The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Anorexia Nervosa and Major Depression: Shared Genetic and Environmental Risk Factors
Abstract
OBJECTIVE: The authors sought to derive heritability estimates for anorexia nervosa and to explore the etiology of the comorbid relationship between anorexia nervosa and major depression. METHOD: They applied bivariate structural equation modeling to a broad definition of anorexia nervosa and lifetime major depression as assessed in a population-based sample of 2,163 female twins. RESULTS: Anorexia nervosa was estimated to have a heritability of 58% (95% confidence interval=33%-84%). The authors were unable to completely rule out a contribution of shared environment. The comorbidity between anorexia nervosa and major depression is likely due to genetic factors that influence the risk for both disorders. CONCLUSIONS: Although the study was limited by the small number of affected twins, the results suggest that genetic factors significantly influence the risk for anorexia nervosa and substantially contribute to the observed comorbidity between anorexia nervosa and major depression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Eating disorders, such as anorexia nervosa (AN), have a significant genetic component.”
From Evidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1 (2002) · cites this paper as Wade et al. 2000
In the citing paper
“In these studies, concordance rates for MZ twins with AN have been estimated to be 52%-56%, whereas concordance rates for DZ twins with AN have been estimated to be 5%-11% (Garfinkel and Garner 1982; Holland et al. 1984, 1988; Wade et al. 2000).”
From Evidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1 (2002) · cites this paper as Wade et al. 2000
In the citing paper
“These studies strongly suggest that the familiality observed in family studies is primarily due to genetic causes.”
From Evidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1 (2002) · cites this paper as Wade et al. 2000
Citations
Cites
The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description
Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336
A Controlled Family Study of Anorexia Nervosa and Bulimia Nervosa
Lilenfeld, L. R., Kaye, W. H., Greeno, C. G., Merikangas, K. R., Plotnicov, K. H., Pollice, C., Rao, R., Strober, M. A., Bulik, C. M., & Nagy, L. M. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.603 · Cited by 599
Self-citationAnorexia nervosa and anorexic-like syndromes in a population-based female twin sample.
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.1.64 · Cited by 332
Self-citationHudson, J. I., & Pope, H. G. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.5.552 · Cited by 249
Twin Studies of Psychiatric Illness: Current Status and Future Directions
Kendler, K. S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820230075007 · Cited by 214
Self-citationRand, C. S. W., & Kuldau, J. M. (1990) · International Journal of Eating Disorders · doi:10.1002/1098-108x(199005)9:3 · Cited by 195
Anorexia nervosa: a study of 34 twin pairs and one set of triplets
Holland, A. J., Hall, A., Murray, R., Russell, G. F. M., & Crisp, A. H. (1984) · British Journal of Psychiatry · doi:10.1192/bjp.145.4.414 · Cited by 174
Depression in anorexia nervosa and bulimia nervosa: discriminating depressive symptoms and episodes
Kennedy, S. H., Kaplan, A. S., Garfinkel, P. E., Rockert, W., Toner, B. B., & Abbey, S. E. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90030-2 · Cited by 85
The involvement of psychosexual factors in the causation of eating disorders: Time for a reappraisal
Scott, D. W. (1987) · International Journal of Eating Disorders · doi:10.1002/1098-108x(198703)6:2 · Cited by 28
Flagged first, then by citations
Cited by
Sorted by citations
The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication
Hudson, J. I., Hiripi, E., Pope, H. G., & Kessler, R. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.040 · Cited by 4,973
Jacobi, C., Hayward, C., de Zwaan, M., KRAEMER, H. C., & Agras, W. S. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.19 · Cited by 1,514
Fairburn, C. G., & Harrison, P. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12378-1 · Cited by 1,396
Risk factors for eating disorders.
Striegel-Moore, R. H., & Bulik, C. M. (2007) · American Psychologist · doi:10.1037/0003-066x.62.3.181 · Cited by 999
Self-citationTreasure, J. L., Claudino, A. M., & Zucker, N. L. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61748-7 · Cited by 661
Metadata
- Authors
- Wade, T. D., Bulik, C. M., Neale, M., & Kendler, K. S.
- Affiliations
- Virginia Commonwealth University (US)
- Venue
- American Journal of Psychiatry
- Published
- 2000-03-01
- Volume
- 157
- Issue
- 3
- Pages
- 469-471
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2134453207
- Cited by
- 375
- References
- 9
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 12 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 6 · 2019: 13 · 2018: 14 · 2017: 11 · 2016: 20 · 2015: 24 · 2014: 16 · 2013: 14 · 2012: 14
- FWCI
- 17.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA009095, AA-09095)
- National Institute of Mental Health (R01MH040828, MH 40828, MH-42953)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- anorexia nervosa, major depressive disorder, comorbidities, heritability, genetic risk factors, shared environment, twin studies, female twins, psychiatric genetics
- MeSH terms
- Adult, Anorexia Nervosa, Depressive Disorder, Diseases in Twins, Female, Humans, Models, Genetic, Phenotype, Risk Factors, Twins, Dizygotic, Twins, Monozygotic, Genetic Variation, Comorbidity, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
