The DOI matches its Crossref record; 12 of the 40 references it cites were found in a registry or an index, and 28 are not checked yet.
Synch Before You Speak: Auditory Hallucinations in Schizophrenia
Abstract
OBJECTIVE: Synchronization of neural activity preceding self-generated actions may reflect the operation of the forward model, which acts to dampen sensations resulting from those actions. If this is true, pre-action synchrony should be related to subsequent sensory suppression. Deficits in this mechanism may be characteristic of schizophrenia and related to positive symptoms, such as auditory hallucinations. If so, schizophrenia patients should have reduced neural synchrony preceding movements, especially patients with severe hallucinations. METHOD: In 24 patients with schizophrenia or schizoaffective disorder and 25 healthy comparison subjects, the authors related prespeech neural synchrony to subsequent auditory cortical responsiveness to the spoken sound, compared prespeech neural synchrony in schizophrenia patients and healthy comparison subjects, and related prespeech neural synchrony to auditory hallucination severity in patients. To assess neural synchrony, phase coherence of single-trial EEG preceding talking was calculated at a single site across repeated trials. To assess auditory cortical suppression, the N1 event-related brain potentials to speech sound onset during talking and listening were compared. RESULTS: In healthy comparison subjects, prespeech neural synchrony was related to subsequent suppression of responsiveness to the spoken sound, as reflected in reduction of N1 during talking relative to listening. There was greater prespeech synchrony in comparison subjects than in patients, especially those with severe auditory hallucinations. CONCLUSIONS: These data suggest that EEG synchrony preceding speech reflects the action of a forward model system, which dampens auditory responsiveness to self-generated speech and is deficient in patients who hallucinate.
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“in line with the “comparator model” theory, positing that AHs are related to inner-speech self-monitoring impairments.[37][38][39]”
From Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain? (2016) · cites this paper as [38]
In the citing paper
“This hypothesis is supported by studies showing non-suppression of the N100 event-related potential and impaired pre-speech inter-trial electroencephalographic (EEG) coherence in patients with AVHs (6,7).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [7]
Citations
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Cited by
Sorted by citations
Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia
Fletcher, P. C., & Frith, C. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2536 · Cited by 1,462
“It has been shown that the synchronization of activity in brain areas that are associated with self-produced speech is attenuated in people with schizophrenia, and that this strongly predicts their likelihood of experiencing hallucination”
BackgroundUhlhaas, P. J., Haenschel, C., Nikolic, D., & Singer, W. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn062 · Cited by 629
Roach, B. J., & Mathalon, D. H. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn093 · Cited by 599
Self-citationHallucinations and strong priors
Corlett, P. R., Horga, G., Fletcher, P. C., Alderson-Day, B., Schmack, K., & Powers, A. R. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.12.001 · Cited by 534
Toward a neurobiology of delusions
Corlett, P. R., Taylor, J. R., Wang, X.-J., Fletcher, P. C., & Krystal, J. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.007 · Cited by 394
“A similar aberrant efference copy account has been made with respect to auditory hallucinations (Ford and Mathalon, 2005; Ford et al., 2007; HeinksMaldonado et al., 2007).”
Background
Metadata
- Authors
- Ford, J. M., Roach, B. J., Faustman, W. O., & Mathalon, D. H.
- Affiliations
- VA Connecticut Healthcare System (US)
- Venue
- American Journal of Psychiatry
- Published
- 2007-03
- Volume
- 164
- Issue
- 3
- Pages
- 458-466
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2014504186
- Semantic Scholar
- d5578f7ae1c175a0e407e33e7036a0549403a43c
- Cited by
- 245
- References
- 40
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 11 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 12 · 2014: 14 · 2013: 13 · 2012: 24
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh058262-17)
- National Institute of Mental Health (MH067967, K02MH067967, MH-58262, R01MH-058262)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- auditory hallucinations, schizophrenia, forward model, sensory suppression, N1 event-related potential, phase coherence, schizoaffective disorder, positive symptoms
- MeSH terms
- Adult, Auditory Cortex, Auditory Perception, Cortical Synchronization, Electroencephalography, Evoked Potentials, Auditory, Female, Hallucinations, Humans, Male, Models, Neurological, Schizophrenia, Schizophrenic Psychology, Speech, Speech Perception
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