Candidate gene studies of bipolar disorder
Open accessAbstract
Genetic factors undoubtedly play an important role in determining vulnerability to bipolar disorder but the task of finding susceptibility genes is not trivial. Candidate gene studies, usually employing the association approach, offer the potential to discover the genes of relatively modest effect size that are expected for a complex genetic disorder. Candidate gene approaches depend crucially on our current understanding of disease pathophysiology, and attention has consequently been focussed on a limited range of neurotransmitter systems implicated by the action of drug treatments. Despite no unequivocal, consistently replicated findings, a number of intriguing results have emerged in the literature, both for bipolar disorder in general and for subtypes such as bipolar affective puerperal psychosis and rapid cycling bipolar illness. Genes of particular current interest include those encoding the serotonin transporter, monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT). As susceptibility genes are found and knowledge of aetiology advanced it is likely that many more candidate genes in novel biological systems will attract attention.
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Direct implications were demonstrated for the monoamine oxidase A, 5-hydroxytryptamine transporter, and catechol-O-methyltransferase genes in BD.
“In this way, direct implications were demonstrated for the monoamine oxidase A, 5-hydroxytryptamine transporter, and catechol-O-methyltransferase genes [217–220].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [219]
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- Authors
- Jones, I., & Craddock, N.
- Affiliations
- University of Birmingham (GB)
- Corresponding author
- Craddock, Nick
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 33
- Issue
- 4
- Pages
- 248-256
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2129061795
- Cited by
- 44
- References
- 97
- Citations by year
- 2025: 1 · 2022: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- bipolar disorder, candidate gene association, genetic susceptibility, rapid cycling bipolar disorder, serotonin transporter, monoamine oxidase A, catechol-O-methyltransferase, neurotransmitter systems, complex genetic disorders
- MeSH terms
- Bipolar Disorder, Carrier Proteins, Catechol O-Methyltransferase, Genetic Techniques, Genetics, Population, Humans, Membrane Glycoproteins, Monoamine Oxidase, Nerve Tissue Proteins, Receptors, Serotonin, Tyrosine 3-Monooxygenase, Case-Control Studies, Receptors, Dopamine D2, Genetic Predisposition to Disease, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Receptors, Dopamine D3
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