda, A., Osumi, T., & Fujii, C. (2020) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796020000256 · Cited by 33
“This model proposes that the sense of agency can emerge when a prediction of sensory consequence that is implicitly produced based on an efference copy of motor commands matches the actual sensory consequence (Frith et al., 2000).”
BackgroundAssociation between symptoms of psychosis and reduced functional connectivity of auditory cortex
Oertel‐Knöchel, V., Knöchel, C., Matura, S., Stäblein, M., Prvulovic, D., Maurer, K., Linden, D. E. J., & van de Ven, V. G. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.10.036 · Cited by 33
Discovery and development of integrative biological markers for schizophrenia
Oertel‐Knöchel, V., Bittner, R. A., Knöchel, C., Prvulovic, D., & Hampel, H. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.006 · Cited by 33
“They could offer a parsimonious explanation for important aspects of the clinical phenotype such as hallucinations (Ford et al., 2007; Heinks-Maldonado et al., 2007).”
Lavigne, K. M., & Woodward, T. S. (2017) · Human Brain Mapping · doi:10.1002/hbm.23934 · Cited by 32
Sensory Attenuation in the Auditory Modality as a Window Into Predictive Processing
Kiepe, F., Kraus, N., & Hesselmann, G. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.704668 · Cited by 37
Swiney, L., & Sousa, P. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00675 · Cited by 34
Metadata
- Authors
- Ford, J. M., Roach, B. J., Faustman, W. O., & Mathalon, D. H.
- Affiliations
- VA Connecticut Healthcare System (US)
- Venue
- American Journal of Psychiatry
- Published
- 2007-03
- Volume
- 164
- Issue
- 3
- Pages
- 458-466
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2014504186
- Semantic Scholar
- d5578f7ae1c175a0e407e33e7036a0549403a43c
- Cited by
- 245
- References
- 40
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 11 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 12 · 2014: 14 · 2013: 13 · 2012: 24
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh058262-17)
- National Institute of Mental Health (MH067967, K02MH067967, MH-58262, R01MH-058262)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- auditory hallucinations, schizophrenia, forward model, sensory suppression, N1 event-related potential, phase coherence, schizoaffective disorder, positive symptoms
- MeSH terms
- Adult, Auditory Cortex, Auditory Perception, Cortical Synchronization, Electroencephalography, Evoked Potentials, Auditory, Female, Hallucinations, Humans, Male, Models, Neurological, Schizophrenia, Schizophrenic Psychology, Speech, Speech Perception
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